DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eph and htl

DIOPT Version :10

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster


Alignment Length:764 Identity:189/764 - (24%)
Similarity:303/764 - (39%) Gaps:194/764 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   341 KSPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAII 405
            |:|.:|.      |:|.|.|.|          ...:||......:....|.|:        |:..
  Fly    61 KTPAITN------NANQSSTSS----------ADLDDGAADDDDNKADLPVNV--------SSKP 101

  Fly   406 SWSAPAKNESFSSETNSKIYHSDIVYKIKCNIC---SPNVVY--NPSTD--------TFNETKIT 457
            .|..|.|.....:..:..:      ..:.|:..   .||:.:  |.:.|        ..|...:|
  Fly   102 YWRNPKKMSFLQTRPSGSL------LTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLT 160

  Fly   458 LTNLEP--VTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEV--KTG 518
            :.:|.|  ...||.::  .||:..|    ||..:   |.|||.|.....|:..||:|..|  .||
  Fly   161 MEDLVPGDCGNYTCKV--CNSLGCI----RHDTQ---VIVSDRVNHKPILMTGPLNLTLVVNSTG 216

  Fly   519 QAEIVFTTESVL-----------LSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVR----- 567
            .....:.::...           ::...|.|.:...:||             .|:|..||     
  Fly   217 SMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKD-------------QLDFVNVRMEQEG 268

  Fly   568 WFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSV----- 627
            |:                                   .|..:|..|..::..|.:.::|:     
  Fly   269 WY-----------------------------------TCVESNSLGQSNSTAYLRVVRSLHVLEA 298

  Fly   628 ----GSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRS-KHQDDLDKK-STNH------LPL 680
                ||::..|....|:.|    |::|:.:..:...|.:|. ||:..|.:: .|.|      :..
  Fly   299 GVASGSLHSTSFVYIFVFG----GLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIF 359

  Fly   681 PLDYASNEVNSMDT--TPIVKKLHLNVTTPLFGNSRSYVDP---HTYEDPNQAIREFAREIDANY 740
            ..:...:...||||  .|:|:......|....||     :|   :.||.|..:..|..|    ::
  Fly   360 KPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGN-----EPAPFNEYEFPLDSNWELPR----SH 415

  Fly   741 ITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIM---GQFDHP 802
            :.:.|.:|.|.||.|....       |.:..||:|.:|.|.::......:.|..:|   |:  |.
  Fly   416 LVLGATLGEGAFGRVVMAE-------VNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGR--HI 471

  Fly   803 NVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVND--GKFQ-----------------TLQLIVM 848
            |:|.|.|..:::.|:.:|.||..:|:|..||..|.  |:.|                 ...||..
  Fly   472 NIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKF 536

  Fly   849 LRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTA 913
            ...||.||.||:....:|||||||||||:...:.|||||||:|:|::.........|::|::|.|
  Fly   537 AHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMA 601

  Fly   914 PEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWN-WSNQDVIKSIEKGYRLPAPMDCPEALYQL 977
            ||::..:.:.|.|||||||::|||:|:||::||.. .|.:::...:..|.|:..|..|...:|.|
  Fly   602 PESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYIL 666

  Fly   978 MLDCWQKQRTHRPTFASIVSTLDNLARQPQSL-------LTTRPSPESD 1019
            |..||......||.|..||..:|.|.:..:..       |.|.||...:
  Fly   667 MRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTPPSTSDE 715

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439
FN3 387..476 CDD:238020 17/103 (17%)
FN3 536..623 CDD:238020 13/91 (14%)
EphA2_TM 640..738 CDD:464211 25/110 (23%)
PTKc_EphR 736..1002 CDD:270629 97/288 (34%)
SAM_1 1029..1092 CDD:425739
htlNP_524394.2 Ig 101..191 CDD:472250 20/104 (19%)
Ig strand B 121..125 CDD:409353 0/3 (0%)
Ig strand C 134..138 CDD:409353 1/3 (33%)
Ig strand E 157..161 CDD:409353 0/3 (0%)
Ig strand F 171..176 CDD:409353 2/4 (50%)
Ig strand G 184..187 CDD:409353 2/2 (100%)
Ig 200..289 CDD:472250 20/136 (15%)
Ig strand B 216..220 CDD:409353 1/3 (33%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 2/16 (13%)
Ig strand F 269..274 CDD:409353 2/39 (5%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 100/300 (33%)
Blue background indicates that the domain is not in the aligned region.

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