Protein Alignment Eph and MET

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: XP_011514525.1
• Gene: MET / 4233
• HGNCID: 7029
• Length: 1409
• Species: Homo sapiens
• Alignment Length: 985
• Identity: 237/985 - (24%)
• Similarity: 365/985 - (37%)
• Gaps: 290/985 - (29%)

  Fly   206 IARIAAGEGRFNQNSDVDINTEVKSIAVNKKG-----VYFAFRDQGACISVLAVKVYYITCPAVT 265
            ||.:...||||.|            :.|::.|     |.|..........|:...         |
Human   471 IANLGTSEGRFMQ------------VVVSRSGPSTPHVNFLLDSHPVSPEVIVEH---------T 514

  Fly   266 ENFAHFNETPTGREITIIE---------------------KQNGTCVDNAEPYETPTYLCKGDGK 309
            .|...:....||::||.|.                     .|.|.|.|.....|.    |. .|.
Human   515 LNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEE----CL-SGT 574

  Fly   310 WT----------------ILTGG-----CRCKAGYEPN-----------YTNKTCT----ECPLG 338
            ||                .|.||     |....|:..|           ..|::||    |..:.
Human   575 WTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMN 639

  Fly   339 TFKSPEVTKCTPCP------------PNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPT 391
            |.      |||..|            .|.:.:...|.|.      |..|......|.|.|.|..|
Human   640 TL------KCTVGPAMNKHFNMSIIISNGHGTTQYSTFS------YVDPVITSISPKYGPMAGGT 692

  Fly   392 NLTL--------------------LFVDQTSAIISWSAPA-----------KNESFSSETNSKIY 425
            .|||                    .....:::|:....||           |.:..:.||:...|
Human   693 LLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSY 757

  Fly   426 HSD-IVYKIKCNICSPNVVYNPSTDTFNETKITLT----NLEPVTTYTVQIHAINSVSHINEFKR 485
            ..| |||:|           :| |.:|.....|:|    ||..|:...:.|:...:..:.....:
Human   758 REDPIVYEI-----------HP-TKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQ 810

  Fly   486 HSNESSLVAVSDIVFSNTSLLNIPLD------LNEVKTGQAEIVFT-------TESVLLSTVFNL 537
            |.:.|.::..:.......: |.:||.      |:.:.:...::::.       .|..::.::.|.
Human   811 HRSNSEIICCTTPSLQQLN-LQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNE 874

  Fly   538 RILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGF 602
            .:|.|...|.|.|..|.          ||       |...|||..|     .|:        :..
Human   875 NVLEIKGNDIDPEAVKG----------EV-------LKVGNKSCEN-----IHL--------HSE 909

  Fly   603 QVRCKTNNGFGSYSNMIYAQTLQSVGS-------VYDDSVQIRFIAG--AIVTGVLFLVIFIIAT 658
            .|.|...|.....::.:..:..|::.|       |..|......|||  :|.|.:|.|:.|.:
Human   910 AVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFL-- 972

  Fly   659 VYFMRSKHQDDLDKK--------STNHL-------------------------PLPLDYASNEVN 690
             :..:.|...||..:        .|.||                         ..|.|...|...
Human   973 -WLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQ 1036

  Fly   691 S----------MDTTPIVKKLHLNVTTPLFGNS----RSYVDP-------HTYEDPNQAIREFAR 734
            :          .|.:||:.....::::||..|:    .|.::|       |....|:..|..|
Human  1037 NGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHF-- 1099

  Fly   735 EIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQF 799
                     ..:||.|.||.|..|.|.  .|..:.|..|:|:|...:.......||||..||..|
Human  1100 ---------NEVIGRGHFGCVYHGTLL--DNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDF 1153

  Fly   800 DHPNVIYLQGVVTRS--NPVMIITEYMENGSLDTFLRVNDGKFQTLQ-LIVMLRGIASGMSYLSD 861
            .||||:.|.|:..||  :| :::..||::|.|..|:| |:....|:: ||.....:|.||.||:.
Human  1154 SHPNVLSLLGICLRSEGSP-LVVLPYMKHGDLRNFIR-NETHNPTVKDLIGFGLQVAKGMKYLAS 1216

  Fly   862 MNYVHRDLAARNVLVNAQLICKIADFGLSREIENAS--DAYTTRGGKIPVRWTAPEAIAFRKFTS 924
            ..:|||||||||.:::.:...|:|||||:|::.:..  ..:...|.|:||:|.|.|::..:|||:
Human  1217 KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTT 1281

  Fly   925 ASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHR 989
            .|||||:||:|||:|:.|..||.:.:..|:...:.:|.||..|..||:.||::||.||..:...|
Human  1282 KSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMR 1346

  Fly   990 PTFASIVSTL 999
            |:|:.:||.:
Human  1347 PSFSELVSRI 1356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	12/58 (21%)
		FN3	387..476	CDD:238020	26/124 (21%)
		FN3	536..623	CDD:238020	18/86 (21%)
		EphA2_TM	640..738	CDD:464211	29/153 (19%)
		PTKc_EphR	736..1002	CDD:270629	102/269 (38%)
		SAM_1	1029..1092	CDD:425739
MET	XP_011514525.1	Sema_MET	44..535	CDD:200539	19/84 (23%)
		PSI	538..580	CDD:214655	9/46 (20%)
		IPT_plexin_repeat1	582..675	CDD:238585	19/104 (18%)
		IPT_plexin_repeat2	676..759	CDD:238584	16/82 (20%)
		IPT_plexin_repeat3	761..856	CDD:238586	19/107 (18%)
		IPT	857..953	CDD:214657	23/125 (18%)
		PTKc_Met_Ron	1101..1362	CDD:270649	102/260 (39%)