DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eph and epha2a

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:NP_571490.1 Gene:epha2a / 30689 ZFINID:ZDB-GENE-990415-63 Length:984 Species:Danio rerio


Alignment Length:1072 Identity:406/1072 - (37%)
Similarity:568/1072 - (52%) Gaps:153/1072 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 RMSLLRTILLIIISIHFKLAHADQVVLLDTTREAT-LEWTRYPYGPQAQTPGWVEESFTDFVKGI 124
            |::.:..:.|.:.:..|....:.:.||||.....: |.|..:|     :..||  |.....|.|.
Zfish     4 RLTRVSFLFLYLFANVFTGIQSKEHVLLDMKAAGSELGWLTWP-----KEEGW--EVVQTVVNGS 61

  Fly   125 NWRSYVVCDVAYH-NVNNWLWSPFID-RGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYE 187
            ...:|.||:||.. ..:|||.:.||. |...:|:.:|:.|.:||||.|.|::.||:|||.|...|
Zfish    62 LLYTYSVCNVASDTEQDNWLRTTFIQRRPDVSRMSVELSFIVRDCSTFGGSSPSCRETFGLFLGE 126

  Fly   188 FDA--ATREPPPWQTDSYRLIARIA-------AGEGRFNQNSDVDINTEVKSI-AVNKKGVYFAF 242
            .|:  .|.    ::...:|.:|.:|       .|.||    :|:.:|.|.:|| .::::|.|.||
Zfish   127 TDSDVGTN----FRKSQFRKVATVAPDEVTADRGRGR----ADLRVNVEKRSIGTLSRRGFYLAF 183

  Fly   243 RDQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPY--ETPTYLCK 305
            :|.|.|:::|.::|:|.||||...:.|.|.|     ::.:..:..||||.:|...  ..|...|.
Zfish   184 QDLGGCVALLGLRVFYTTCPATMRSLAAFPE-----QVALGAEVEGTCVKDAVVLGEAAPRMYCT 243

  Fly   306 GDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKSPEVTK-CTPCPPNSNASKTGSPFCKCAS 369
            .:|.|.:..|.|.|:|||:.  ...:|..|..|.:||.:.:: |..||.|:..|..|:..|.|..
Zfish   244 AEGDWVVPVGQCVCRAGYQA--VGDSCKACEPGFYKSTDSSQPCEVCPENTQRSGRGALLCPCME 306

  Fly   370 GFYRHPNDGRHMPCYSPPAAPTNLTLL-FVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI 433
            ||||.|.|....||.|.|:.|.:|... .:...|..:.|..||       :|..:   ||:.|.:
Zfish   307 GFYRAPTDPISAPCSSLPSPPRDLVYTPLLTAGSLQLLWRPPA-------DTGGR---SDVTYSV 361

  Fly   434 K--------CNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNES 490
            .        |.:|...|.:.|:.......::.::.|||...||..:.|.|.||   :|.|...::
Zfish   362 ACERCEGGLCTLCGGRVRFEPAQTALRAPEVVVSELEPHVNYTFTVEAQNGVS---QFSRKRAKA 423

  Fly   491 SLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEW--DK 553
            |:..|                          :.||..    ..|..||:...|.....|.|  |.
Zfish   424 SITTV--------------------------LHFTDG----PRVLYLRVEDRTTSSLTLSWAVDH 458

  Fly   554 PVQSDFPLEFYEVRWFPKV---ELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGF-GS 614
            .||:. |...||:.:..|.   |||....:.|..::....|..||..|:|.|:|...|..|. .|
Zfish   459 HVQNQ-PSPRYELMYRKKEDPGELDVTTYTVLVLEKNSVPINDLLPGTKYVFRVHTLTAEGHPSS 522

  Fly   615 YSNMIYAQTLQSVGSVYDDSVQIRFIAGAIV-TGVLFLVIFIIATVYFMR----SKHQDDLDKKS 674
            :|..:..:||....|...:|..:  :.|||. .||:.|::.:|..::..|    .:.:.|.|..|
Zfish   523 HSAELEFETLPLAESRTQNSSMV--VMGAIAGGGVMLLIVVVILLLHKRRLNSHVRRRVDGDYFS 585

