DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eph and Ephb6

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:NP_001101327.1 Gene:Ephb6 / 312275 RGDID:1306163 Length:1013 Species:Rattus norvegicus


Alignment Length:1077 Identity:351/1077 - (32%)
Similarity:540/1077 - (50%) Gaps:180/1077 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 VLLDTTREAT-LEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCDVA----YHNVNNWLWS 145
            ||||||.|.: :.|..||.|      ||.|.|..|..:.:. |::..|.||    ....:|||.:
  Rat    35 VLLDTTGETSEIGWLTYPPG------GWDEVSVLDDQRRLT-RTFEACHVAGLPPGSGQDNWLQT 92

  Fly   146 PFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAATREP------PPWQTDSYR 204
            .|::|..|.|.:|.:.|::|.||....:..:|:|||:|.:.:.|    ||      ..|....:.
  Rat    93 HFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQAD----EPDSPDSISAWHLKRWT 153

  Fly   205 LIARIAAGEG---------------RFNQNSDVDINTEVKSIA-VNKKGVYFAFRDQGACISVLA 253
            .:..|||.|.               |.:|...:.:|.:.:|.. :.::|.|.||:|.|||::::|
  Rat   154 KVDTIAADESFPASSSSSSWAVGPHRTDQRVGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVA 218

  Fly   254 VKVYYITCPAVTENFAHFNET-PTGREITIIEKQNGTCVDNAEPYE----------TPTYLCKGD 307
            ||::..|||:|...||.|.|| .:|.....:....||||.:|||.|          .|...|.|:
  Rat   219 VKLFSYTCPSVLRAFASFPETQASGAGGASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGE 283

  Fly   308 GKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKS-PEVTKCTPCPPNSNASKTGSPFCKCASGF 371
            |:|.:..|||||:.|::|...:|.|..||.|::|: |....|:|||..|::....:|.|.|..||
  Rat   284 GRWMVAVGGCRCQPGHQPARGDKLCQACPEGSYKALPGNVPCSPCPARSHSPDPAAPVCPCLQGF 348

  Fly   372 YRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAI-ISWSAPAKNESFSSETNSKIYHSDIVYKI-- 433
            ||..:|....||..||:||..  |.|..|.||: :.|..|       .|...:   .|:::.:  
  Rat   349 YRASSDPPEAPCTGPPSAPRE--LWFEVQGSALMLHWRLP-------QELGGR---GDLLFNVVC 401

  Fly   434 -------------KCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKR 485
                         .|..|...|.::|......|:::.:..|.....|.:::.|:|.||.:     
  Rat   402 KECGGHKEPSSGGMCRRCRDEVHFDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSEL----- 461

  Fly   486 HSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLE 550
             |.:....|..::..|:.....:|: :::|......|.                         :.
  Rat   462 -SPDPPQAAAINVSTSHEVPSAVPV-MHQVSRAANSIT-------------------------VS 499

  Fly   551 WDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSY 615
            |.:|.|::..:..|::|::.:.| |..:...:.::...|.:..|.....||||||.:|..|.|.|
  Rat   500 WPQPEQTNGNILDYQLRYYDQAE-DESHSFTMTSETNTATVTRLSPGHIYGFQVRARTAAGHGPY 563

  Fly   616 SNMIYAQTLQ--SVGSVYDDSVQIRFIAGAIVTGVLFLVI--FIIATVYFMRSKHQDDLDKKSTN 676
            ...:|.|||.  .:.|...:.:.:  :.|:|:..:.||::  ..:..|.|.|.       ::.|.
  Rat   564 GGKVYFQTLPQGELSSQLPEKLSL--VIGSILGALAFLLLAAITVLAVIFQRK-------RRGTG 619

  Fly   677 HLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYI 741
            :......|:|                     |..| .:.|:||.||:||.|||||.|||:|..||
  Rat   620 YTEQLQQYSS---------------------PGLG-VKYYIDPSTYDDPCQAIRELAREVDPTYI 662

  Fly   742 TIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIY 806
            .||.:||.|.||:|.||||:  |...::..|||:.|..|.:|..:..||..|:::|||.|||::.
  Rat   663 KIEEVIGAGSFGEVRRGRLQ--PRGRREQAVAIQALWAGGAESLKMTFLGRAALLGQFQHPNILR 725

  Fly   807 LQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAA 871
            |:||||||.|||::||.||.|.||:|||..:|:|.:|||:.|.||:|:.|.|||...:|||.|:|
  Rat   726 LEGVVTRSRPVMVLTELMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRALSA 790

  Fly   872 RNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLW 936
            |:||||:.|:||:|..|           ::.:|....:||.|||.|...|:|::|||||:|:::|
  Rat   791 RSVLVNSHLVCKVARLG-----------HSPQGSSSLLRWAAPEVITHGKYTTSSDVWSFGILMW 844

  Fly   937 EVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDN 1001
            |||||||||||:.|:|:|:.:||:.:|||.|..||..|:.||||.|||.|..||.|..:|:..|.
  Rat   845 EVMSYGERPYWDMSDQEVLNAIEQEFRLPPPPGCPTGLHLLMLDTWQKDRARRPHFDQLVAAFDK 909

  Fly  1002 LARQPQSLLTTRPSPESDGNHILDGQRGQNIFI-----------STDLWLEHIKMSRYCHHFKEA 1055
            :.|:|.:|       :::|:   .|.|.....:           |...||..|.:..|..:|.:.
  Rat   910 MIRKPDTL-------QAEGS---SGDRPSQALLNPVALDFPCLDSPQAWLSAIGLECYQDNFSKF 964

  Fly  1056 NLINAQQISRLTAQQLSDMGITLVGHQKKILHQARQL 1092
            .|.....:::|:.:.|..:||||.|||||:||..:.|
  Rat   965 GLSTFSDVAQLSLEDLPGLGITLAGHQKKLLHNIQLL 1001

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 60/200 (30%)
FN3 387..476 CDD:238020 20/104 (19%)
FN3 536..623 CDD:238020 20/86 (23%)
EphA2_TM 644..736 CDD:291255 25/93 (27%)
PTKc_EphR 736..1002 CDD:270629 131/265 (49%)
Pkinase_Tyr 741..999 CDD:285015 128/257 (50%)
SAM_1 1033..1092 CDD:278937 20/69 (29%)
SAM 1039..1092 CDD:197735 19/52 (37%)
Ephb6NP_001101327.1 EphR_LBD_B6 33..225 CDD:198443 60/200 (30%)
TNFRSF 294..361 CDD:276900 25/66 (38%)
CRD2 311..342 CDD:276900 11/30 (37%)
FN3 364..463 CDD:238020 23/116 (20%)
FN3 480..571 CDD:238020 23/117 (20%)
EphA2_TM 604..657 CDD:291255 22/81 (27%)
PKc_like 657..911 CDD:304357 131/266 (49%)
Pkinase_Tyr 662..907 CDD:285015 128/257 (50%)
SAM_EPH-B6 937..1005 CDD:188954 21/65 (32%)
SAM 938..1004 CDD:197735 21/64 (33%)
PDZ-binding. /evidence=ECO:0000255 1011..1013
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 121 1.000 Domainoid score I5543
eggNOG 1 0.900 - - E2759_KOG0196
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 763 1.000 Inparanoid score I521
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D397694at33208
OrthoFinder 1 1.000 - - FOG0000086
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100189
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X82
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
109.770

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