DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and Ddr

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001014474.3	Gene:	Ddr / 3346209	FlyBaseID:	FBgn0053531	Length:	1054	Species:	Drosophila melanogaster

Alignment Length:	1021	Identity:	238/1021 - (23%)
Similarity:	388/1021 - (38%)	Gaps:	268/1021 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 NNWLWSP--FIDRGSANRLYIE-----IQFTIRDCSLF-PGNALSCKETFSLLFYEFDAATREPP 196
            |...|.|  .:.||....|.::     :...||....| .|......|.:.:.:
  Fly   145 NGGAWCPKHMVSRGLTEYLQVDLLGVHLVSAIRTQGRFGKGQGQEYTEAYVIEY----------- 198

  Fly   197 PWQTDSYRLIA-RIAAGE----GRFNQNSDVDINTEVKSIAVNKKGVY-FAFRDQGACISVLAVK 255
             |:....:.|. |...|:    |..|..|:|: |....|:..:|..:| ::..|:..|:     :
  Fly   199 -WRPGLKKWIRWRSLQGKEVLPGNINTYSEVE-NVLQPSVFASKVRLYPYSQYDRTVCL-----R 256

  Fly   256 VYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEP----YETPTYLCKGDGKWTILTGG 316
            ...:.| |..|....:: .|.|       .|.|..:|.::.    ||...:...|.|:   |..|
  Fly   257 AEIVGC-AWEEGIVSYS-IPKG-------MQRGMDIDLSDKTYDGYEEGDHYVNGLGQ---LVDG 309

  Fly   317 CRCK-----------AGYE-PNYTNKTCTECPLGTFKSPEVTKCTPCPPNSNA--SKTGSPFCKC 367
            .|.|           .||| ..:.|.|....|:......|..:      |.:|  ..|.:.|.|.
  Fly   310 QRGKDNFRADINGLGKGYEWIGWRNDTLLGRPVEIIFEFETVR------NLSAVIIHTNNMFSKD 368

  Fly   368 ASGFYRHPN-----DGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYH- 426
            ...|. |..     .|||..  ..|...:.:..|.:|.                :.:...|::|
  Fly   369 VQVFV-HAKVFFSIGGRHFS--GEPVQFSYMPDLVLDH----------------ARDVTIKLHHR 414

  Fly   427 ------------------SDIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHA 473
                              |:|.:     |.:| ||.|.:.:..|..|.::|:..|:....|.
  Fly   415 LGRYVQLHLYFAARWMMISEITF-----ISAP-VVGNFTDELANGEKQSVTSEYPLQRDEVG--- 470

  Fly   474 INSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTT--ESVLLSTVFN 536
             .::|...|..:|:.:         |.|..     |:|..|.:|....::.|.  ..::|...|.
  Fly   471 -RAISSGGERSQHTTQ---------VISPK-----PIDHQEPETSFVGVIITVLGTIIMLLVAFI 520

  Fly   537 LRILAITNKDADLEWDKPVQS-DFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEY 600
            |.|:|         .:|.|:| :..|:.::..:.|    |.:|.:.:      ..:|..:::.|.
  Fly   521 LLIVA---------RNKHVRSRENGLDAFQHNFSP----DTLNGNGV------LKVVTTMDDNES 566

  Fly   601 GFQVRCKTNNGFGS--YSNMIYAQTL-----QSVGSVYDDSVQIRFIAGAIVTGVLFL------- 651
            ........:..|.:  |::...|..:     |.|...|.|...|.....|:......|
  Fly   567 SIDKNSLYHEPFNANMYTSAASACPMNDLQRQHVSPDYTDVPDIVCQDYAVPHMQQLLPNAPPCG 631

  Fly   652 ----------------VIFIIATVYFMRSKHQDDLDKKSTNHLPLPLD-----------YASNEV 689
                            ..|::||.....|.      :.|.|...|||.           ||:..|
  Fly   632 SGCGTGTGTGPGRGSSPEFVVATGKVTASA------RNSLNAATLPLPSPPVPPPLEKYYAATPV 690

  Fly   690 NS--MDTTP-------IVKKLHLNVTTPLFGNSRSYVDPHTY-------------EDPNQAIREF 732
            :|  |...|       .:.......|||..| ......||.|             |..|..::||
  Fly   691 SSKPMPVAPPGSQSSGSLSSSTTAATTPTSG-VVGVGKPHHYNLDMSANFADINEERANCQVQEF 754

  Fly   733 AREIDANYITIEAIIGGGEFGD--VCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASI 795
            .|:   :.:.:|. :|.|.||:  :|.      .|.:....||:.||:||:::..|.:|.::|..
  Fly   755 PRQ---SLVIVEK-LGSGVFGELHLCE------TNVLNATLVAVATLRPGANDHLRKEFRSKAKQ 809

  Fly   796 MGQFDHPNVIYLQGVVTRSNPVMIITEYME-NGSLDTFLRVNDGKFQTLQ---------LIVMLR 850
            :.|...|||..|.|...|..|:.|:.:|.. .|.|:.||:.:..:...|.         |:.:..
  Fly   810 LAQLSDPNVARLVGACLRDEPICIVQDYSHCLGDLNQFLQEHVAETSGLMAKKSLSFGCLVYIAT 874

  Fly   851 GIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFG--LSREIENASD-----AYTTRGGK-I 907
            .|||||.:|..||:||||||.|:.::..:|..|:...|  ::|. ..|||     .:|.|..: :
  Fly   875 QIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRS-AYASDYCQLEGFTGRQSQPM 938

  Fly   908 PVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYG-ERPYWNWSNQDVIKSIEKGYR-------L 964
            |:||.|.|::...|||:.|||||:.|.|||::::. |:||.:.|::.||::|...||       |
  Fly   939 PIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELL 1003

  Fly   965 PAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLD--NLARQPQS 1008
            |.|.:||..:|.||.:|||:..:.||:|..|...|.  ||..:||:
  Fly  1004 PMPPNCPREIYDLMCECWQRDESSRPSFREIHLYLQRKNLGFKPQT 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	25/133 (19%)
		FN3	387..476	CDD:238020	17/107 (16%)
		FN3	536..623	CDD:238020	15/89 (17%)
		EphA2_TM	644..736	CDD:291255	28/147 (19%)
		PTKc_EphR	736..1002	CDD:270629	98/295 (33%)
		Pkinase_Tyr	741..999	CDD:285015	97/285 (34%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
Ddr	NP_001014474.3	FA58C	106..262	CDD:214572	25/134 (19%)
		FA58C	109..261	CDD:238014	25/133 (19%)
		PTKc_DDR	753..1040	CDD:270644	101/297 (34%)
		TyrKc	759..1038	CDD:197581	97/286 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455259
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940