DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and CG3277

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	760	Identity:	166/760 - (21%)
Similarity:	272/760 - (35%)	Gaps:	276/760 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   445 NPSTD---TFNETKITL-------------TNLEPVTTYTVQIHAINSV----SHINEFKRHSNE 489
            ||:.|   |...|.:||             .||...|:|.|.:.|:|:.    :..:|:......
  Fly    75 NPNPDGEITELTTNVTLYMEKIPRLQVRWQDNLPQGTSYNVLVSAVNNSRCPDAPCSEYGIKEKN 139

  Fly   490 SSLVAVSDIVFSNTSLLNIPLDLN-EVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDK 553
            :|         :.|..:|:|::.| .|::.....:|..:..::....|    |:..:.|.:...:
  Fly   140 AS---------AETHSVNLPVNPNLNVESVDCNYMFGCQYQVIVETSN----AMVRRSARVYIPQ 191

  Fly   554 PVQSDFPLEFYEVRWFPKV---------ELDAINKSALNT----KETKAHIVGLLENTEYGFQVR 605
            .::.....:.....  |||         |..:||.|.|.:    ||..:|:...|...:...::.
  Fly   192 CLEGKCSCQLAPTP--PKVLAVAKMLSNETISINLSILASELLRKEQDSHLHETLRTYKMQLKIN 254

  Fly   606 CKTNN------------------------------------GFGSYSNMIYAQTLQSVGSVYD-- 632
            .:||.                                    |.|:......:.:||:|  :.|
  Fly   255 EETNPSLPWGGVLKHLMTRVYKLSELNFRATPKGFEGVMKLGLGTQLKEKASLSLQAV--IIDPT 317

  Fly   633 -----------------------DSVQIRFIAGAIVTGVLFLVIFIIATVYFM-----RSKHQDD 669
                                   |||     :.:|:.....|:..|:|.:..:     |::....
  Fly   318 GCEGPRSVTKVPVPANPVLLTEGDSV-----SNSIIVMSAMLIAIILAGLIMLLLRRRRARTTAK 377

  Fly   670 LDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHT-----------YE 723
            |.|:...::.   .:|::.:...|          ||         :|||.:.           :|
  Fly   378 LRKQEQIYIQ---TFATSAIEMED----------NV---------NYVDKYVEKSQVLGLADIFE 420

  Fly   724 DPNQAIREFAREIDANYITIEAIIGGGEFGDV----------CRGRLKIPPNFVQDIDVAIKTLK 778
            .|:.||:            |..::|.|.||.|          .||          ...||:|.||
  Fly   421 VPHSAIQ------------IGRMLGEGAFGQVHEATAINLRRMRG----------TTIVAVKQLK 463

  Fly   779 PGSSEKARCDFLTEASIM-GQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLR-------- 834
            |........::|.|..:: |...|.||:...|..|...|.::|.||:..|:|.::||
  Fly   464 PNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASK 528

  Fly   835 --------------------VNDGKFQTLQLIVM-----------------LRG----------- 851
                                .:..|.|::..|.:                 :.|
  Fly   529 LRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAET 593

  Fly   852 --------------------------IASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLS 890
                                      ||:||.:|.:....||||||||||:::....||:|||||
  Fly   594 TYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLS 658

  Fly   891 REIENASDAYT-TRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDV 954
            |.     ..|| ||..|:|:||.:.|||....::|.||:|:|||||||:.:.|..||...||.::
  Fly   659 RH-----GIYTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISNDEL 718

  Fly   955 IKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTL 999
            |..:..|.||..|..|...:|.:||.||.::...||||.::...|
  Fly   719 IPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYKVL 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	13/46 (28%)
		FN3	536..623	CDD:238020	19/135 (14%)
		EphA2_TM	644..736	CDD:291255	18/107 (17%)
		PTKc_EphR	736..1002	CDD:270629	100/358 (28%)
		Pkinase_Tyr	741..999	CDD:285015	99/351 (28%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	100/363 (28%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	98/347 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455309
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.030