DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and Nrk

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster

Alignment Length:	773	Identity:	195/773 - (25%)
Similarity:	293/773 - (37%)	Gaps:	232/773 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   322 GYEPNYTNKTCTEC-----------PLGTFKSPEVTKCTPCPPNSNASKTGSPFCK-------CA 368
            ||...|:.|.|.|.           |.|.:|:.:||  |.......:..||  .|:       ||
  Fly    68 GYCAPYSGKVCKEYLTGQVWYSLEDPTGGWKNEQVT--TALWDELISDLTG--LCREAAEKMLCA 128

  Fly   369 SGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI 433
               |..||      |:..........|.|.|                 ...|:.:..::|.|.
  Fly   129 ---YAFPN------CHMEGGRAVKAPLCFED-----------------CQATHLQFCYNDWVL-- 165

  Fly   434 KCNICSPNVVYNPSTDTFNETK--ITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVS 496
                    :......:.|.:::  ..|.|             .:|:.|.|...|..| .|.:.::
  Fly   166 --------IEEKKERNMFIKSRGHFRLPN-------------CSSLPHYNASMRRPN-CSYIGLT 208

  Fly   497 DIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWD-----KPVQ 556
            ::..|..|.        :.:.|.......|.:|..|.:...|            ||     |..|
  Fly   209 ELKESEVSY--------DCRNGNGRFYMGTMNVSKSGIPCQR------------WDTQYPHKHFQ 253

  Fly   557 SDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSY------ 615
            .  ||.|::                            |||...|     |:...|...:
  Fly   254 P--PLVFHQ----------------------------LLEGENY-----CRNAGGEEPHPWCYTV 283

  Fly   616 -------------------SNMIYAQTLQSVGSVYDDSVQIRFIAG----AIVTGVLFLVIFIIA 657
                               .|.:...|...:...:..|: |..:||    ||||  |.|:|.::
  Fly   284 DESVRWQHCDIPMCPDYVDPNAVDLNTPIKMEKFFTPSM-IFLLAGIGFVAIVT--LHLMILLV- 344

  Fly   658 TVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVN-SM---------------------DTTPIVKK 700
               :..|||:|         ...|...|:.|.: ||                     :|..:.|.
  Fly   345 ---YKLSKHKD---------YSQPAGAATAECSVSMRGGGDCGGNLNTSRETLGGNGNTNTLAKW 397

  Fly   701 LHLNVTTPLFGNSRSYVDPHTYED-----PNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRL 760
            ..:..|..:..|..:........|     ||..:.:.  |.....|.....:|.|.||.|.:.|
  Fly   398 GTIRSTATIHSNCVALTTVTNVSDAKGTKPNARLEKL--EYPRGDIVYVRSLGQGAFGRVFQAR- 459

  Fly   761 KIPPNFV---QDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITE 822
              .|..|   :|:.||:|.||..:|::.:.||..||.::.:|||||::.|.||.....|:.::.|
  Fly   460 --APGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFE 522

  Fly   823 YMENGSLDTFLRV----------NDGKFQ--TLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVL 875
            ||..|.|..|||.          ...:.|  .|.|:.|...||:||.|||:..:||||||.||.|
  Fly   523 YMAPGDLSEFLRACSPYATHQAPTQDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCL 587

  Fly   876 VNAQLICKIADFGLSREIENASDAYTTRGGK---IPVRWTAPEAIAFRKFTSASDVWSYGVVLWE 937
            :|..:..||||||||.:| ...|.|  :|.:   ||:||...|:|.:.||:..||||:||:.|||
  Fly   588 INEHMAVKIADFGLSHKI-YLQDYY--KGDENDFIPIRWMPLESILYNKFSLESDVWAYGICLWE 649

  Fly   938 VMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASI 995
            |.|:..:||:..::::|||.|::|..|..|.:.|.::|.||..||.::.:.||.||.|
  Fly   650 VFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEI 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	9/90 (10%)
		FN3	536..623	CDD:238020	15/116 (13%)
		EphA2_TM	644..736	CDD:291255	22/118 (19%)
		PTKc_EphR	736..1002	CDD:270629	109/278 (39%)
		Pkinase_Tyr	741..999	CDD:285015	109/273 (40%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308	36/197 (18%)
		KR	217..299	CDD:214527	18/136 (13%)
		PTKc_Musk	435..713	CDD:133181	110/279 (39%)
		Pkinase_Tyr	441..707	CDD:285015	108/271 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455340
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940