DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and sev

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_511114.2	Gene:	sev / 32039	FlyBaseID:	FBgn0003366	Length:	2554	Species:	Drosophila melanogaster

Alignment Length:	1045	Identity:	235/1045 - (22%)
Similarity:	400/1045 - (38%)	Gaps:	231/1045 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 DVAY-HNVNNWLWSPFIDRGSANRLYIEIQ--------------FTIRDCSLFPGN------ALS 176
            |..| :.|.||....:..|.......:|::              :..::|.|.|.:      |..
  Fly  1630 DSGYLYAVKNWSIRAYGRRRQQLEYTVELEPEEVRLLQAHNYQAYPPKNCLLLPSSGGSLLKATD 1694

  Fly   177 CKETFSLLFYEFDAATRE-PPPWQTDSYRLIARIA--------------AGEGRFNQNSDVDINT 226
            |:|...||......|:.: |.|.....|:|...:|              .|:........:::..
  Fly  1695 CEEQRCLLHLPMITASEDCPLPIPGVRYQLNLTLAKEPGSEEHDHGMEPLGQWLLGAGESLNLTD 1759

  Fly   227 EVKSIAVNKKGVYFAFRDQGACISVLAVKVYYI----TCPAVTENFAHFNETPTGREITIIEKQN 287
            .:........|:..:|..:...:..|.:....:    ..|:...||:....:|...|::.:..:.
  Fly  1760 LLPFTRYRVSGILSSFYQKKLALPTLVLAPLELLTASATPSPPRNFSVRVLSPRELEVSWLPPEQ 1824

  Fly   288 GTCVDNAEPYETPTYLCKGDG-------KW-----TILTGGCRCKAGYEPNYTNKTCTECPLGTF 340
               :.:...|.|..:..:.||       :|     .:.|.|.....|.:|            |:.
  Fly  1825 ---LRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGIKP------------GSG 1874

  Fly   341 KSPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAII 405
            .|..| :....|..||:|:.            .|......:|         .|.||.:...|..:
  Fly  1875 YSLWV-QAHATPTKSNSSER------------LHVRSFAELP---------ELQLLELGPYSLSL 1917

  Fly   406 SWS-APAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTV 469
            :|: .|....|...|..|.      ..:::.|:..            |.||:.:..|:|.|.|..
  Fly  1918 TWAGTPDPLGSLQLECRSS------AEQLRRNVAG------------NHTKMVVEPLQPRTRYQC 1964

  Fly   470 QI-------------HAINSV-SHINEFKRHSNESSLVAVSDIVFSNTSLL----NIPLDLNEVK 516
            ::             |....| ..:.:......:..|..:::.||..|...    ..|:.|..::
  Fly  1965 RLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARGNGAPIALYNLE 2029

  Fly   517 TGQAEIVFTTESVLLSTVFNLRILAITNKDADLE---W-DKPVQSDFPLEFYEVRWFPKVELDAI 577
            ..||.          |.:...|.....|....||   | ::||       ..|.:|     ||..
  Fly  2030 ALQAR----------SDIRRRRRRRRRNSGGSLEQLPWAEEPV-------VVEDQW-----LDFC 2072

  Fly   578 NKSALNTKETKAHIVGLLENTEYGFQVRCKT-NNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIA 641
            |.:.|:......|...||.     |:||.:: .:|:|.||..........|......|:.:..||
  Fly  2073 NTTELSCIVKSLHSSRLLL-----FRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSLVLAIIA 2132

  Fly   642 GAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVT 706
            .|.:.....|.:.::..|...|.:.:..|.:...:..           :::.|....::| :.|.
  Fly  2133 PAAIVSSCVLALVLVRKVQKRRLRAKKLLQQSRPSIW-----------SNLSTLQTQQQL-MAVR 2185

  Fly   707 TPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDID 771
            ...|..        |..|.:.|:   ..:|:.:.:.:...:|.|.||:|..|:||     .:|.:
  Fly  2186 NRAFST--------TLSDADIAL---LPQINWSQLKLLRFLGSGAFGEVYEGQLK-----TEDSE 2234

  Fly   772 ----VAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTF 832
                ||||:|:.|:||.|  :.|.||.:|..|.|.|::.|.|:...:..:.:|.|:||.|.|.::
  Fly  2235 EPQRVAIKSLRKGASEFA--ELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSY 2297

  Fly   833 LRV----------NDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLV-------NAQL 880
            ||.          ........:|:.|...:|:|.|||.||::||||||.||.||       :.:.
  Fly  2298 LRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRR 2362

  Fly   881 ICKIADFGLSREIENASDAYTTRG-GKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGER 944
            ..||.||||:|:|.. ||.|...| |.:||||.:||::....||:.||||::||:.||:::.|::
  Fly  2363 TVKIGDFGLARDIYK-SDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQ 2426

  Fly   945 PYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLA---RQP 1006
            ||...:|.:|:..:::|.||..|..|.|.||.|:|.||:.....||:|....:||..::   |:.
  Fly  2427 PYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRT 2491

  Fly  1007 QSLLTTRPS------PE----SDGNHILDGQRGQNIFISTDLWLEHIKMSRYCHHFKEANLINAQ 1061
            |....|..:      ||    .||..:.:.:.........:|.|..:.:       |:..|...:
  Fly  2492 QMASATADTVVSCSRPEFKVRFDGQPLEEHREHNERPEDENLTLREVPL-------KDKQLYANE 2549

  Fly  1062 QISRL 1066
            .:|||
  Fly  2550 GVSRL 2554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	25/166 (15%)
		FN3	387..476	CDD:238020	18/102 (18%)
		FN3	536..623	CDD:238020	23/91 (25%)
		EphA2_TM	644..736	CDD:291255	11/91 (12%)
		PTKc_EphR	736..1002	CDD:270629	106/287 (37%)
		Pkinase_Tyr	741..999	CDD:285015	103/279 (37%)
		SAM_1	1033..1092	CDD:278937	7/34 (21%)
		SAM	1039..1092	CDD:197735	6/28 (21%)
sev	NP_511114.2	fn3	439..520	CDD:278470
		FN3	826..921	CDD:238020
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		FN3	1799..1897	CDD:238020	22/125 (18%)
		FN3	1993..2111	CDD:238020	32/144 (22%)
		Pkinase_Tyr	2209..2481	CDD:285015	103/279 (37%)
		PTKc_c-ros	2213..2483	CDD:270640	105/277 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455273
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940