DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and Epha1

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	XP_008761105.1	Gene:	Epha1 / 312279	RGDID:	1304680	Length:	1010	Species:	Rattus norvegicus

Alignment Length:	1107	Identity:	393/1107 - (35%)
Similarity:	563/1107 - (50%)	Gaps:	198/1107 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LRTILLIIISIHFKLAHADQVVLLDT-TREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRS 128
            |..:||::.:.....|.|::|.|:|| |.:..|.|...|  |:.   ||.|  ....:.|.....
  Rat     9 LALLLLLLCAPLPPGARAEEVTLMDTSTAQGELGWLLDP--PET---GWSE--VQQMLNGTPLYM 66

  Fly   129 YVVCDVAY-HNVNNWLWSPFIDRG-SANRLYIEIQFTIRDCSLFPGNA--LSCKETFSLLFYEFD 189
            |..|.:.. .:.::||.|.:|.|| .|:|:::|:|||:|||..|||.|  |.|||||:|.:.|.|
  Rat    67 YQDCPIQEGGDTDHWLRSNWIYRGEEASRVHVELQFTVRDCKSFPGGAGPLGCKETFNLFYMESD 131

  Fly   190 ----AATREPPPWQTDSYRLIARIAAGEG---RFNQNSDVDINTEVKSIA-VNKKGVYFAFRDQG 246
                ...|.|      .::.:..:||.:.   |...:..|.:|.|..|:. :.::|:|.||.:.|
  Rat   132 QDVGIQLRRP------LFQKVTTVAADQSFTIRDLASGSVKLNVEHCSLGHLTRRGLYLAFHNPG 190

  Fly   247 ACISVLAVKVYYITCPAVTENFAHFNET---PTGREITIIEKQNGTCVDNAE----PYETPTYLC 304
            :|:::::|:|:|..|.......|||..|   |||    ::|.. |||:.:|:    ...||...|
  Rat   191 SCVALVSVRVFYQRCAETVHGLAHFPHTLPGPTG----LVEVA-GTCLSHAQISLGSSGTPRMHC 250

  Fly   305 KGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKSPEVT-KCTPCPPNSNASKTGSPFCKCA 368
            ..||:|.:..|.|:|:.|||.:..:..||.||.|.::....| .|..||.:|.|...||..|.|.
  Rat   251 SPDGEWLVPVGQCQCEPGYEESGGSVGCTACPTGFYRMDMNTLHCLKCPQHSVAESEGSTICTCE 315

  Fly   369 SGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI 433
            :|.||.|.:|..:.|..||:||.||: .....|...:.|..|       .:|..:   .||.|.:
  Rat   316 NGHYRAPGEGPQVACTRPPSAPQNLS-FSASGTQLSLRWEPP-------RDTGGR---QDIRYSV 369

  Fly   434 K-------------CNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKR 485
            :             |..|...|.::|:......:.:.:..|||...||..|.:.|.||.::
  Rat   370 ECLQCRGIAQDGGPCQPCGKGVHFSPAASGLTASTVQVEGLEPYANYTFTIKSQNRVSGLD---- 430

  Fly   486 HSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRI-LAITNKDADL 549
             |:..|..::|..:....||..:.|.|.:.:..|.|:.: ..|.|.:...||.. |.:.|:|.
  Rat   431 -SSSPSSASLSINMGQAESLSGLSLKLVKKEPRQLELTW-AGSRLQNPGGNLSYELHVLNQDE-- 491

  Fly   550 EWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGS 614
            ||.:.|     ||       |:|.|            ||     |..:|.|..:||..|..|.|.
  Rat   492 EWHQMV-----LE-------PRVLL------------TK-----LQPDTTYIVRVRTLTPLGPGP 527

  Fly   615 YSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLF---LVIFIIATVYFMRSK-----HQDDLD 671
            :|.....:|...|.         |.:.|..:..::|   |.|.::..:|..||:     .|....
  Rat   528 FSPDHEFRTSPPVS---------RSLTGGEIVAIIFGLLLGIALLIGIYVFRSRRGQRQRQQRQR 583

  Fly   672 KKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREI 736
            :::||            |:..|      ||.|          :.|||...||||.|...:||:|:
  Rat   584 ERTTN------------VDRED------KLWL----------KPYVDLQAYEDPAQGALDFAQEL 620

  Fly   737 DANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDI-DVAIKTLKPGSSEKARCDFLTEASIMGQFD 800
            |..::.::.:||.||||:|.||.|:||.   ||. .|||||||..|.:....:||.||:|||||:
  Rat   621 DPAWLIVDTVIGEGEFGEVYRGALRIPS---QDCKTVAIKTLKDTSPDGYWWNFLREATIMGQFN 682

  Fly   801 HPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVN--DGKF-----------QTL--------- 843
            ||:::.|:||:|:..|:|||||:||||:||.||:|.  :|:|           ||.
  Rat   683 HPHILRLEGVITKRKPIMIITEFMENGALDAFLKVRPAEGQFRRGHTLESHVSQTFHPLIYTFAL 747

  Fly   844 -----------QLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENAS 897
                       ||:.||.||||||:|||..|||||||||||:|||..|.||::||||:|.:::..
  Rat   748 LQEREDQLVPGQLVAMLLGIASGMNYLSGHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFD 812

  Fly   898 DAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGY 962
            ..|.|:|||||:|||||||||.|.||:||||||:|:|:|||:|:|::||...|||:|:||||.||
  Rat   813 GTYETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGY 877

  Fly   963 RLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLT--------TRPSPESD 1019
            |||.|:|||..||:||.:||...|..||.|..:.:.|:.|...|.||.|        |...|...
  Rat   878 RLPPPVDCPAPLYELMKNCWAYDRARRPHFLQLQAHLEQLLTDPHSLRTIANFDPRVTLRLPSLS 942

  Fly  1020 GNHILDGQRGQNIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKK 1084
            |:   ||..    :.|...|||.|:|.||..||:.|.|...:.:..|||:.|:.|||||.||||:
  Rat   943 GS---DGIP----YRSVSEWLESIRMKRYILHFRSAGLDTMECVLELTAEDLTQMGITLPGHQKR 1000

  Fly  1085 IL 1086
            ||
  Rat  1001 IL 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	61/187 (33%)
		FN3	387..476	CDD:238020	22/101 (22%)
		FN3	536..623	CDD:238020	24/87 (28%)
		EphA2_TM	644..736	CDD:291255	24/99 (24%)
		PTKc_EphR	736..1002	CDD:270629	154/299 (52%)
		Pkinase_Tyr	741..999	CDD:285015	152/291 (52%)
		SAM_1	1033..1092	CDD:278937	27/54 (50%)
		SAM	1039..1092	CDD:197735	26/48 (54%)
Epha1	XP_008761105.1	EphR_LBD_A1	28..204	CDD:198447	61/188 (32%)
		TNFRSF	252..>320	CDD:304602	25/67 (37%)
		CRD2	281..312	CDD:276900	11/30 (37%)
		fn3	335..426	CDD:278470	22/101 (22%)
		FN3	454..536	CDD:238020	30/113 (27%)
		EphA2_TM	<597..620	CDD:291255	11/32 (34%)
		PKc_like	620..918	CDD:304357	154/300 (51%)
		Pkinase_Tyr	625..914	CDD:285015	152/291 (52%)
		SAM	945..1010	CDD:197735	29/62 (47%)
		SAM_EPH-A1	946..1008	CDD:188941	28/61 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10591
eggNOG	1	0.900	-	-		E2759_KOG0196
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D397694at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100189
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X82
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.820