DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eph and Epha2

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:NP_001102447.1 Gene:Epha2 / 366492 RGDID:1307204 Length:977 Species:Rattus norvegicus


Alignment Length:1069 Identity:407/1069 - (38%)
Similarity:568/1069 - (53%) Gaps:171/1069 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 AHADQVVLLD-TTREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCDVAYHNVNNWL 143
            |...:||||| ...:..|.|..:|||     .||  :...:.:..:....|.||:|...:.:|||
  Rat    23 AQGKEVVLLDFAAMKGELGWLTHPYG-----KGW--DLMQNIMNDMPIYMYSVCNVVSGDQDNWL 80

  Fly   144 WSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDA--ATREPPPWQTDSYRLI 206
            .:.::.|..|.|::||::||:|||:.|||.|.||||||:|.:.|.|.  .|.    :|...:..|
  Rat    81 RTNWVYREEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDVDYGTN----FQKRQFTKI 141

  Fly   207 ARIAAGEGRFNQNSD-----VDINTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCPAVT 265
            ..||..|  ...:||     |.:|.|.:.:. :.:||.|.||:|.|||:::|:|:|||..||.:.
  Rat   142 DTIAPDE--ITVSSDFEARNVKLNVEERMVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPEML 204

  Fly   266 ENFAHFNETPTGREITIIEKQ-----NGTCVDNA-EPY--ETPTYLCKGDGKWTILTGGCRCKAG 322
            ::.|.|.||..   :.:.:.|     .|||||:| .||  |.|...|..||:|.:..|.|.|:.|
  Rat   205 QSLARFPETIA---VAVSDAQPLATVAGTCVDHAVVPYGGEGPLMHCTVDGEWLVPIGQCLCQEG 266

  Fly   323 YEPNYTNKTCTECPLGTFKS-PEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSP 386
            ||.  ....|..|..|.||| ...:.|..||.::..|..|:..|:|..|::|.|.|...|||..|
  Rat   267 YEK--VEDACQACSPGFFKSEASESPCLQCPEHTLPSTEGATSCQCEEGYFRAPEDPLSMPCTRP 329

  Fly   387 PAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSP----------N 441
            |:||..||.:.:. ....:.|:||       .:|..:   .||||.:.|..|.|          :
  Rat   330 PSAPHYLTAIGMG-AKVELRWTAP-------QDTGGR---KDIVYSVTCEQCWPESGECGSCEAS 383

  Fly   442 VVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLL 506
            |.|:........|.:|:::|||...||..:.|.|                  .|||:|.|.:   
  Rat   384 VQYSEPPQALTRTSVTVSDLEPHMNYTFTVEARN------------------GVSDLVNSRS--- 427

  Fly   507 NIPLDLNEVKTGQAEIVFTTESVLLSTVF--NLRILAITNKDADLEWDKPVQSDFPLEFYEVRWF 569
                             |.|.||.::...  .:|:...:.....:.|..||.....:..|||.:.
  Rat   428 -----------------FRTASVSINQTEPPKVRLEDRSTTSLSVAWSIPVPQQSRVWKYEVTYR 475

  Fly   570 PKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDS 634
            .|.:.::.|  ...|......:.||...|.|..||:..|..|.|:.|.:...|||.:.||.    
  Rat   476 KKGDANSYN--VHRTDGFSVTLDGLAPGTTYLVQVQALTQEGQGAGSKVHEFQTLSTEGSA---- 534

  Fly   635 VQIRFIAGAIVTGVLFLVIFIIATVYFM----------RSKHQDDLDKKSTNHLPLPLDYASNEV 689
              ...:.|.:..||:.|:  ::|.:.|.          |...:|....||....||         
  Rat   535 --TMAVIGGVAVGVVLLL--VLAGIGFFIHRRRRNLRARQSSEDVYFSKSEQLKPL--------- 586

  Fly   690 NSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGD 754
                                    ::|||||||||||||:.:|..||..:.::.:.:||.||||:
  Rat   587 ------------------------KTYVDPHTYEDPNQAVLKFTTEIHPSCVSRQKVIGAGEFGE 627

  Fly   755 VCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMI 819
            |.:|.|| ..:..::|.|||||||.|.:||.|.|||:||||||||.|.|:|.|:|||::..|:||
  Rat   628 VYKGTLK-SSSGKKEIPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHNIIRLEGVVSKYKPMMI 691

  Fly   820 ITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKI 884
            ||||||||:||.|||..||:|..|||:.|||||||||.||::||||||||||||:|||:.|:||:
  Rat   692 ITEYMENGALDKFLREKDGEFSVLQLVGMLRGIASGMKYLANMNYVHRDLAARNILVNSNLVCKV 756

  Fly   885 ADFGLSREIENASDA-YTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWN 948
            :||||||.:|:..:| |||.|||||:||||||||::|||||||||||||:|:||||:|||||||.
  Rat   757 SDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSYGIVMWEVMTYGERPYWE 821

  Fly   949 WSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLT-- 1011
            .||.:|:|:|..|:|||.|||||.|:||||:.|||::|:.||.||.|||.||.|.|.|.||.|  
  Rat   822 LSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERSRRPKFADIVSILDKLIRAPDSLKTLA 886

  Fly  1012 ---TRPS---PESDGNHILDGQRGQNIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQ 1070
               .|.|   |.:.|:..:.       |.:...|||.|||.:|..||..|.....:::.:::...
  Rat   887 DFDPRVSIRLPSTSGSEGVP-------FRTVSEWLESIKMQQYTEHFMVAGYTAIEKVVQMSNDD 944

  Fly  1071 LSDMGITLVGHQKKILHQ----ARQLDTI 1095
            :..:|:.|.||||:|.:.    ..|::|:
  Rat   945 IKRIGVRLPGHQKRIAYSLLGLKDQVNTV 973

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 67/183 (37%)
FN3 387..476 CDD:238020 26/98 (27%)
FN3 536..623 CDD:238020 20/86 (23%)
EphA2_TM 644..736 CDD:291255 25/101 (25%)
PTKc_EphR 736..1002 CDD:270629 173/266 (65%)
Pkinase_Tyr 741..999 CDD:285015 170/258 (66%)
SAM_1 1033..1092 CDD:278937 18/62 (29%)
SAM 1039..1092 CDD:197735 17/56 (30%)
Epha2NP_001102447.1 EphR_LBD_A2 27..200 CDD:198448 67/185 (36%)
fn3 331..421 CDD:278470 27/118 (23%)
FN3 440..527 CDD:238020 20/88 (23%)
EphA2_TM <576..609 CDD:291255 18/65 (28%)
PKc_like 608..876 CDD:304357 174/268 (65%)
Pkinase_Tyr 614..872 CDD:285015 170/258 (66%)
SAM_EPH-A2 903..972 CDD:188942 19/75 (25%)
SAM 903..969 CDD:197735 18/72 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 399 1.000 Domainoid score I718
eggNOG 1 0.900 - - E2759_KOG0196
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 763 1.000 Inparanoid score I521
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D397694at33208
OrthoFinder 1 1.000 - - FOG0000086
OrthoInspector 1 1.000 - - otm46382
orthoMCL 1 0.900 - - OOG6_100189
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X82
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.870

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