Protein Alignment Eph and Epha10

DIOPT Version :9

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: XP_038965557.1
• Gene: Epha10 / 298528
• RGDID: 1562679
• Length: 1061
• Species: Rattus norvegicus
• Alignment Length: 1115
• Identity: 358/1115 - (32%)
• Similarity: 530/1115 - (47%)
• Gaps: 200/1115 - (17%)

  Fly    82 ADQVVLLDT-TREATLEWTRYPYGPQAQTPGWVEESFTDFVKGIN-----WRSYVVCDVAYHNVN 140
            |::|.|||: ..:|.|.||..|      :.||.|      :.|::     .|:|.||:|...|.:
  Rat    33 AEEVTLLDSKASQAELGWTALP------STGWEE------ISGVDEHDRPIRTYQVCNVLEPNQD 85

  Fly   141 NWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDA-ATREPPPWQTDSYR 204
            |||.:.:|.||...|:::|:|||:||||..||...:|||||:..:.|.:| ..|..|....:..|
  Rat    86 NWLQTGWISRGRGQRIFVELQFTLRDCSSIPGATGTCKETFNAYYLETEADLGRGHPHLGGNRPR 150

  Fly   205 LIARIAAGEGRFNQNS----DVDINTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCPAV 264
            .|..|||.|. |.|..    .:.:||||:.|. ::::|.:.||:|.|||:::::|:|||..|.|.
  Rat   151 KIDTIAADES-FTQGDLGERKMKLNTEVREIGPLSRQGFHLAFQDVGACVALVSVRVYYKQCRAT 214

  Fly   265 TENFAHFNETPTGREITIIEKQNGTCV--DNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNY 327
            ....|.|..|......:.:.:..||||  ...||...|...|..||:|.:..|.|.|.||::..
  Rat   215 VRGLAAFPATAAESAFSTLVEVAGTCVAHSEGEPSSPPRMHCGADGEWLVPVGRCSCSAGFQER- 278

  Fly   328 TNKTCTECPLGTFK-SPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPT 391
             ...|..||.|.:| ||....|:|||.:|.|.:..|.||.|...:.|.|.|.....|..||:||.
  Rat   279 -GDICEACPPGFYKVSPRRPLCSPCPEHSLALENASTFCVCQDTYARSPTDPPSASCTRPPSAPR 342

  Fly   392 NLTLLFVDQTSAI-ISWSAPAKNESFSSETNSKIYHSDIVYKI------------KCNICSPNVV 443
            :|.........|: :.|..|..:..          .||:.|.:            .|..|.|.|.
  Rat   343 DLQYSLSRSPLALRLRWLPPEDSGG----------RSDVTYSLLCLRCGRDGPAGACQPCGPRVA 397

  Fly   444 YNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLL-- 506
            :.|......|...||.:|.|...|||::.|:|.|            |...|.:...::..::.
  Rat   398 FVPRQAGLRERAATLLHLRPGARYTVRVAALNGV------------SGPAAAAGATYAQVTVSTG 450

  Fly   507 -NIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPV---QSDFPLEFYEVR 567
             ..|.:.:|::..:.|    .:||.||                  |.:||   .|......||:|
  Rat   451 PGAPWEEDEIRRDRVE----PQSVSLS------------------WREPVPAGASGTNRTEYEIR 493

  Fly   568 WFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNN---GFGSYSNMIYAQTLQSV-- 627
            ::.|.:.:. ..|.:.|......:..|...|.|.||:|..:..   ...|:|..|..||...|
  Rat   494 YYEKGQSEQ-TYSTVKTGAPAVTVTNLKPATRYVFQIRAASPGPSWEAQSFSPSIEVQTPGEVAP 557

  Fly   628 GSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSM 692
            || .|.|..:      :||.|....:.::.:|..:.:..:...|.|.:.             |:.
  Rat   558 GS-RDQSPAV------VVTVVTISALLVLGSVMSVLAIWRRPCDGKGSG-------------NAH 602

  Fly   693 DTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCR 757
            |...:.  .|..|.|     .|:::||.:..||.||:..||:|:||..:|:|..:|.|.|||:|.
  Rat   603 DEEELY--FHFKVPT-----RRTFLDPQSCGDPLQAVHLFAKELDAKSVTLEKSLGAGRFGDLCC 660

  Fly   758 GRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITE 822
            |.|::|..  |::.||:.||:.|.|:..:..||.||..:|||||.:::.|:|||||.||:||:||
  Rat   661 GCLQLPGR--QELPVAVHTLREGCSDSQKLSFLAEALTLGQFDHSHIVRLEGVVTRGNPLMIVTE 723

  Fly   823 YMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADF 887
            ||..|:||.|||.::.:..|.||:.:|.|:||.|.|||:|.||||.||||.||:::.|||||:.|
  Rat   724 YMNLGALDDFLRHHEAELVTAQLMGLLPGLASAMKYLSEMGYVHRGLAARRVLLSSGLICKISGF 788

  Fly   888 GLSREIENASDAYTTR------------------------------------------------- 903
            |.... :.|...|||.
  Rat   789 GRGPR-DRAEAVYTTMVRSSLLWPHMLLLLSAIPTGPMVYILALPPSLPGLFPLVVPCLSQPGSF 852

  Fly   904 -----GGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYR 963
                 .|:.|..|.|||.:.|..|:|||||||:|:|:||||::||||||:.|.|||||::|.|:|
  Rat   853 LRCGGSGRSPALWAAPETLQFGHFSSASDVWSFGIVMWEVMAFGERPYWDMSGQDVIKAVEDGFR 917

  Fly   964 LPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQ-----SLLTTR-PSPESDGNH 1022
            ||.|.:||..|::|||:||||....||.|:.|.|.|..:.::|:     |....| |:|.:|
  Rat   918 LPPPRNCPSQLHRLMLECWQKDPGERPRFSQIHSILSKMGQEPEPSKCASTTCLRPPTPLAD--- 979

  Fly  1023 ILDGQRGQNIFI---STDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKK 1084
                 |..:.|.   |...|||.:.:.||..:|..|...:.:.::.:|||.|..:||:...|::.
  Rat   980 -----RAFSAFPSFGSVGAWLEALDLCRYKDNFSAAGYGSLEAVTEMTAQDLGSLGISSAEHREA 1039

  Fly  1085 ILHQARQLDT 1094
            :|.....|.|
  Rat  1040 LLSGISALQT 1049

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	69/186 (37%)
		FN3	387..476	CDD:238020	24/101 (24%)
		FN3	536..623	CDD:238020	19/92 (21%)
		EphA2_TM	644..736	CDD:291255	20/91 (22%)
		PTKc_EphR	736..1002	CDD:270629	137/319 (43%)
		Pkinase_Tyr	741..999	CDD:285015	134/311 (43%)
		SAM_1	1033..1092	CDD:278937	17/61 (28%)
		SAM	1039..1092	CDD:197735	15/52 (29%)
Epha10	XP_038965557.1	EphR_LBD	35..210	CDD:413445	69/187 (37%)
		fn3	339..431	CDD:394996	24/101 (24%)
		FN3	451..551	CDD:238020	26/122 (21%)
		EphA2_TM	568..641	CDD:405290	21/92 (23%)
		PKc_like	638..956	CDD:419665	138/320 (43%)
		SAM_EPH-A10	982..1051	CDD:188948	19/68 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5543
eggNOG	1	0.900	-	-		E2759_KOG0196
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D397694at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100189
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X82
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.820