Protein Alignment Eph and IGF1R

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: XP_016877626.1
• Gene: IGF1R / 3480
• HGNCID: 5465
• Length: 1392
• Species: Homo sapiens
• Alignment Length: 1123
• Identity: 245/1123 - (21%)
• Similarity: 405/1123 - (36%)
• Gaps: 389/1123 - (34%)

  Fly   164 IRDCSLFPGNAL----------SCKETF--------------------SLLFYEFDAATREPPPW 198
            ::.|::|.||.|          |..|.|                    ||.|.:
Human   375 LQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLK----------- 428

  Fly   199 QTDSYRLIARIAAGEGRF------NQNSDVDINTEVKSIAVNKKGVYFAFRDQGACISVLAVKVY 257
               :.|||......||.:      |||.....:.:.:::.:....:||||..: .|:|    ::|
Human   429 ---NLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPK-LCVS----EIY 485

  Fly   258 YI------------------------TCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYE 298
            .:                        :|.:   :..||..|.|.:...||....         |.
Human   486 RMEEVTGTKGRQSKGDINTRNNGERASCES---DVLHFTSTTTSKNRIIITWHR---------YR 538

  Fly   299 TPTY-------------------------LCKGDGKWTILTGGCRCKAGYEPNY----------- 327
            .|.|                         .| |...|.::..........||..
Human   539 PPDYRDLISFTVYYKEAPFKNVTEYDGQDAC-GSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQY 602

  Fly   328 ----------------------------TNKTCTECPLGTF-----KSPEVTKCTPCP--PNSNA 357
                                        ||.:....||...     .|..:.|..| |  ||.|.
Human   603 AVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNP-PSLPNGNL 666

  Fly   358 SKTGSPFCKCASGFY-----RHPNDG---RHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNE 414
            |            :|     |.|.||   ||..| |....|..   .:.|.|..|...:...|.|
Human   667 S------------YYIVRWQRQPQDGYLYRHNYC-SKDKIPIR---KYADGTIDIEEVTENPKTE 715

  Fly   415 SFSSETN---------------------SKIY----HSDI-----------VYKIKCNICSPNVV 443
            ....|..                     .|::    |:.|           |.::.....|....
Human   716 VCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSR 780

  Fly   444 YNPSTDTFNET--------------------KITLTNLEPVTTYTVQIHAINSVSHINEFKRHSN 488
            ...:.||:|.|                    :..::||.|.|.|.:.||:.|          |..
Human   781 NTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCN----------HEA 835

  Fly   489 ESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEI--VFTTESVLLSTVFNLRILAITNKDADLEW 551
            |....:.|:.||:.|    :|.:      |..:|  ..|.|....:::|             |:|
Human   836 EKLGCSASNFVFART----MPAE------GADDIPGPVTWEPRPENSIF-------------LKW 877

  Fly   552 DKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAH---IVGLLENTEYGFQVRCKTNNGFG 613
            .:|...:..:..||:::..:||   ..:..::.:|.:.:   .:..|....|..:::..:.:|.|
Human   878 PEPENPNGLILMYEIKYGSQVE---DQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNG 939

  Fly   614 SYSNMIYAQTLQSVGSVYDDSVQIRF---IAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKST 675
            |:::.::.......|  |::.:.:..   :|..::.|.|.:::::     |.|.::...|
Human   940 SWTDPVFFYVQAKTG--YENFIHLIIALPVAVLLIVGGLVIMLYV-----FHRKRNNSRL----- 992

  Fly   676 NHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANY 740
                      .|.|           |:.:|....|..:..||       |::  .|.|||    .
Human   993 ----------GNGV-----------LYASVNPEYFSAADVYV-------PDE--WEVARE----K 1023

  Fly   741 ITIEAIIGGGEFG----DVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDH 801
            ||:...:|.|.||    .|.:|.:|..|    :..|||||:...:|.:.|.:||.|||:|.:|:.
Human  1024 ITMSRELGQGSFGMVYEGVAKGVVKDEP----ETRVAIKTVNEAASMRERIEFLNEASVMKEFNC 1084

  Fly   802 PNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQ--------TLQLIVMLRG-IASGMS 857
            .:|:.|.|||::..|.::|.|.|..|.|.::||....:.:        :|..::.:.| ||.||:
Human  1085 HHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMA 1149

  Fly   858 YLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGK--IPVRWTAPEAIAFR 920
            ||:...:|||||||||.:|......||.|||::|:|....  |..:|||  :||||.:||::...
Human  1150 YLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETD--YYRKGGKGLLPVRWMSPESLKDG 1212

  Fly   921 KFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQ 985
            .||:.|||||:||||||:.:..|:||...||:.|::.:.:|..|..|.:||:.|::||..|||..
Human  1213 VFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYN 1277

  Fly   986 RTHRPTFASIVSTL-----------------DNLARQPQSL-----------------LTTRPSP 1016
            ...||:|..|:|::                 :|...:|:.|                 .::.|.|
Human  1278 PKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLP 1342

  Fly  1017 ESDGNHILDGQRGQNIFI 1034
            :....|..:...|..:.:
Human  1343 DRHSGHKAENGPGPGVLV 1360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	26/155 (17%)
		FN3	387..476	CDD:238020	23/144 (16%)
		FN3	536..623	CDD:238020	13/89 (15%)
		EphA2_TM	640..738	CDD:464211	18/97 (19%)
		PTKc_EphR	736..1002	CDD:270629	107/297 (36%)
		SAM_1	1029..1092	CDD:425739	1/6 (17%)
IGF1R	XP_016877626.1	Recep_L_domain	76..186	CDD:460032
		Furin-like	200..355	CDD:395614
		Recep_L_domain	377..492	CDD:460032	26/133 (20%)
		FN3	519..631	CDD:238020	14/121 (12%)
		FN3	636..>680	CDD:238020	13/56 (23%)
		FN3	860..949	CDD:238020	16/104 (15%)
		PTKc_InsR_like	1017..1293	CDD:173625	111/285 (39%)