Protein Alignment Eph and Ror1

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: NP_001102141.1
• Gene: Ror1 / 362550
• RGDID: 1559469
• Length: 937
• Species: Rattus norvegicus
• Alignment Length: 737
• Identity: 194/737 - (26%)
• Similarity: 301/737 - (40%)
• Gaps: 169/737 - (22%)

  Fly   354 NSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSS 418
            |.:.:.||...|...||.......|.....:.||  ||                ::|..::.:..
  Rat   120 NLDTTDTGYFQCVATSGKKVVSTTGVLFVKFGPP--PT----------------ASPGSSDEYEE 166

  Fly   419 ETNSKIYHSDIVYKIKC-NICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINE 482
            :...:.|..     |.| .......||..|.....|.:..:|     ..:|:    |.:.||:
  Rat   167 DGFCQPYRG-----IACARFIGNRTVYMESLHMQGEIENQIT-----AAFTM----IGTSSHL-- 215

  Fly   483 FKRHSNESSLVAVSDIVF------SNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILA 541
                |::.|..|:..:..      ..||.:..|.||..   .:.|::   |:||..|.:   |.|
  Rat   216 ----SDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCR---DECEVL---ENVLCHTEY---IFA 267

  Fly   542 ITNKDADLEWDKPVQSDFPL-EFYEVRWFPKVEL---DAINKSALNTKETKAHIVGLLENTEYGF 602
            .:|....:....|...|.|. |..|.....::.:   |.|||:......|.....|.:..|:.|.
  Rat   268 RSNPMILMRLKLPNCEDLPQPESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGR 332

  Fly   603 Q----------------VRCKTNNGFGSY---------------------SNMIYAQTLQSVGSV 630
            |                :|....||..||                     |::.......|..|.
  Rat   333 QCQPWNSQYPHTHSFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSK 397

  Fly   631 YDDSVQIRFI---AGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSM 692
            ..:.::|.:|   :.||...:.||..||...              ::....|.|
  Rat   398 EKNKMEILYILVPSVAIPLAIAFLFFFICVC--------------RNNQKSPSP----------- 437

  Fly   693 DTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCR 757
               |:.::     ..|:.|.:......:.|:..::     |:|:..:.:.....:|...||.:.:
  Rat   438 ---PVQRQ-----PKPVRGQNVEMSMLNAYKPKSK-----AKELPLSAVRFMEELGECTFGKIYK 489

  Fly   758 GRLKIPPNFVQDID----VAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVM 818
            |.|.:|     .:|    |||||||..::.:...:|..|||:|.:..|||::.|.|.||:..||.
  Rat   490 GHLYLP-----GMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVC 549

  Fly   819 IITEYMENGSLDTFLRV------------NDGKFQT-------LQLIVMLRGIASGMSYLSDMNY 864
            ::.|||..|.|..||.:            .||..::       |.:.:.   ||:||.|||...:
  Rat   550 MLFEYMNQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQ---IAAGMEYLSSHFF 611

  Fly   865 VHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRG-GKIPVRWTAPEAIAFRKFTSASDV 928
            ||:||||||:|:..||..||:|.||||||.:| |.|..:. ..:|:||..||||.:.||:|.||:
  Rat   612 VHKDLAARNILIGEQLHVKISDLGLSREIYSA-DYYRVQSKSSLPIRWMPPEAIMYGKFSSDSDI 675

  Fly   929 WSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFA 993
            ||:||||||:.|:|.:||:.:|||:||:.:.|...||...|||..:|.||.:||.:..:.||.|.
  Rat   676 WSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFK 740

  Fly   994 SIVSTLDNLARQPQSLLTTRPS 1015
            .|...|.:.........:|.||
  Rat   741 DIHVRLRSWEGLSSHTSSTTPS 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	14/89 (16%)
		FN3	536..623	CDD:238020	23/127 (18%)
		EphA2_TM	640..738	CDD:464211	15/100 (15%)
		PTKc_EphR	736..1002	CDD:270629	113/289 (39%)
		SAM_1	1029..1092	CDD:425739
Ror1	NP_001102141.1	IG_like	66..148	CDD:214653	7/27 (26%)
		Ig strand B	75..79	CDD:409570
		Ig strand C	88..92	CDD:409570
		Ig strand E	114..118	CDD:409570
		Ig strand F	128..133	CDD:409570	1/4 (25%)
		Ig strand G	141..144	CDD:409570	0/2 (0%)
		CRD_TK_ROR1	166..307	CDD:143576	34/169 (20%)
		KR	311..393	CDD:214527	11/81 (14%)
		PTKc_Ror1	467..749	CDD:270672	114/290 (39%)