  Fly   675 TNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDAN 739
            .....|||                               ::|:||||||||..||.:||.||...
Zfish   586 CPEKLLPL-------------------------------KTYIDPHTYEDPCAAILKFASEIHPG 619

  Fly   740 YITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNV 804
            :||.:.:||.||||:|.||.||:|..  .::.|||||||||.:||.|.|||:||||||||.|.|:
Zfish   620 HITKQKVIGAGEFGEVFRGSLKMPGR--SEVAVAIKTLKPGYTEKQRQDFLSEASIMGQFSHKNI 682

  Fly   805 IYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDL 869
            |.|:||||:....||||||||||:||.:||.:||.|.:.||:.||.|||:||.||||||||||||
Zfish   683 IRLEGVVTKFKDAMIITEYMENGALDQYLRDHDGDFSSYQLVGMLNGIAAGMKYLSDMNYVHRDL 747

  Fly   870 AARNVLVNAQLICKIADFGLSREIENASD-AYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGV 933
            ||||||||:.|.||::||||||.:|:..: .|||.|||||:|||||||||:|||||||||||:|:
Zfish   748 AARNVLVNSNLECKVSDFGLSRVLEDFPEGTYTTTGGKIPIRWTAPEAIAYRKFTSASDVWSFGI 812

  Fly   934 VLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVST 998
            |:|||||:||||||:.|||:|:|||..||||||||.||.|:.||||.||.:.|:.||.|..||:.
Zfish   813 VMWEVMSFGERPYWDMSNQEVMKSINDGYRLPAPMGCPSAVNQLMLQCWMQDRSTRPRFVDIVNL 877

  Fly   999 LDNLARQPQSL-----LTTRPS---PESDGNHILDGQRGQNIFISTDLWLEHIKMSRYCHHFKEA 1055
            |:.|.|.|:||     :..|.|   |.:.|   .||..    |.|.|.|||.|||::|...|..|
Zfish   878 LEKLLRNPESLTSIASIDPRVSIRLPSTSG---CDGAP----FRSVDEWLESIKMAQYRETFALA 935

  Fly  1056 NLINAQQISRLTAQQLSDMGITLVGHQKKILH 1087
            .:.:..|:.||..:.:.::|:.|.||||:|.:
Zfish   936 GIKSIDQVLRLKIEDIGNIGVRLAGHQKRIAY 967

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 62/187 (33%)
FN3 387..476 CDD:238020 21/97 (22%)
FN3 536..623 CDD:238020 27/92 (29%)
EphA2_TM 644..736 CDD:291255 25/96 (26%)
PTKc_EphR 736..1002 CDD:270629 174/266 (65%)
Pkinase_Tyr 741..999 CDD:285015 172/258 (67%)
SAM_1 1033..1092 CDD:278937 22/55 (40%)
SAM 1039..1092 CDD:197735 19/49 (39%)
epha2aNP_571490.1 EphR_LBD_A2 27..202 CDD:198448 62/189 (33%)
FN3 324..417 CDD:238020 24/105 (23%)
FN3 440..531 CDD:238020 27/91 (30%)
EphA2_TM 544..616 CDD:291255 27/104 (26%)
PTKc_EphR_A2 615..882 CDD:133194 175/268 (65%)
Pkinase_Tyr 621..878 CDD:285015 172/258 (67%)
SAM_EPH-A2 909..978 CDD:188942 24/63 (38%)
SAM 909..975 CDD:197735 24/63 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 396 1.000 Domainoid score I723
eggNOG 1 0.900 - - E2759_KOG0196
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 753 1.000 Inparanoid score I540
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D397694at33208
OrthoFinder 1 1.000 - - FOG0000086
OrthoInspector 1 1.000 - - otm24639
orthoMCL 1 0.900 - - OOG6_100189
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X82
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1110.870

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