Protein Alignment Eph and Btk

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Alignment Length: 269
• Identity: 104/269 - (38%)
• Similarity: 163/269 - (60%)
• Gaps: 22/269 - (8%)

  Fly   747 IGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVV 811
            :|.|:||.|.||:.:      ..||.|:|.:|.|:..:.  ||:.||.:|.:..|||::.|.||.
  Fly   532 LGSGQFGVVRRGKWR------GSIDTAVKMMKEGTMSED--DFIEEAKVMTKLQHPNLVQLYGVC 588

  Fly   812 TRSNPVMIITEYMENGSLDTFLRVNDGKFQTL-----QLIVMLRGIASGMSYLSDMNYVHRDLAA 871
            ::..|:.|:||||::|||..:||.::   :||     .|:.|...::.||:||...||:||||||
  Fly   589 SKHRPIYIVTEYMKHGSLLNYLRRHE---KTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAA 650

  Fly   872 RNVLVNAQLICKIADFGLSREIENASDAYTTRGG-KIPVRWTAPEAIAFRKFTSASDVWSYGVVL 935
            ||.||.::.:.|:|||||:|.:  ..|.||:.|| |.|::|..||.:.:.:|:|.||||:|||::
  Fly   651 RNCLVGSENVVKVADFGLARYV--LDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLM 713

  Fly   936 WEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLD 1000
            ||:.:.|:.||....|.:|::.:::|..|..|..|.:.:|.:|..||......||.|..:   :|
  Fly   714 WEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVL---MD 775

  Fly  1001 NLARQPQSL 1009
            .||...|:|
  Fly   776 QLALVAQTL 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020
		FN3	536..623	CDD:238020
		EphA2_TM	640..738	CDD:464211
		PTKc_EphR	736..1002	CDD:270629	100/260 (38%)
		SAM_1	1029..1092	CDD:425739
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702
		SH2_Tec_family	403..505	CDD:198188
		PTKc_Tec_like	521..778	CDD:173637	100/261 (38%)