DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and Sdr

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001287331.1	Gene:	Sdr / 41809	FlyBaseID:	FBgn0038279	Length:	868	Species:	Drosophila melanogaster

Alignment Length:	697	Identity:	129/697 - (18%)
Similarity:	217/697 - (31%)	Gaps:	234/697 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DKKVKYDGIKSKTSSVTILTSVLNDAISALKSAFYKNQAPISEQNRSQIVSRMSLLRTILLIIIS 74
            |.:|..|.:....|....||::....:.||::|.    |.:.|                    |:
  Fly   341 DLEVLQDCVTINGSLTIELTNIKEKIVDALENAL----ASVKE--------------------IT 381

  Fly    75 IHFKLAHADQVVLLDTTREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCDVAYHNV 139
            .:.|:.|:.|::.|                           :|...:..|.....|....|.:.|
  Fly   382 GYLKVIHSAQLMSL---------------------------TFLQNLDAIRGDKLVENKYALYVV 419

  Fly   140 NNW----LWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAATREPPPWQT 200
            ||:    :|.|       |.|.| ||   |....|..|...|.|..
  Fly   420 NNYHLEHIWPP-------NHLVI-IQ---RGTLFFHLNPRLCYEKI------------------- 454

  Fly   201 DSYRLIARIAAGEGRFNQNSDVDINTEVKSIAVNKKGVYFAFRDQGACISVLAVKVYYITCPAV- 264
              ::|...:.:||           |..|..::.|..|.....   |..:..|..||..:...||
  Fly   455 --HQLQGSLKSGE-----------NISVADVSPNSNGERVIC---GDAVRSLNPKVEDLNSTAVR 503

  Fly   265 ----------TENFA----HFNETPTGREITIIEKQNGTCVDN----AEPYETPTYLCKGDGKWT 311
                      .|...    |:.|.|. :.:|:.:.::|...||    ..|.::..::..|...:|
  Fly   504 IILDYMDWEGMETLIGYSYHYKEAPV-QNVTMYDGRHGCGHDNWLMDVVPNQSRRHVISGLKPYT 567

  Fly   312 ILTGGCRCKAGYEPNYTNKTCTE----------CPLGTFKSPEVTKCTPCPPNSNASKTGSPFCK 366
                        :..|..||.|.          ..:|.|::      .|..|:......||  .:
  Fly   568 ------------QYAYFVKTLTRTEYHIQIDAYSKIGYFQT------LPDRPSPVLRIYGS--SE 612

  Fly   367 CASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIY---HSD 428
            .:|....|         :.||..|..:          |.::...|:..:.:.|...|.|   ..:
  Fly   613 ISSQILLH---------WWPPRRPNGV----------IKNYFVTAEKYNATKEAKDKNYVNVELE 658

  Fly   429 IVYKIKCNICSPNVVY--NPSTDT---FNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSN 488
            ....|.|. |:..:.|  .|..|.   :|:.:||..:..|...|         ||..::::|...
  Fly   659 NAKDIDCE-CAGVLPYYSGPQPDDEDYYNKEQITYEDALPNLIY---------VSRNHDYRRKEF 713

  Fly   489 ESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDK 553
            |.        |.:...||:|..|....:...     ||.:...:|:...|:.||..::..|..:|
  Fly   714 EK--------VINYEHLLSIKKDEEPTRPPT-----TTPAPTNATLAKERLAAINYENYRLNSEK 765

  Fly   554 PVQ--SDFPLEFYEVRW-FPK-----------VELDAINKSALNTKETKA----HIVGLLE-NTE 599
            ..:  .|.....|.:|. .||           ||...:.:..|:..|...    :.:..|| .|.
  Fly   766 KQRDLQDLDQHKYTIRHALPKCQNSHASVVQQVEEKCVAEEPLSGYELPGTQHFYCLSQLEPETH 830

  Fly   600 YGFQVRCKTN---NGFGSYSNMIYAQTLQSVGSVYDDSVQI-RFIAG 642
            |...:|....   ||..:.:..:          :...|:|: |||.|
  Fly   831 YRITIRACVEGVVNGCSTPAEAV----------IKTASIQLERFIKG 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	31/178 (17%)
		FN3	387..476	CDD:238020	18/96 (19%)
		FN3	536..623	CDD:238020	21/108 (19%)
		EphA2_TM	644..736	CDD:291255
		PTKc_EphR	736..1002	CDD:270629
		Pkinase_Tyr	741..999	CDD:285015
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
Sdr	NP_001287331.1	Recep_L_domain	58..173	CDD:279382
		Furin-like	209..332	CDD:279142
		Recep_L_domain	347..461	CDD:279382	34/196 (17%)
		FN3	491..578	CDD:214495	18/99 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455338
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840