DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eph and Epha6

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:XP_017453593.2 Gene:Epha6 / 29202 RGDID:1304614 Length:1130 Species:Rattus norvegicus


Alignment Length:1087 Identity:419/1087 - (38%)
Similarity:583/1087 - (53%) Gaps:172/1087 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 ADQVVLLDTTR-EATLEWTRYPYGPQAQTPGWVEESFTDF---VKGINWRSYVVCDVAYHNVNNW 142
            ::||||||||. ...|.|..||..      ||  ::.|:.   .:.|:  :|.||:|...|.|||
  Rat   126 SNQVVLLDTTTVMGELGWKTYPLN------GW--DAITEMDEHNRPIH--TYQVCNVMEPNQNNW 180

  Fly   143 LWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAA--TREPPPWQTDSYRL 205
            |.:.:|.|.:|.::|:|::||:|||:..|....:|||||:|.:.|.|.:  |:..|    ..|..
  Rat   181 LRTNWISRDAAQKIYVEMKFTLRDCNSIPWVLGTCKETFNLYYIESDESHGTKFKP----SQYIK 241

  Fly   206 IARIAAGEGRFNQ----NSDVDINTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCPAVT 265
            |..|||.|. |.|    :..:.:||||:.:. :.:||.|.||:|.||||::::|:|:|..||...
  Rat   242 IDTIAADES-FTQMDLGDRILKLNTEVREVGPIERKGFYLAFQDIGACIALVSVRVFYKKCPFTV 305

  Fly   266 ENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNK 330
            .|.|.|.:|....:.:.:.:..|:||.:||..:||...|..||.|.:..|.|.|..|||.  ...
  Rat   306 RNLAMFPDTIPRVDSSSLVEVRGSCVKSAEERDTPKLYCGADGDWLVPLGRCICTTGYEE--IEG 368

  Fly   331 TCTECPLGTFKS-PEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLT 394
            :|..|..|.:|: ...|||:.|||:|:.....:..|.|..|::|...|...|.|..||:||.|:.
  Rat   369 SCHACRPGFYKAFAGNTKCSKCPPHSSTFVEATSVCHCEKGYFRAEKDPPSMACTRPPSAPRNVA 433

  Fly   395 LLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI---KCNI-------CSPNVVYNP-ST 448
             ..:::|:.|:.||.|       |:|..:   .|:.|.:   ||.:       |...:.:.| .|
  Rat   434 -FNINETALILEWSPP-------SDTGGR---KDLTYSVICKKCGVDASQCEDCGAGLRFIPRPT 487

  Fly   449 DTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLN 513
            ...|.:.:.|..:..| .||.:|.|:|.||.:             ::|...|:            
  Rat   488 GLINNSVVVLDFVSHV-NYTFEIEAMNGVSEL-------------SISPKPFT------------ 526

  Fly   514 EVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAIN 578
                   .|..||:....|.:..:|....:.....|.|..|..|:..:..||::::.| |.:.:.
  Rat   527 -------AITVTTDQDAPSLIGMMRKDWASQNSLALSWQAPAFSNGAILDYEIKYYEK-EHEQLT 583

  Fly   579 KSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGA 643
            .|:..:|.....|.||...|.|.|.:|.:|..|:..||.....:|......:..:..||..||.|
  Rat   584 YSSTRSKAPSVIITGLKPATTYIFHIRVRTATGYSGYSQKFEFETGDETSDMAAEQGQILVIATA 648

  Fly   644 IVTGVLFLVI---FIIAT---VYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLH 702
            .|.|...|||   |.:.|   .:::::|.:.  ::|...||.          ||          |
  Rat   649 AVGGFTLLVILTLFFLITGRCQWYIKAKMKS--EEKRRTHLQ----------NS----------H 691

  Fly   703 LNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFV 767
            |.     |...::|:||.|||||:.|:.|||:|||.:.|.||.:||.||||:||.||||.|..  
  Rat   692 LR-----FPGIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGK-- 749

  Fly   768 QDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTR------------------- 813
            ::|.|||||||.|..::.|.|||.||||||||||||:|.|:||||:                   
  Rat   750 REIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAG 814

  Fly   814 -----------------------SNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASG 855
                                   ..||||:.|||||||||:|||.:||.|..:||:.||||||||
  Rat   815 FLNGIQAPHPVTAGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASG 879

  Fly   856 MSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASD-AYTTRGGKIPVRWTAPEAIAF 919
            |.|||||.||||||||||:|||:.|:||::||||||.:|:..: ||||.|||||:|||||||||:
  Rat   880 MKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTTGGKIPIRWTAPEAIAY 944

  Fly   920 RKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQK 984
            |||:||||.||||:|:||||||||||||..||||||.|||:||||||||.||.:|:||||.||||
  Rat   945 RKFSSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLPAPMGCPPSLHQLMLHCWQK 1009

  Fly   985 QRTHRPTFASIVSTLDNLARQPQSLLTTRPS----PESDGNHILDGQRGQNIFISTDLWLEHIKM 1045
            :|.|||.|..|||.||.|.|.|.:|.|....    |||.|:     .....:|::...||:.|||
  Rat  1010 ERNHRPKFTDIVSFLDKLIRNPSALHTLVEDILVMPESPGD-----VPEYPLFVTVGDWLDSIKM 1069

  Fly  1046 SRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKILHQARQL 1092
            .:|..:|..|.......|||::...:..:|:.|:|||::|:...:.|
  Rat  1070 GQYKSNFMAAGFTTFDLISRMSIDDIRRIGVILIGHQRRIVSSIQTL 1116

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 70/185 (38%)
FN3 387..476 CDD:238020 25/99 (25%)
FN3 536..623 CDD:238020 22/86 (26%)
EphA2_TM 644..736 CDD:291255 28/97 (29%)
PTKc_EphR 736..1002 CDD:270629 187/308 (61%)
Pkinase_Tyr 741..999 CDD:285015 183/300 (61%)
SAM_1 1033..1092 CDD:278937 18/58 (31%)
SAM 1039..1092 CDD:197735 17/52 (33%)
Epha6XP_017453593.2 EphR_LBD_A6 128..300 CDD:198452 71/186 (38%)
Ephrin_rec_like 368..406 CDD:400166 12/37 (32%)
fn3 427..521 CDD:394996 27/118 (23%)
FN3 549..628 CDD:238020 21/79 (27%)
EphA2_TM 644..722 CDD:405290 33/104 (32%)
PTKc_EphR_A 720..1028 CDD:270651 187/309 (61%)
SAM_EPH-A6 1055..1118 CDD:188946 19/62 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 121 1.000 Domainoid score I5543
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 763 1.000 Inparanoid score I521
OMA 1 1.010 - - QHG45908
OrthoDB 1 1.010 - - D397694at33208
OrthoFinder 1 1.000 - - FOG0000086
OrthoInspector 1 1.000 - - otm46382
orthoMCL 1 0.900 - - OOG6_100189
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X82
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.980

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