Protein Alignment Eph and Ror

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: NP_476962.1
• Gene: Ror / 34367
• FlyBaseID: FBgn0010407
• Length: 685
• Species: Drosophila melanogaster
• Alignment Length: 738
• Identity: 198/738 - (26%)
• Similarity: 314/738 - (42%)
• Gaps: 193/738 - (26%)

  Fly   384 YSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYN--- 445
            ||......:|.|||             .|.:..|...:|:||.    ::....||.   :||
  Fly     4 YSAFIVCISLVLLF-------------TKKDVGSHNVDSRIYG----FQQSSGICH---IYNGTI 48

  Fly   446 -----PSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSN--- 502
                 .:...|....:|:.:||.      ::.|...|  |.|.|..:....:.|:..:.||:
  Fly    49 CRDVLSNAHVFVSPNLTMNDLEE------RLKAAYGV--IKESKDMNANCRMYALPSLCFSSMPI 105

  Fly   503 ------TSLL---NIPLDLNEVK--------TGQAEI----VFTTESVLLSTVFNLRILA----- 541
                  |:||   |:..:..::|        |...:|    :|..:|.:...||:..|.:
  Fly   106 CRTPERTNLLYFANVATNAKQLKNVSIRRKRTKSKDIKNISIFKKKSTIYEDVFSTDISSKYPPT 170

  Fly   542 --------ITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGL---L 595
                    |..::.:|..::..|.::.:    .:..|.:.:..:.......:......:|:   :
  Fly   171 RESENLKRICREECELLENELCQKEYAI----AKRHPVIGMVGVEDCQKLPQHKDCLSLGITIEV 231

  Fly   596 ENTEYGFQVRCKTNNGFGSYS--------------------NMIYAQTLQSVGSV------YDDS 634
            :.||..:.....|..|..:.|                    .:|.....::.|||      :.||
  Fly   232 DKTENCYWEDGSTYRGVANVSASGKPCLRWSWLMKEISDFPELIGQNYCRNPGSVENSPWCFVDS 296

  Fly   635 VQIRFI-------------------AGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPL 680
            .:.|.|                   ..||:  ::|::||  |.:.|.|         ::..|..:
  Fly   297 SRERIIELCDIPKCADKIWIAIVGTTAAII--LIFIIIF--AIILFKR---------RTIMHYGM 348

  Fly   681 PLDYASNEVNSMDTTPIVKKLHLNVTTP-----LFGNSRSYVDPHTYEDP--------------N 726
                              :.:| |:.||     ::|||:.    :..:|.              |
  Fly   349 ------------------RNIH-NINTPSADKNIYGNSQL----NNAQDAGRGNLGNLSDHVALN 390

  Fly   727 QAIREFAREIDANYITIEAI-----IGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKAR 786
            ..:.|....:..|:.|::.:     :|.|.||.|.:|:| :.|| ...|.||||.||..:|.|.:
  Fly   391 SKLIERNTLLRINHFTLQDVEFLEELGEGAFGKVYKGQL-LQPN-KTTITVAIKALKENASVKTQ 453

  Fly   787 CDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVN---DGK-FQTLQLIV 847
            .||..|..::....|.|::.:.|||....|..::.|||.||.|..||..|   :|| ...|:.:.
  Fly   454 QDFKREIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGKSLSQLEFLQ 518

  Fly   848 MLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRG-GKIPVRW 911
            :...|:.||.|||..:||||||||||.|||..|:.||:||||||:| .:||.|..:. ..:||||
  Fly   519 IALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDI-YSSDYYRVQSKSLLPVRW 582

  Fly   912 TAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQ 976
            ...|:|.:.|||:.|||||:||||||:.|||.:||:.:|||:||..|.....|.||.:||.|:|.
  Fly   583 MPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSAPENCPTAVYS 647

  Fly   977 LMLDCWQKQRTHRPTFASIVSTL 999
            ||::||.:|...||||..|.:.|
  Fly   648 LMIECWHEQSVKRPTFTDISNRL 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	18/96 (19%)
		FN3	536..623	CDD:238020	12/122 (10%)
		EphA2_TM	640..738	CDD:464211	20/135 (15%)
		PTKc_EphR	736..1002	CDD:270629	122/274 (45%)
		SAM_1	1029..1092	CDD:425739
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568	33/203 (16%)
		KR	235..312	CDD:214527	12/76 (16%)
		PTKc_Ror	404..673	CDD:270642	121/270 (45%)