Protein Alignment Eph and Pvr

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: NP_001162911.1
• Gene: Pvr / 34127
• FlyBaseID: FBgn0032006
• Length: 1577
• Species: Drosophila melanogaster
• Alignment Length: 1134
• Identity: 218/1134 - (19%)
• Similarity: 378/1134 - (33%)
• Gaps: 375/1134 - (33%)

  Fly   146 PFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYE--------FDAATREPP------ 196
            |.|.....:.::.:..||: ||.    .:...:..:.:.::.        |.:.:|..|
  Fly   331 PVIRSSVEHHVFTDTNFTL-DCE----QSAYVESVYGMEWFTPSRDENRIFASQSRTDPKTRNST 390

  Fly   197 --------------PWQTDSYRLIARIAAGEGRFNQNSDVDINTEVKSIAVNKKGVYFAFRDQGA 247
                          |..|..|:.:.         ..||:.::......|.|.|:..  ::.:.|.
  Fly   391 HQTGRSTLTVLNAQPSDTGLYKCVT---------TDNSNQNVQRATYRIKVLKQNE--SYLNVGE 444

  Fly   248 CISVLAVKVYYITCPAVTENFAHFNE------TPTGREI-------TIIEKQNGTCVD--NAEPY 297
            ......|:.|......:|.||..|..      .|.|.|:       .|:..:..|.:.  ||:..
  Fly   445 PSGHYNVQEYANRTIQMTANFEGFPTPSFSWFKPDGTEVRQSENNFKILSTELSTMLQVLNAQLQ 509

  Fly   298 ETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKSPEV-------TKCT--PCPP 353
            ::.||:.:|...:.::          :..| |.:..:.|........|       .:||  ..||
  Fly   510 DSGTYVLRGSNSFGVV----------QREY-NVSVMDAPALKMSDAYVQVGSVARLECTVRSYPP 563

  Fly   354 NSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSS 418
                        ...:.|:|        ||...|..||...|   :|     ::|.|::.|.:..
  Fly   564 ------------AIVTFFFR--------PCSLEPQWPTCSVL---NQ-----NFSLPSEQEKYQF 600

  Fly   419 ETNSKIYHSDI--VYKIKCNICSP--------NVVYNPSTDTFNETKITLTNL-EPVTTYTV-QI 471
            :|..:.....:  :|::......|        |::......|..:..:.|.|: |.:|.|.. :.
  Fly   601 QTRPRPGKLSVERIYEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKD 665

  Fly   472 HAINSVSHIN------EFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVL 530
            |.|....::|      .:....|....:...|:..|         |...::|...:..:.: :|.
  Fly   666 HKIAKEDNVNFTCEALAYHFDGNLKWFINGEDLKES---------DSVHIETSHTKYSYKS-TVH 720

  Fly   531 LSTV-------------FNLRILAITNKDADL--------EW-----------DKPVQSDFPLEF 563
            ::|:             .|.:....::::.||        :|           .:.:.....||.
  Fly   721 ITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELEC 785

  Fly   564 YE-------VRWFPKVELDAINKSALN---TKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNM 618
            ..       ||||.  :...:.:|.|.   .||:|..|..|....|..:  :|...|........
  Fly   786 ASTAVPVAIVRWFK--DDKEVTESKLRHIIEKESKLLITHLYPGDEGVY--KCVVENRLDRIERS 846

  Fly   619 IYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLF---LVIFIIATVYFMRSKHQDDLDKKSTNHLPL 680
            .              :|.|..:.|..:..|.|   |.:.:|....|:..::|    |:...||.|
  Fly   847 F--------------TVVISDLPGISMAWVWFGVILFLILIGLCVFLAVRYQ----KEHKRHLAL 893

  Fly   681 PLDYASN-EVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIE 744
            .....:| |..::.        |:|....|  :.::.:.|:..|      .||.||    .:.:.
  Fly   894 KAAGLANFEEGAVG--------HINPDLTL--DEQAELLPYNRE------FEFPRE----NLKLG 938

  Fly   745 AIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIM---GQFDHPNVIY 806
            ..:|.|.||.|.:|..|..........||:|.:|..:..:.....::|..||   ||  |.||:.
  Fly   939 KQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQ--HLNVVN 1001

  Fly   807 LQGVVTRS---NPVMIITEYMENGSLDTFL-------------------------RVNDG----- 838
            |.|.||::   ..:|:|.||...|::..||                         |::|.
  Fly  1002 LLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHR 1066

  Fly   839 -------KF-------------------------------------------------------- 840
                   |:
  Fly  1067 DTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDT 1131

  Fly   841 --------------------------------------QTLQLIVMLRGIASGMSYLSDMNYVHR 867
                                                  .|:.||.....:|.||.|||....:|.
  Fly  1132 CATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHG 1196

  Fly   868 DLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYG 932
            ||||||:|:....:.||.||||:|.:....:...:..||:|::|.|.|:::...|::.|||||||
  Fly  1197 DLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYG 1261

  Fly   933 VVLWEVMSYGERPYWNWS-NQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIV 996
            :||||:.|..:.||.... ||::...:..|||:..|....:.||::||:||:|....||.||.:.
  Fly  1262 IVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELE 1326

  Fly   997 STLDNLARQPQSLLTTRPSPESDGNHILD 1025
            ....|:.            .|...:|.||
  Fly  1327 KRFANML------------GEDVASHYLD 1343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	20/141 (14%)
		FN3	387..476	CDD:238020	20/100 (20%)
		FN3	536..623	CDD:238020	20/115 (17%)
		EphA2_TM	640..738	CDD:464211	22/101 (22%)
		PTKc_EphR	736..1002	CDD:270629	95/403 (24%)
		SAM_1	1029..1092	CDD:425739
Pvr	NP_001162911.1	IG_like	346..432	CDD:214653	13/99 (13%)
		Ig strand C	363..366	CDD:409353	0/2 (0%)
		Ig strand E	396..400	CDD:409353	0/3 (0%)
		Ig strand F	410..415	CDD:409353	1/4 (25%)
		Ig strand G	425..428	CDD:409353	0/2 (0%)
		Ig	458..533	CDD:472250	16/85 (19%)
		Ig strand B	459..463	CDD:409353	0/3 (0%)
		Ig strand C	472..476	CDD:409353	0/3 (0%)
		Ig strand E	497..503	CDD:409353	1/5 (20%)
		Ig strand F	513..518	CDD:409353	2/4 (50%)
		Ig	671..>742	CDD:472250	9/80 (11%)
		Ig strand B	674..678	CDD:409353	1/3 (33%)
		Ig strand C	687..691	CDD:409353	1/3 (33%)
		Ig strand E	717..721	CDD:409353	1/4 (25%)
		Ig strand F	731..736	CDD:409353	0/4 (0%)
		Ig	779..851	CDD:472250	17/89 (19%)
		Ig strand B	781..785	CDD:409570	1/3 (33%)
		Ig strand C	794..798	CDD:409570	2/3 (67%)
		Ig strand E	816..821	CDD:409570	2/4 (50%)
		Ig strand F	831..836	CDD:409570	1/6 (17%)
		Ig strand G	844..847	CDD:409570	0/2 (0%)
		Protein Kinases, catalytic domain	927..1332	CDD:473864	100/416 (24%)