DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and AT1G10850

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001077512.4	Gene:	AT1G10850 / 3766694	AraportID:	AT1G10850	Length:	663	Species:	Arabidopsis thaliana

Alignment Length:	744	Identity:	142/744 - (19%)
Similarity:	250/744 - (33%)	Gaps:	235/744 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   401 TSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTFN-----------ET 454
            :|:.:|:...|....|...|.::....:.:..:|.:|...|.:....||..|           .:
plant     9 SSSTVSFVVFAFTVFFCLVTPARSSDVEALLSLKSSIDPSNSISWRGTDLCNWQGVRECMNGRVS 73

  Fly   455 KITLTNLEPVTTYTVQIHAINSVSHIN--EFKRHSNESSLVAVSDIVFSNTSLLN---------- 507
            |:.|..|.  .|.::...::|.:..:.  .||.:|...|:..:|.:|...:..||
plant    74 KLVLEYLN--LTGSLNEKSLNQLDQLRVLSFKANSLSGSIPNLSGLVNLKSVYLNDNNFSGDFPE 136

  Fly   508 ---------------------IP---LDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDAD 548
                                 ||   |.|:.:.|...|....|.|:......:||...::|
plant   137 SLTSLHRLKTIFLSGNRLSGRIPSSLLRLSRLYTLNVEDNLFTGSIPPLNQTSLRYFNVSN---- 197

  Fly   549 LEWDKPVQSDFPL-----EFYEVRWFPKVEL--DAINK--------SALNT-----KETKAHIVG 593
                ..:....||     :|.|..:...|.|  |.|..        ||..|     |::||.::|
plant   198 ----NKLSGQIPLTRALKQFDESSFTGNVALCGDQIGSPCGISPAPSAKPTPIPKSKKSKAKLIG 258

  Fly   594 LLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIAT 658
            :                                             |||::..|||.|::.:...
plant   259 I---------------------------------------------IAGSVAGGVLVLILLLTLL 278

  Fly   659 VYFMRSKHQD-------------------------DLDKKSTNHLPLPLDYASNEVNSMDTTPIV 698
            :...|.|.::                         |:::|...     ..:...|..::.|...:
plant   279 IVCWRRKRRNQAPREDRKGKGIAEAEGATTAETERDIERKDRG-----FSWERGEEGAVGTLVFL 338

  Fly   699 KKLHLNVTTPLFGNSRS--YVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLK 761
                        |.|.|  .|..:|.||..:|..|              .:|.|..|...:..::
plant   339 ------------GTSDSGETVVRYTMEDLLKASAE--------------TLGRGTLGSTYKAVME 377

  Fly   762 IPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMEN 826
              ..|:    |.:|.||.....:.. :|.....|:||..|||::.|:.........:::.:|..|
plant   378 --SGFI----VTVKRLKNARYPRME-EFKRHVEILGQLKHPNLVPLRAYFQAKEERLLVYDYFPN 435

  Fly   827 GSLDTFLR----VNDGK-FQTLQLIVMLRGIASGMSYL-SDMNYVHRDLAARNVLVNAQLICKIA 885
            |||.|.:.    ...|| ......:.:...:||.:.|: .:....|.:|.:.|||:.......:.
plant   436 GSLFTLIHGTRASGSGKPLHWTSCLKIAEDLASALLYIHQNPGLTHGNLKSSNVLLGPDFESCLT 500

  Fly   886 DFGLSR-----EIENASDAYTTRGGKIPVRWTAPEAIAFRK-FTSASDVWSYGVVLWEVMSYGER 944
            |:|||.     .:|..|        .:.:.:.|||....|| .|..:||:|:||:|.|::: |..
plant   501 DYGLSTLHDPDSVEETS--------AVSLFYKAPECRDPRKASTQPADVYSFGVLLLELLT-GRT 556

  Fly   945 PYWNWSNQDVIK----SIEKGYRL-----------------PAPMDCPEALYQLMLDCWQKQRTH 988
            |:     ||:::    .|.:..|.                 .|..:..:||..:...|...|..:
plant   557 PF-----QDLVQEYGSDISRWVRAVREEETESGEEPTSSGNEASEEKLQALLSIATVCVTIQPDN 616

  Fly   989 RPTFASIVSTL-DNLARQPQSLLTTRPSP 1016
            ||....::..: |..|..|.|..::..||
plant   617 RPVMREVLKMVRDARAEAPFSSNSSEHSP 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	15/85 (18%)
		FN3	536..623	CDD:238020	18/106 (17%)
		EphA2_TM	644..736	CDD:291255	19/118 (16%)
		PTKc_EphR	736..1002	CDD:270629	65/299 (22%)
		Pkinase_Tyr	741..999	CDD:285015	64/290 (22%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
AT1G10850	NP_001077512.4	LRRNT_2	32..67	CDD:369783	6/34 (18%)
		PLN00113	<81..641	CDD:215061	126/666 (19%)
		leucine-rich repeat	97..119	CDD:275380	5/21 (24%)
		leucine-rich repeat	120..143	CDD:275380	2/22 (9%)
		leucine-rich repeat	144..167	CDD:275380	4/22 (18%)
		leucine-rich repeat	168..189	CDD:275380	4/20 (20%)
		PKc_like	363..627	CDD:389743	64/284 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050