DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eph and tek

DIOPT Version :10

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:XP_009299388.1 Gene:tek / 30747 ZFINID:ZDB-GENE-990415-56 Length:1117 Species:Danio rerio


Alignment Length:675 Identity:171/675 - (25%)
Similarity:287/675 - (42%) Gaps:154/675 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   387 PAA---------PTNLTLLFVDQTSAIISWS-APAKNESFSSETNSKIYHSDIVYKIKCNICSPN 441
            |||         |..:.|..|.||:.::||. |||:..              ..|::.|      
Zfish   529 PAATFSTQVLELPVGVKLSAVSQTALLLSWDIAPAEQH--------------CTYEVSC------ 573

  Fly   442 VVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFK-RHSNESSLVAVSDIVFSNTSL 505
                            |....|.|..|.|:.:.:|..|:::.| ||..:.::.:...:..::.|.
Zfish   574 ----------------LQAGAPGTLRTFQLPSNSSAMHLSDLKPRHKYQCTVRSSCGVGQNHPSA 622

  Fly   506 LNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEW---DKPVQSDFPLEFYEV- 566
            ....|...|:....|               |:.|..|::..|.|.|   :....|...:.|.:| 
Zfish   623 SAWTLSDPELPPPPA---------------NISIWNISDTSAVLTWAVAEGESVSRAVIRFQQVE 672

  Fly   567 --RWFPKVELDAINKSALNTKE--TKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTL--- 624
              ::..:|||      .:.|::  .:..::||..||.|..|:....|.|..:.|..:...||   
Zfish   673 QAQYRQQVEL------PVQTQQLHMRFQLLGLRPNTGYQLQLWTVNNMGESAESPPVSLMTLPQQ 731

  Fly   625 --QSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASN 687
              .::.:.:...:....:..|.:|....|:.|.|.                    |.|..:....
Zfish   732 ESSALFAAHGHLLLYAILGSAGMTCCTVLLAFCIV--------------------LQLKRNTLQR 776

  Fly   688 EVNS-MDTTPIVKKLHLNVTTPLFGN----SRSYVDPHTYEDPNQAIREFAREIDANYITIEAII 747
            .::| :...|.|   |.:...|....    |||.|.|               .:..:.|..:.::
Zfish   777 RIHSILREEPAV---HFSSAPPPHRRSAVVSRSLVFP---------------ALQWSDIQFQDVL 823

  Fly   748 GGGEFGDVCRGRLKIPPNFVQD---IDVAIKTLKPGSSEKARCDFLTEASIMGQF-DHPNVIYLQ 808
            |.|.||.|.:.|::      :|   :|.|:|.:|..:|:....||..|..::.:. .|.|:|:|.
Zfish   824 GEGNFGQVLKARIR------KDGLRMDAAVKRMKDYASQDDHRDFAGELEVLCRLGPHKNIIHLL 882

  Fly   809 GVVTRSNPVMIITEYMENGSLDTFLRVN-----DGKF-------QTL---QLIVMLRGIASGMSY 858
            |.......:.:..|:..:|:|..|||.:     |..|       .||   ||:.....:|.||||
Zfish   883 GACEHRGYLYLAIEFAPHGNLLDFLRKSRVLETDPAFAIAHRTASTLSSQQLLAFSADVARGMSY 947

  Fly   859 LSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRG-GKIPVRWTAPEAIAFRKF 922
            ||...::|||||||||||....:.|||||||||    ..:.|..:. |::||||.|.|::.:..:
Zfish   948 LSQKQFIHRDLAARNVLVGENFVAKIADFGLSR----GQEVYVKKTMGRLPVRWMAIESLNYSVY 1008

  Fly   923 TSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRT 987
            |:.||||||||:||||:|.|..||...:..::.:.:..|:||..|::|.:.:|:||..||:::..
Zfish  1009 TTNSDVWSYGVLLWEVVSLGGTPYCGMTCAELYEKLPLGFRLEKPLNCDDEVYELMQQCWREKPF 1073

  Fly   988 HRPTFASIVSTLDNLARQPQSLLTT 1012
            .||:|:.|:.:|..:..:.::.:.|
Zfish  1074 ERPSFSQILLSLGRMLEERKTYVNT 1098

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439
FN3 387..476 CDD:238020 20/98 (20%)
FN3 536..623 CDD:238020 22/94 (23%)
EphA2_TM 640..738 CDD:464211 17/102 (17%)
PTKc_EphR 736..1002 CDD:270629 100/285 (35%)
SAM_1 1029..1092 CDD:425739
tekXP_009299388.1 Ig_Tie2_1 25..121 CDD:463089
EGF_CA <231..255 CDD:238011
Ig 348..437 CDD:472250
Ig strand B 364..368 CDD:409353
Ig strand C 380..384 CDD:409353
Ig strand E 405..409 CDD:409353
Ig strand F 419..424 CDD:409353
Ig strand G 432..435 CDD:409353
fn3 541..621 CDD:394996 22/115 (19%)
FN3 633..717 CDD:214495 22/104 (21%)
PTKc_Tie2 809..1111 CDD:133219 102/315 (32%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.