DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eph and Tie

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster


Alignment Length:938 Identity:192/938 - (20%)
Similarity:337/938 - (35%) Gaps:257/938 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   271 FNETPTGREITIIEKQNGT---CVDNAEPY----------------------ETPTYLCKGDGKW 310
            |::..:.....:.::||||   ..|..:|.                      |...|:..|....
  Fly   287 FSDESSHGLFVVAKEQNGTLNHIADGTKPAVMGKGIPSKTNSMEDDVEEEEDELKPYVYFGAKLP 351

  Fly   311 TILTGGCRCKAGYEPNYTNKTCTECPLGTFKSPEV--TKCTPCP-----PNSNASKTGSPFCKCA 368
            .|..||...||. |.:..:....|..:....:|.:  |..||.|     |.::..:..:|..:..
  Fly   352 PIRPGGLTIKAA-EGDDDHPRVLEVSVAQSTTPTITTTSTTPAPVSSTRPTASTRRPLTPVERSR 415

  Fly   369 SGFYRHPNDGRHMPCYS-PPAAPTNLTLLFVDQTSAIISWSAPAKNESFS----SETNSKIYH-- 426
            |.:..|..:...:|..: |||||....   |.:|..:.| ..|....|.|    .:|.|::..  
  Fly   416 SKYKYHMRERGLVPTAAPPPAAPPAPP---VSRTRYVGS-GRPTAGLSDSIQDLKQTESEVAKPV 476

  Fly   427 -SDIVYKIKCNICSPNVV---------------YNPSTDTFNETKITLTNLEPVTTYTVQIHAIN 475
             ..:|.|:..:..:|.::               ..|:.::...|..|.|..:|.||.:.......
  Fly   477 VRRVVQKVSPSSSTPLIITVLSAEEETTVGQTEALPTDESTTTTSTTTTTEKPSTTTSTSTTTTT 541

  Fly   476 SVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRIL 540
            .|...:  ||.:..:.|           |..|.|.......|.......:|.:.::.|  ..:..
  Fly   542 PVPSTS--KRTTTNAPL-----------STTNTPTTTTSSTTPSTTTTSSTSTTVIPT--TTKAN 591

  Fly   541 AITNKDADLEWDKPVQSDFPLEFYEVR------------------WFPKVELDAINKSALNTKET 587
            :|..||.:|     :::..|....|:.                  ..|:.:....:.:..:.|..
  Fly   592 SIIEKDKEL-----IRALGPALTREINIDDANNLIVFCNNTSDCGVTPRTQTQPSHTTDSSPKIL 651

  Fly   588 KAHIVGLLENTEYGFQVRCKTNN--------GFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGA- 643
            :..::..:.:|.:.......|..        ...:.||.:|...::|..|.....:....||.. 
  Fly   652 RTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSNEVYIGIVESSSSASPADISSTVIANER 716

  Fly   644 ----------IVTGVLF---------LVIFIIATVYFMR-------------------------S 664
                      :||.||.         ::::::......|                         |
  Fly   717 DLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDS 781

  Fly   665 KHQ-----DDLDKKSTNHLPLPLDYASNEVNSMD-----TTPIVKKLHLNVTTPLFGNSRSYVDP 719
            |:|     |::|.:...|    :.:..|..|..:     ..|:.:....:.....:||:      
  Fly   782 KYQVDDDEDEVDHQHHQH----MQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNN------ 836

  Fly   720 HTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRL-KIPPNFVQDIDVAIKTLKPGSSE 783
               :|......|| .:.:.:.|.:::::|.|.||.|.:... .:..:|.....||:||::..|::
  Fly   837 ---DDKTSLASEF-HDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQ 897

  Fly   784 KARCDFLTEASIMGQF-DHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIV 847
            .:..|   ||:||.:. .|.||:.|.|....|.|.|:|.||...|.|.:.||........|...|
  Fly   898 VSLKD---EANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASV 959

  Fly   848 ------------MLRG----IASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIE-- 894
                        .|.|    ||.||.|::....|||||||||||::...:|||.|||:|.:::  
  Fly   960 PGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAE 1024

  Fly   895 --------NASD-------------------------------------------------AYTT 902
                    ||::                                                 .:.|
  Fly  1025 RMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDT 1089

  Fly   903 RGGK--IPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLP 965
            .|.:  :|:||.|||::.:..||:.:|:|::|:||||:.:.|..||...:.::||:.:.:|.|..
  Fly  1090 IGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPD 1154

  Fly   966 APMDCPEALYQLMLDCWQKQRTHRPTFA 993
            .|.:.....|.||..||.|:...||:||
  Fly  1155 LPKESRHEFYNLMSRCWHKEPHMRPSFA 1182

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439
FN3 387..476 CDD:238020 22/110 (20%)
FN3 536..623 CDD:238020 13/112 (12%)
EphA2_TM 644..736 CDD:291255 19/135 (14%)
PTKc_EphR 736..1002 CDD:270629 96/337 (28%)
Pkinase_Tyr 741..999 CDD:285015 96/332 (29%)
SAM_1 1033..1092 CDD:278937
SAM 1039..1092 CDD:197735
TieNP_523928.1 TyrKc 854..1183 CDD:197581 96/332 (29%)
PTKc 860..1187 CDD:270623 95/326 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45455319
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.940

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