Protein Alignment Eph and FER

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Alignment Length: 1071
• Identity: 243/1071 - (22%)
• Similarity: 375/1071 - (35%)
• Gaps: 367/1071 - (34%)

  Fly   173 NALSCKETFSLLFYEF------DAATREPPPWQTDSYRLIARIAAGEGRFNQNSDVDINTEVKSI 231
            |||.|:|.......:.      :....|.|....|...|.....  |..:|.......:|....:
  Fly   373 NALRCQEKQKQKLVDMIKCALNEVGCEELPSGCDDDLTLEQNFI--ENGYNNEQQRSNSTSSPGL 435

  Fly   232 AV-----NKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCV 291
            .:     .:.||....|.:|                      .||....|.:..|.:.:......
  Fly   436 GIMNELMRRGGVLTLLRGRG----------------------RHFKRKSTPQPATPMTRSRQGRF 478

  Fly   292 DNAEPYETPTYLCKGDGKWTIL-TGGCRCKAGYEPNYTNKTCTECPLGTFKSPEVTKCTPCPPN- 354
            :..:|..      :..|..::: .|.....|.||| .||....:.....:...|:...:..||:
  Fly   479 NKLQPRS------QSLGSLSVIRDGNGPSPARYEP-ITNHRLRQAASVHYLGEEIATSSTNPPDL 536

  Fly   355 SNASKTGSPFCKCASGFYRHPNDGRHMPCYSPP------AAPTNLTLLFVDQTSAIISWSAPAKN 413
            :...:|     :|:            |.|....      |:|..||.|    |:|::
  Fly   537 TRLRRT-----QCS------------MLCLGEDEEPVVLASPAPLTQL----TAAVL-------- 572

  Fly   414 ESFSSETNSKIYHSDI------------------------VYKIKCNICSPNVVYNPSTDTFNET 454
                :.||:...::|:                        ..:|:.|..:|....:...|..:|.
  Fly   573 ----TNTNNNHIYADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDEL 633

  Fly   455 KITLTN-----LEPVTTYTVQIHAINSV--SHI----------NEFKRHSNESSLVAVS------ 496
            ...|.:     |:|    :..::||.|.  :||          ::.||.|:.||....|
  Fly   634 NRVLDDRLKRTLQP----SDDVNAIESAEENHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSHS 694

  Fly   497 ---DIVFSNTSLLNIPLDLNE------VKTGQAEIV----------------------------- 523
               .:.||..|:.||..:|.|      |:.|:..|:
  Fly   695 KKRSLSFSQKSISNIFSNLKEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSS 759

  Fly   524 -----------------FTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPK 571
                             ..::|.::::.....|...|.       ..|.:.:..|:|.    .||
  Fly   760 SSNNNNNNKNTSSNSNHSASQSTIITSTITTTITTTTT-------TTPSKENSRLKFK----VPK 813

  Fly   572 VELDAINKSALNTKETKAHIVGLLENTEYGFQVR-------C-KTNNGFGSYSNMIYAQTL---Q 625
            ::..  :|:..||..:|     ||     .||::       | |......|.|...:|:..   |
  Fly   814 IQKK--SKAIRNTFRSK-----LL-----NFQLKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQ 866

  Fly   626 SVGSVYDD---------------SVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQD------- 668
            ..||..|:               ||||                          |.|:|
  Fly   867 PAGSAADEQFCNCPPAGQKPVKPSVQI--------------------------SGHKDHPFESSS 905

  Fly   669 -DLDKKSTNHL---PLPLDYASNEVNSMD-----TTPIVKKLHLNVTTPLF-------------- 710
             :||:.|...:   ....|.||::|.||.     ...:...:.|:...||:
  Fly   906 GELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEV 970

  Fly   711 ------------------------------------------GNSRSYVDP---------HTYED 724
                                                      ||.|....|         |.|..
  Fly   971 VRLLNNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHS 1035

  Fly   725 ------PNQAI--REFAR---EIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLK 778
                  .:.||  |...|   |:..:.:.:...||.|.||||.:.:||     ...:|||:||.:
  Fly  1036 ELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLK-----STKLDVAVKTCR 1095

  Fly   779 PGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTL 843
            ....::.:..||.|..|:.|:||||::.|.|:..:..|:||:.|.:..|||.|:||.|.....|.
  Fly  1096 MTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTR 1160

  Fly   844 QLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGG--K 906
            |.:.|.|..|:||.||...|.:||||||||.||:.:...||:|||:|||.|.    |....|  :
  Fly  1161 QQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEE----YIVSDGMKQ 1221

  Fly   907 IPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCP 971
            |||:||||||:.|.|:||..||||||:::||:.|.|:.||...:|....:.|:.|||:|.|...|
  Fly  1222 IPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTP 1286

  Fly   972 EALYQLMLDCWQKQRTHRPTFASIVSTLDNL 1002
            |.:|:|||.||......||.|..|.:.:|.|
  Fly  1287 EEMYRLMLQCWAADAESRPHFDEIYNVVDAL 1317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	16/97 (16%)
		FN3	387..476	CDD:238020	20/123 (16%)
		FN3	536..623	CDD:238020	20/94 (21%)
		EphA2_TM	640..738	CDD:464211	26/189 (14%)
		PTKc_EphR	736..1002	CDD:270629	112/267 (42%)
		SAM_1	1029..1092	CDD:425739
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	8/85 (9%)
		PTKc_Fes_like	1067..1315	CDD:270637	111/256 (43%)