DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eph and ephb4a

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:NP_571489.1 Gene:ephb4a / 30688 ZFINID:ZDB-GENE-990415-62 Length:987 Species:Danio rerio


Alignment Length:1075 Identity:423/1075 - (39%)
Similarity:593/1075 - (55%) Gaps:166/1075 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 IISIHFKLAH-ADQVVLLDT-TREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCDV 134
            :|.:.|.|.. |::.||::| |..:.|:||.:    ....|.|.|.|..| .:..:.|:|.:|. 
Zfish    13 VILLEFLLGSVAEEEVLMNTKTETSDLKWTTH----SRSKPEWEEVSGLD-EENNSVRTYQICQ- 71

  Fly   135 AYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDA--ATREPPP 197
            |..:.::.:.|..|:|..|:::|:|:.||:.:||....:..||||||:|.:|:.|.  ||...|.
Zfish    72 ADGSSSHCVRSKLIERRGASQVYVELFFTMVECSSRNTHHRSCKETFNLYYYQSDTDDATATHPA 136

  Fly   198 WQTDSYRLIARIAA-------GEGRFNQNSDVDINTEVKSI---AVNKKGVYFAFRDQGACISVL 252
            |..:.|..:..:||       ||.:.|          ||::   .::|:|.|.||:.||||:::|
Zfish   137 WMENPYTKVDTVAADFLLRKGGEKKVN----------VKTLRLGPLSKRGFYLAFQAQGACMALL 191

  Fly   253 AVKVYYITCPAVTENFAHFNET-PTGREITIIEKQNGTCVDN-AEPYET---PTYLCKGDGKWTI 312
            :|:|::..|||:|.:.:.|.|| |.    :::::..|.||.| |:|..:   |...|..||:|..
Zfish   192 SVRVFFKKCPALTRSLSVFPETVPR----SLVQEAVGQCVANAAQPGPSPRPPKMFCGEDGQWVD 252

  Fly   313 L-TGGCRCKAGYEPNYTNKTCTECPLGTFKSPEVT-KCTPCPPNSNASKTGSPFCKCASGFYRHP 375
            . |..|.|..|:|.::....|..||:|.||....| .|:.||.||...:|||..|.|.|||||..
Zfish   253 QPTTTCTCLPGFEASHGELECRACPVGLFKMGSGTGPCSVCPENSQTGETGSAACVCRSGFYRAL 317

  Fly   376 NDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIK------ 434
            :|....||..||::|.: .:..|:.||..:.||.|..:..          .||:.|.::      
Zfish   318 SDSADTPCTRPPSSPRS-PVPQVNDTSLTLEWSEPLDSGG----------RSDLSYSVECRMCST 371

  Fly   435 ----CNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAV 495
                |.:||..|.|.||.......::::..|.|.|||:..:.|:|.||      ..|.:......
Zfish   372 PGSPCTLCSDGVNYRPSQTGIQGRRVSIWGLRPHTTYSFTVMALNGVS------AQSQQGPAGET 430

  Fly   496 SDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFP 560
            .:|    |:..|:|                   ||:|   .||....|.....|.|:.|.||.:.
Zfish   431 INI----TTSPNVP-------------------VLVS---GLRKSTATESSLTLYWNTPTQSHYR 469

  Fly   561 LEFYEVRWFPKVELDAINKSA--LNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQT 623
            :..|::|:..| |..:...|.  :.:...:..:..|...|:|..|||.:|..|:||:...|..:|
Zfish   470 ILQYQIRYCEK-ERGSEENSCHYMESNNNEVVLSDLRRATQYEVQVRARTFAGYGSFGKAILFRT 533

  Fly   624 LQSVGSVYDDSVQIRFIAGAIVT-GVLFLVIFIIATVYFMRSKH---QDDLDKKSTNHLPLPLDY 684
            |..    .|||.....:.|.::. |:|.|:|.|.|.:|.:|.::   ..:|..|:..:       
Zfish   534 LPD----EDDSSSPLLVTGILIAMGMLLLIIVIGAAIYCIRKQNNYKDPELSDKNGQY------- 587

