Protein Alignment Eph and Csk

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Alignment Length: 1144
• Identity: 245/1144 - (21%)
• Similarity: 389/1144 - (34%)
• Gaps: 390/1144 - (34%)

  Fly    17 GIKSKTSSVTILTSVLNDAISALKSAFYKNQAPISEQNRSQIVSRMSLLRTILLIIISIHFKLAH 81
            |:....||||                 :|..:..:.....|::||......:|...:|..:....
  Fly   122 GLTRSASSVT-----------------HKEASTHATHTGGQVISRARRKPILLCSSLSAAYAPPR 169

  Fly    82 ADQVVLLDTTREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCDVAYHNVNNWLWSP 146
            ..:....|          :|..||...||.....|.|.               |.|..     ||
  Fly   170 RREFYFCD----------KYAPGPARSTPTTTTTSATS---------------AKHES-----SP 204

  Fly   147 FID------------RGSANRLYIEIQFTIRDCSLFPGN-----ALSCKETFSLL--------FY 186
            .||            :..|::...|:|.| :|  .|.||     :.:.::|...|        ::
  Fly   205 PIDARLLNFLRCAHRKFQASKAKTELQQT-KD--RFLGNSRERTSKNGQQTSRSLPPIASSEEWF 266

  Fly   187 EFDAATR--------EPPPWQTDSYR---LIARIAAGEGRFNQNSDVDINTEVKSIAVNKKGVYF 240
            :.:|..|        :|.|...::::   .|:|.|:|||..       |..|:|...:.|:
  Fly   267 DEEAQARKTSHEKSQKPKPKPEENHKEKEAISRKASGEGDL-------ITVEIKQGLLRKQ---- 320

  Fly   241 AFRDQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCK 305
                               |....|....:.:.|.|         |||.
  Fly   321 -------------------TATTTTGQAMNSHATAT---------QNGQ---------------- 341

  Fly   306 GDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKSPEVTKCTPCPPNSNASKTGSPFCKCASG 370
                 |.:.|..|                    .|..|.||........|.|   |.|:....:|
  Fly   342 -----TTVVGHHR--------------------GFSQPSVTVAAAAATGSTA---GDPWFLQTTG 378

  Fly   371 FYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAII----SWSAPAKNESFSSETNSKIYHSDIVY 431
                     |.   .||.||.........|.:|::    |.:||      .|...:.:.|...:.
  Fly   379 ---------HQ---MPPTAPLRHNKRPAPQPNAVLGAGSSGTAP------GSAVGAVLLHQQQLS 425

  Fly   432 KIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNES------ 490
            :.:.:|..|::  .|......|..:............:..||:||.:.|:....||.:|
  Fly   426 QSQPHIVPPSI--PPHHHHHRENNVHPIQAGAAAALHLSSHALNSHNLISSASNHSPKSPSQTQQ 488

  Fly   491 -------------------------------------------SLVAVSDIVFSNTS-----LLN 507
                                                       :..||:.:......     |.|
  Fly   489 QQQTTNQQQQQQQQQASHSILSTFAPAPTVAAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQLLAN 553

  Fly   508 IP--------LDLNEVKTGQ--AEIVFTTESVLLS-TVFNLRILAITNKDADLEWDKPVQSDFPL 561
            .|        ..||..:.|.  ||.....:|:.|| :.....:|..|.       .:|.|:..|
  Fly   554 CPPGGAGLMSSSLNAAQMGMHGAERALPPKSLALSGSQHGSNMLLHTA-------PQPPQASQP- 610

  Fly   562 EFYEVRWFPKVELDAINKSALNTKETKAHIVGL-------LENTEYGFQVRCKTNNGFGSYSNMI 619
                                       |.:||:       :..:.:.|.:     ||..:.|.:.
  Fly   611 ---------------------------AAVVGVSGSGSAGMSTSLHSFDI-----NGVTAGSGVN 643

  Fly   620 YAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDD-------------LD 671
            .:....|..:...:...:...|.|...|.....:.:.|..:|..|..:|:             |.
  Fly   644 ASSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLV 708

  Fly   672 KKSTNHLPLPLDYA-----SNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIRE 731
            ::|||   .|.||.     .::|.......:..||.::             |...:|:..|.:..
  Fly   709 RESTN---FPGDYTLCVCFQSKVEHYRVKYLENKLTID-------------DEEYFENLGQLVAH 757

  Fly   732 FARE---------------------------IDANYITIEA------IIGGGEFGDVCRGRLKIP 763
            :..:                           :|..::..||      .||.||||||..|.|:
  Fly   758 YEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILR-- 820

  Fly   764 PNFVQDIDVAIKTLK-PGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENG 827
                 :..||:|.|| .|:.:|    ||.|||:|...:|.|::...|:|..|..:.::||||..|
  Fly   821 -----NEKVAVKMLKDEGAVQK----FLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKG 876

  Fly   828 SLDTFLRVNDGKFQTLQ-LIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSR 891
            ||..:||....:..|.: .|:.....||||.||.....|||||||||||::...:.|::||||:|
  Fly   877 SLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR 941

  Fly   892 EIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIK 956
            |     :.|....||:|::||||||:...:|::.||:||:|::|||:.|:|..||......||:|
  Fly   942 E-----ECYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVK 1001

  Fly   957 SIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASI 995
            .:|.||::.||..||..:|::|...|......|||||.:
  Fly  1002 HVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	38/210 (18%)
		FN3	387..476	CDD:238020	16/92 (17%)
		FN3	536..623	CDD:238020	12/93 (13%)
		EphA2_TM	640..738	CDD:464211	20/142 (14%)
		PTKc_EphR	736..1002	CDD:270629	107/268 (40%)
		SAM_1	1029..1092	CDD:425739
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	17/112 (15%)
		PTKc_Csk_like	793..1047	CDD:270635	106/264 (40%)