DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and Cad96Ca

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster

Alignment Length:	1046	Identity:	226/1046 - (21%)
Similarity:	349/1046 - (33%)	Gaps:	361/1046 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 RSQIVS--RMSLLRTILLIIISIHFKLAHADQVVLLDTTREATLEWTRYPYGPQAQTPGWVEESF 117
            |.|:.|  |.|||.||:::..::         |.|:....||        :...|....:|.|.
  Fly    16 RKQLTSWRRRSLLLTIIVVTATV---------VSLISQEAEA--------HNQNAPPILYVRER- 62

  Fly   118 TDFVKGINWRSYVVCDVAYHNVNNWLWSPFIDR-------GSANRLYIEIQFTIRDCSLFPGNAL 175
                   |||......|          ...|||       |......||.:|::      ||.
  Fly    63 -------NWRISETEKV----------GQIIDRVRAEDPDGDDLIFGIEPRFSL------PGG-- 102

  Fly   176 SCKETFSLLFYEFDAATREPPPWQTD----------------SYRLIARIAAGEGRFNQNSDVDI 224
                       |.||:..|..|:|.|                ....:..|...:|.:...::|.|
  Fly   103 -----------ENDASPPEKIPFQIDRETGVVTLNESLAGRAGQNFLIYITVTDGSYTAKNEVFI 156

  Fly   225 NTEVKSIAVNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGT 289
            |  :.....|..|    :|.|.:..:|:         ..:::....|::.|..:.|     :||
  Fly   157 N--ILGERENSSG----YRPQTSISNVV---------HNISQFLPRFDQLPGVQSI-----RNG- 200

  Fly   290 CVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKSPEVTKCTPCPPN 354
             :.|:.|           |.|            |.|...|......|.|       ....|.|||
  Fly   201 -LPNSRP-----------GGW------------YPPVPQNNIFGPPPFG-------NNYPPPPPN 234

  Fly   355 SNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSE 419
            ....:...      ||....|::         ...||                 .|.:..|.:.:
  Fly   235 IPGVRGEQ------SGEEEQPDE---------EVTPT-----------------TPVRISSTTPK 267

  Fly   420 TNSKIYHSDIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFK 484
            :.:|:                             |.||..|...|.:      ||.:.:......
  Fly   268 SRTKL-----------------------------TPITANNSTRVES------AIPAETTTPSGG 297

  Fly   485 RHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIV------FTTESVLLSTVFNLRILAIT 543
            .|:|.||                 |:.:..:|:|...||      |...:|||:.:...|:.||:
  Fly   298 HHNNSSS-----------------PITIFSLKSGTIPIVVTVGGFFVAIAVLLAYLCRRRLCAIS 345

  Fly   544 NKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKT 608
                                   |...|.:    .|..|..|..::.:...|.:
  Fly   346 -----------------------RTLKKTK----EKEELAKKSNQSQLSSTLTD----------- 372

  Fly   609 NNGFGSYSNMIYAQTLQSVGSV-----YDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQD 668
                .|.::|:..|....|...     ::...|:......:.|||
  Fly   373 ----DSRNSMVMQQWQGPVAFANRYVPWERDQQMGIATSQLSTGV-------------------- 413

  Fly   669 DLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYED-------PN 726
                                .|...::|       .|.:|..|...|.:.|.....       |.
  Fly   414 --------------------TNGGVSSP-------GVPSPGTGEPGSNLGPGCLTGGAGSSGAPE 451

  Fly   727 QAIREFAREIDAN-------YITIEAIIGGGEFGDVCR-------GRLKIPPNFVQDIDVAIKTL 777
            .|   ||.|.:.:       .:....|:|.|.||.|.|       |...|       ..||:|||
  Fly   452 NA---FAGEANCDRWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGI-------TTVAVKTL 506

  Fly   778 KPGSSEKARCDFLTEASIMGQFD-HPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVN----- 836
            |..::|..|.|.|:|..:|...: |.||::|.|..|..:|..:|.||:..|.|.|:||.:
  Fly   507 KESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSRAERH 571

  Fly   837 ----DGKFQTL---QLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIE 894
                .||...|   .|...:..:|.||.||:....:||||||||:|:.....||:||||.:|::.
  Fly   572 YGNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVI 636

  Fly   895 NASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIE 959
            .:........||:|:||.|.|::....|:..||:||:|:::||:::.|..||...|..||::.:.
  Fly   637 TSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVR 701

  Fly   960 KGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDGNHI- 1023
            .||||..|..|...||.:|..||......||.||.|:..||.|.......:.....|:.:..:|
  Fly   702 DGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKLLHTEMDYIELERFPDHNYYNIV 766

  Fly  1024 -LDGQR 1028
             |.|::
  Fly   767 SLSGEK 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	37/197 (19%)
		FN3	387..476	CDD:238020	12/88 (14%)
		FN3	536..623	CDD:238020	11/86 (13%)
		EphA2_TM	644..736	CDD:291255	14/98 (14%)
		PTKc_EphR	736..1002	CDD:270629	100/292 (34%)
		Pkinase_Tyr	741..999	CDD:285015	98/277 (35%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	23/129 (18%)
		STYKc	470..741	CDD:214568	98/277 (35%)
		PTKc	474..742	CDD:270623	98/274 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455339
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940