Protein Alignment Eph and Fak

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: NP_001137718.1
• Gene: Fak / 37233
• FlyBaseID: FBgn0020440
• Length: 1500
• Species: Drosophila melanogaster
• Alignment Length: 978
• Identity: 226/978 - (23%)
• Similarity: 355/978 - (36%)
• Gaps: 290/978 - (29%)

  Fly   191 ATREPPPWQTD---------------SYRLIARIAAGEGRFNQNSDV---------DINTEVKSI 231
            ||.:|||.:.:               |::.:        |||....|         |:.|:.::.
  Fly     6 ATSQPPPTKNEINSEEYLIHVHMPNKSFKAV--------RFNVKETVFHVIRRTVEDLGTDGRTP 62

  Fly   232 AVNK----------KGVYFAFRD---QGACISVLAVKVYYITCPAVTENFAHFNET--PTGREIT 281
            ::.:          |.|.:..|.   |.....:|......:.||   .|.:..:|.  ..||.||
  Fly    63 SIQRYACRMLNMITKEVIWLARSTSMQKVLSHILTPGCSNVDCP---NNQSELDEVLLEHGRRIT 124

  Fly   282 IIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKSPEVT 346
                      ||.              .|.:     ..:..|.||...:...|.....|......
  Fly   125 ----------DNR--------------VWRV-----ELRVRYVPNNIQELFEEDKATCFYYFNQV 160

  Fly   347 KCTPCPPNSNASKTGSPFCKCASGFYRH---------PNDGRHMPCYSPPAAPTNLTLLFVDQTS 402
            |......|..|..|......|..|. ||         |:..:|:..........:    |:.|
  Fly   161 KEDFIQANVTAIDTEVAVQLCCLGI-RHYFKNITVKAPDKKQHIDYIEKEIGFKS----FLPQ-- 218

  Fly   403 AIISWSAPAKNESFSSETNSKIY-HSDIVYKIKCNICSPNVVYNPSTDTFNETK-ITLTNLEPVT 465
            ::|:.|.|...:........|:| ::||.|               .|..|:..| |.|||.|..:
  Fly   219 SVIATSKPKNLKKLIQVGYKKVYNYNDIEY---------------LTRFFDLLKNIYLTNFEQFS 268

  Fly   466 TYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIP--LDLNEVKTGQAEIVFTTES 528
            ........|:.:.|:...         :.:|.......||.|:.  .|:..:||..
  Fly   269 VTLSSAWNISGILHVGPH---------IGISYQTHPQASLKNVAQFKDVVSIKTCT--------- 315

  Fly   529 VLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVG 593
                                                    .||   :.::||..||.|.:
  Fly   316 ----------------------------------------LPK---EKLSKSGENTTEPE----- 332

  Fly   594 LLENTEYGFQVRC---KTNNGFGSYSN----MIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFL 651
             |:|    |...|   ||.....:.:|    :|....:.:..|:.|           ::.|...|
  Fly   333 -LQN----FNCNCQKIKTQIKISASNNVEDLVITCNGINTAESIAD-----------LIDGYCRL 381

  Fly   652 VIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSY 716
            :...:....:.|..:..:.|  |...||......||:..|....|::...:..:  .|......|
  Fly   382 LSKDLEFTIWHRETNASNED--SAKALPNDATLGSNKSTSSQGKPMLTDDYAEI--GLLEGEGDY 442

  Fly   717 VDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIP------------------ 763
            ..|        .:|.:  |:|...||..|.||.|:||||..|...:|
  Fly   443 STP--------TVRNY--ELDRALITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSD 497

  Fly   764 -------PNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIIT 821
                   |:.:|   |||||.|.....:...:||.||.||.:||||::|.|.|:.: ..|:.|:.
  Fly   498 QRNADSRPDVIQ---VAIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIRLIGICS-VMPIWIVM 558

  Fly   822 EYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIAD 886
            |..:.|.|..:|:.|..:.....|:.....:::.:|||....:||||:|||||||::....|:||
  Fly   559 ELAKLGELRAYLKTNSERLSHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLAD 623

  Fly   887 FGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSN 951
            |||||.:.:.|..::|....:|::|.:||:|.||:||:|||||.:||.:||::..|.:|:....|
  Fly   624 FGLSRWVSDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKN 688

  Fly   952 QDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTL------------DNLAR 1004
            .|||..:|.|.|||.|.:||..||.||..||..:...||.|..|..||            :.|.|
  Fly   689 SDVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEILIEDSINSSETLKR 753

  Fly  1005 QPQSLLT-------------TRPS------------PESDG---NHILDGQRGQNIFISTDLWLE 1041
            :.:.:.:             ::||            ||:.|   .:|:    .||..:...|.:|
  Fly   754 EQRKVASMSWIGSDDIDIPPSKPSRVMHDPDITGLMPETTGLPQTYII----AQNPAVLAKLMME 814

  Fly  1042 HIK 1044
            :.|
  Fly   815 NQK 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	17/105 (16%)
		FN3	387..476	CDD:238020	19/90 (21%)
		FN3	536..623	CDD:238020	15/93 (16%)
		EphA2_TM	640..738	CDD:464211	16/97 (16%)
		PTKc_EphR	736..1002	CDD:270629	110/302 (36%)
		SAM_1	1029..1092	CDD:425739	5/16 (31%)
Fak	NP_001137718.1	B41	24..267	CDD:214604	56/304 (18%)
		FERM_B-lobe	152..257	CDD:271216	23/126 (18%)
		FERM_C_FAK1	263..394	CDD:270011	30/212 (14%)
		PTKc_FAK	450..744	CDD:133187	111/299 (37%)
		Focal_AT	1250..1376	CDD:460992