DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eph and tek

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:XP_009299388.1 Gene:tek / 30747 ZFINID:ZDB-GENE-990415-56 Length:1117 Species:Danio rerio


Alignment Length:675 Identity:171/675 - (25%)
Similarity:287/675 - (42%) Gaps:154/675 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   387 PAA---------PTNLTLLFVDQTSAIISWS-APAKNESFSSETNSKIYHSDIVYKIKCNICSPN 441
            |||         |..:.|..|.||:.::||. |||:..              ..|::.|      
Zfish   529 PAATFSTQVLELPVGVKLSAVSQTALLLSWDIAPAEQH--------------CTYEVSC------ 573

  Fly   442 VVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFK-RHSNESSLVAVSDIVFSNTSL 505
                            |....|.|..|.|:.:.:|..|:::.| ||..:.::.:...:..::.|.
Zfish   574 ----------------LQAGAPGTLRTFQLPSNSSAMHLSDLKPRHKYQCTVRSSCGVGQNHPSA 622

  Fly   506 LNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEW---DKPVQSDFPLEFYEV- 566
            ....|...|:....|               |:.|..|::..|.|.|   :....|...:.|.:| 
Zfish   623 SAWTLSDPELPPPPA---------------NISIWNISDTSAVLTWAVAEGESVSRAVIRFQQVE 672

  Fly   567 --RWFPKVELDAINKSALNTKE--TKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTL--- 624
              ::..:|||      .:.|::  .:..::||..||.|..|:....|.|..:.|..:...||   
Zfish   673 QAQYRQQVEL------PVQTQQLHMRFQLLGLRPNTGYQLQLWTVNNMGESAESPPVSLMTLPQQ 731

  Fly   625 --QSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASN 687
              .::.:.:...:....:..|.:|....|:.|.|.                    |.|..:....
Zfish   732 ESSALFAAHGHLLLYAILGSAGMTCCTVLLAFCIV--------------------LQLKRNTLQR 776

  Fly   688 EVNS-MDTTPIVKKLHLNVTTPLFGN----SRSYVDPHTYEDPNQAIREFAREIDANYITIEAII 747
            .::| :...|.|   |.:...|....    |||.|.|               .:..:.|..:.::
Zfish   777 RIHSILREEPAV---HFSSAPPPHRRSAVVSRSLVFP---------------ALQWSDIQFQDVL 823

  Fly   748 GGGEFGDVCRGRLKIPPNFVQD---IDVAIKTLKPGSSEKARCDFLTEASIMGQF-DHPNVIYLQ 808
            |.|.||.|.:.|::      :|   :|.|:|.:|..:|:....||..|..::.:. .|.|:|:|.
Zfish   824 GEGNFGQVLKARIR------KDGLRMDAAVKRMKDYASQDDHRDFAGELEVLCRLGPHKNIIHLL 882

  Fly   809 GVVTRSNPVMIITEYMENGSLDTFLRVN-----DGKF-------QTL---QLIVMLRGIASGMSY 858
            |.......:.:..|:..:|:|..|||.:     |..|       .||   ||:.....:|.||||
Zfish   883 GACEHRGYLYLAIEFAPHGNLLDFLRKSRVLETDPAFAIAHRTASTLSSQQLLAFSADVARGMSY 947

  Fly   859 LSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRG-GKIPVRWTAPEAIAFRKF 922
            ||...::|||||||||||....:.|||||||||    ..:.|..:. |::||||.|.|::.:..:
Zfish   948 LSQKQFIHRDLAARNVLVGENFVAKIADFGLSR----GQEVYVKKTMGRLPVRWMAIESLNYSVY 1008

  Fly   923 TSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRT 987
            |:.||||||||:||||:|.|..||...:..::.:.:..|:||..|::|.:.:|:||..||:::..
Zfish  1009 TTNSDVWSYGVLLWEVVSLGGTPYCGMTCAELYEKLPLGFRLEKPLNCDDEVYELMQQCWREKPF 1073

  Fly   988 HRPTFASIVSTLDNLARQPQSLLTT 1012
            .||:|:.|:.:|..:..:.::.:.|
Zfish  1074 ERPSFSQILLSLGRMLEERKTYVNT 1098

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439
FN3 387..476 CDD:238020 20/98 (20%)
FN3 536..623 CDD:238020 22/94 (23%)
EphA2_TM 644..736 CDD:291255 16/96 (17%)
PTKc_EphR 736..1002 CDD:270629 100/285 (35%)
Pkinase_Tyr 741..999 CDD:285015 99/277 (36%)
SAM_1 1033..1092 CDD:278937
SAM 1039..1092 CDD:197735
tekXP_009299388.1 Ig_Tie2_1 25..121 CDD:287411
EGF_2 224..255 CDD:285248
IG_like 354..439 CDD:214653
fn3 541..621 CDD:278470 22/115 (19%)
FN3 633..717 CDD:214495 22/104 (21%)
PTKc_Tie2 809..1111 CDD:133219 102/315 (32%)
STYKc 817..1085 CDD:214568 99/277 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.