DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eph and LTK

DIOPT Version :10

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:NP_002335.2 Gene:LTK / 4058 HGNCID:6721 Length:864 Species:Homo sapiens


Alignment Length:407 Identity:130/407 - (31%)
Similarity:202/407 - (49%) Gaps:59/407 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   647 GVLFLVIFIIAT-----------VYFMRSKHQDDLDKKSTNHLPLP-LDYASNEVNSMDTTPIVK 699
            |.|.|::.::||           :..::.|....|.:.   .||.| |:.:....:::.|.|   
Human   423 GPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEM---RLPSPELELSKLRTSAIRTAP--- 481

  Fly   700 KLHLNVTTPLF-----GNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGR 759
                   .|.:     |.::|:..|     |.      ..|:....:|:...:|.|.||:|..|.
Human   482 -------NPYYCQVGLGPAQSWPLP-----PG------VTEVSPANVTLLRALGHGAFGEVYEGL 528

  Fly   760 LKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYM 824
            :...|.....:.||||||....|.:...|||.||.|:.:|.|.|::...|:..|:.|.:|:.|.|
Human   529 VIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELM 593

  Fly   825 ENGSLDTFLRVND---GKFQTL---QLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNA---QL 880
            ..|.:.:|||.:.   |:...|   .|:.:.:.||.|..||.:.:::|||:||||.|::.   ..
Human   594 SGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSR 658

  Fly   881 ICKIADFGLSREIENASDAYTTRGGK--IPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGE 943
            :.||.|||::|:|..||  |..||.:  :||:|..|||.....|||.:|.||:||:|||:.|.|.
Human   659 VAKIGDFGMARDIYRAS--YYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGY 721

  Fly   944 RPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQP-- 1006
            .||...:||:|:..:..|.|:..|..||..:|::|..|||.:...||:||||:..|....:.|  
Human   722 MPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDV 786

  Fly  1007 -QSLLTTR--PSPESDG 1020
             .|||...  |:||.:|
Human   787 LNSLLPMELGPTPEEEG 803

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439
FN3 387..476 CDD:238020
FN3 536..623 CDD:238020
EphA2_TM 640..738 CDD:464211 19/107 (18%)
PTKc_EphR 736..1002 CDD:270629 103/276 (37%)
SAM_1 1029..1092 CDD:425739
LTKNP_002335.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 30..64
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 239..297
PTKc_ALK_LTK 503..779 CDD:270632 104/277 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 790..830 6/14 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 842..864
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.