Protein Alignment Eph and ek1

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: NP_571170.1
• Gene: ek1 / 30311
• ZFINID: ZDB-GENE-990415-58
• Length: 981
• Species: Danio rerio
• Alignment Length: 1045
• Identity: 431/1045 - (41%)
• Similarity: 590/1045 - (56%)
• Gaps: 148/1045 - (14%)

  Fly    83 DQVVLLDT-TREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCDVAYHNVNNWLWSP 146
            ::|.|||: :....|.|..||      :.||.|.|..| .:.|..|:|.||:|...|.||||.:.
Zfish    28 NEVTLLDSMSAPGDLGWEAYP------SEGWEEISVMD-ERNIPMRTYQVCNVMEANQNNWLRTG 85

  Fly   147 FIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAATREPPPWQTDS-YRLIARIA 210
            .|.|..|.|:|:||:||:|||:..||...:|||||::.::|.:.|...|.....:| |..|..||
Zfish    86 LIQREGAQRVYVEIKFTLRDCNSLPGVPGTCKETFNVYYHESNNAVAAPLRHIRESQYIKIDTIA 150

  Fly   211 AGEGRFNQNSDVD----INTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAH 270
            |.|. |.|....|    :||||:.|: ::|:|:|.||:|.||||::::|:|:|..||....|.|.
Zfish   151 ADES-FTQTDVGDRVMKLNTEVRDISGLSKRGLYLAFQDLGACIALVSVRVFYKRCPLAVLNLAR 214

  Fly   271 FNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCTEC 335
            |.:|.||.:..::|.: ||||::||..|.|...|..||.|.:..|.|.|:.|:|.  .:..|..|
Zfish   215 FPDTVTGGDSALVEVR-GTCVEDAEELEGPRMFCSADGGWLVPIGRCVCRPGFEE--VDGHCQPC 276

  Fly   336 PLGTFKSPEV-TKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVD 399
            ..|.:|:..: ..|..|||:|.:.:..:..|.|..||||..:|.|.|.|..||:||.| .:..|:
Zfish   277 RSGFYKASAMDAYCVKCPPHSYSHQDKASECVCERGFYRAESDPRSMACTRPPSAPGN-PISMVN 340

  Fly   400 QTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICS-------------PNVVYNPSTDTF 451
            :|:..:.||.|..:..          ..|:.|.:.|..||             ....:||.....
Zfish   341 ETAVTLEWSPPRDSGG----------RGDVSYSVHCRKCSGETGASERCVPCGSGAHFNPRQFGL 395

  Fly   452 NETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVK 516
            ...::.:|.|:|.|.||..:.|:|.||.::...|     .||:|:                  |.
Zfish   396 THPRVLVTELQPHTNYTFSVEALNGVSDLSPSPR-----QLVSVN------------------VT 437

  Fly   517 TGQAEIVFTTESVLLSTVFNLRILAITNKDAD---LEWDKPVQSDFPLEFYEVRWFPKVELDAIN 578
            |.|      |.||:|.          ..|..|   |.|..|...|..:..|||.::.|.:.|. |
Zfish   438 TSQ------TVSVILK----------ERKGTDSVTLAWQGPEPVDGTVVEYEVTYYEKNQQDQ-N 485

  Fly   579 KSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQT----LQSVGSVYDDSVQIRF 639
            .:.|.||.....:.||...|.|.|:||.:|:.|:|:|...|..:|    :.:||.....::....
Zfish   486 YTVLKTKSNSMTVDGLKPGTTYIFRVRARTDGGYGNYKGEIELETSHEDMLAVGDPNQQTILAIS 550

  Fly   640 IAGAIVTGVLFLVIFIIA--TVYFMRSKHQDDLDKKSTNH--LPLPLDYASNEVNSMDTTPIVKK 700
            :||..|..||.:..||::  ...::::|...:.:|....|  :.||
Zfish   551 VAGGAVLLVLLVACFIVSGRRCGYIKAKQDPEEEKMQFQHGRVKLP------------------- 596

  Fly   701 LHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPN 765
                       .:|:|:.||||||||||:|:||:||:.:.|.||.:||.||||:||.|||::|..
Zfish   597 -----------ETRTYIHPHTYEDPNQAVRDFAKEIEVSNIRIERVIGAGEFGEVCSGRLRLPSK 650

  Fly   766 FVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLD 830
              ::|.||||:||.|.||..|.|||:||||||||||||:|.|:|||||..||||:||||||||||
Zfish   651 --REIQVAIKSLKAGYSEHQRRDFLSEASIMGQFDHPNIIRLEGVVTRCKPVMIVTEYMENGSLD 713

  Fly   831 TFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIEN 895
            |||:.:||:|..:||:.||||||:||.|||:||||||||||||:|||..|:||::||||||.:|:
Zfish   714 TFLKKHDGQFTVIQLLGMLRGIAAGMQYLSEMNYVHRDLAARNILVNRNLVCKVSDFGLSRVLED 778

  Fly   896 ASD-AYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIE 959
            ..: ||||||||||:||||||||.:|||||||||||||:|:|||:||||||||..|||||||:::
Zfish   779 DPEAAYTTRGGKIPIRWTAPEAITYRKFTSASDVWSYGIVMWEVISYGERPYWEMSNQDVIKAVD 843

  Fly   960 KGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPS--------P 1016
            :|||||||||||..|:|||||||:|.|:.||.|..||:|||.|.|.|.||.....|        |
Zfish   844 EGYRLPAPMDCPVVLHQLMLDCWEKNRSDRPKFGQIVNTLDRLIRNPSSLKQLANSAVWEDPVTP 908

  Fly  1017 ESDGNHILDGQRGQNIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGH 1081
            |:..|.:.|             ||:.|||.:|..||..|..:....:..:::.:|..||:.|.||
Zfish   909 EAAVNTVED-------------WLDLIKMGQYKEHFSSAGYVTLDSVLYVSSSELDKMGVELAGH 960

  Fly  1082 QKKIL 1086
            |||||
Zfish   961 QKKIL 965

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	74/181 (41%)
		FN3	387..476	CDD:238020	23/101 (23%)
		FN3	536..623	CDD:238020	27/89 (30%)
		EphA2_TM	640..738	CDD:464211	29/101 (29%)
		PTKc_EphR	736..1002	CDD:270629	186/266 (70%)
		SAM_1	1029..1092	CDD:425739	20/58 (34%)
ek1	NP_571170.1	EphR_LBD_A	29..204	CDD:198441	74/182 (41%)
		FN3	<326..>563	CDD:442628	73/287 (25%)
		fn3	451..522	CDD:394996	24/71 (34%)
		EphA2_TM	547..623	CDD:464211	29/105 (28%)
		PTKc_EphR_A	621..887	CDD:270651	186/267 (70%)
		SAM_EPH-R	911..971	CDD:188887	22/68 (32%)
		PDZ-binding. /evidence=ECO:0000255	979..981