  Fly   685 ASNEVNSMDTTPIVKKLHLNVTTPLFGNS-RSYVDPHTYEDPNQAIREFAREIDANYITIEAIIG 748
                                    |.|.. :.|:||.||||||:|:||||:|||.:.:.||.:||
Zfish   588 ------------------------LMGQGVKVYIDPFTYEDPNEAVREFAKEIDVSCVKIEEVIG 628

  Fly   749 GGEFGDVCRGRLKIP---PNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGV 810
            .||||:||||||:||   .|:     |||||||.|.::|.|.|||.||||||||.|||:|:|:|:
Zfish   629 AGEFGEVCRGRLRIPGKKENY-----VAIKTLKGGYTDKQRRDFLAEASIMGQFQHPNIIHLEGI 688

  Fly   811 VTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVL 875
            :|.|.||||:||:||||:||:|||:|||:|..:||:.|||||||||.|||:|:||||||||||:|
Zfish   689 ITASCPVMILTEFMENGALDSFLRLNDGQFTPIQLVGMLRGIASGMKYLSEMSYVHRDLAARNIL 753

  Fly   876 VNAQLICKIADFGLSREI-ENASD-AYTTR-GGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWE 937
            ||:.|:||::||||||.: ||:|| .||:. |||||:||||||||||||||.||||||||:|:||
Zfish   754 VNSNLVCKVSDFGLSRFLQENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTCASDVWSYGIVMWE 818

  Fly   938 VMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNL 1002
            |||:||||||:.||||||.:||:.||||.|.||...|:|||||||||:||.||.||:|||.||.|
Zfish   819 VMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCSTYLHQLMLDCWQKERTARPRFANIVSALDKL 883

  Fly  1003 ARQPQSLLTTRPSPESDGNHILD----------GQRGQNIFISTDLWLEHIKMSRYCHHFKEANL 1057
            .|.|.||..|........:.:||          |..|.        ||..|||.||...|.:|..
Zfish   884 IRNPASLKITAQEGAGPSHPLLDQRSPLTPSSCGTVGD--------WLRAIKMERYEETFLQAGY 940

  Fly  1058 INAQQISRLTAQQLSDMGITLVGHQKKILHQARQL 1092
            .:.|.::.:..:.|..:||||.|||||||.....|
Zfish   941 TSMQLVTHINTEDLLRLGITLAGHQKKILSSIEAL 975

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 59/187 (32%)
FN3 387..476 CDD:238020 24/98 (24%)
FN3 536..623 CDD:238020 24/88 (27%)
EphA2_TM 644..736 CDD:291255 26/96 (27%)
PTKc_EphR 736..1002 CDD:270629 185/271 (68%)
Pkinase_Tyr 741..999 CDD:285015 181/263 (69%)
SAM_1 1033..1092 CDD:278937 22/58 (38%)
SAM 1039..1092 CDD:197735 22/52 (42%)
ephb4aNP_571489.1 EphR_LBD 26..199 CDD:383093 59/188 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 319..340 6/21 (29%)
FN3 339..435 CDD:238020 27/115 (23%)
FN3 440..533 CDD:238020 28/115 (24%)
EphA2_TM 551..616 CDD:373140 26/95 (27%)
PTKc_EphR_B 616..884 CDD:173638 185/272 (68%)
SAM_EPH-B4 914..980 CDD:188953 25/70 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 396 1.000 Domainoid score I723
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 753 1.000 Inparanoid score I540
OMA 1 1.010 - - QHG45908
OrthoDB 1 1.010 - - D397694at33208
OrthoFinder 1 1.000 - - FOG0000086
OrthoInspector 1 1.000 - - otm24639
orthoMCL 1 0.900 - - OOG6_100189
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X82
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
109.880

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