DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eph and EPHA6

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:XP_006713655.1 Gene:EPHA6 / 285220 HGNCID:19296 Length:1146 Species:Homo sapiens


Alignment Length:1105 Identity:417/1105 - (37%)
Similarity:583/1105 - (52%) Gaps:194/1105 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 DQVVLLDTTRE-ATLEWTRYPYGPQAQTPGWVEESFTDF---VKGINWRSYVVCDVAYHNVNNWL 143
            :||||||||.. ..|.|..||..      ||  ::.|:.   .:.|:  :|.||:|...|.||||
Human   127 NQVVLLDTTTVLGELGWKTYPLN------GW--DAITEMDEHNRPIH--TYQVCNVMEPNQNNWL 181

  Fly   144 WSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAATREPPPWQTDSYRLIAR 208
            .:.:|.|.:|.::|:|::||:|||:..|....:|||||:|.:.|.|.:  ....::.:.|..|..
Human   182 RTNWISRDAAQKIYVEMKFTLRDCNSIPWVLGTCKETFNLFYMESDES--HGIKFKPNQYTKIDT 244

  Fly   209 IAAGEGRFNQ----NSDVDINTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENF 268
            |||.|. |.|    :..:.:|||::.:. :.:||.|.||:|.||||::::|:|:|..||....|.
Human   245 IAADES-FTQMDLGDRILKLNTEIREVGPIERKGFYLAFQDIGACIALVSVRVFYKKCPFTVRNL 308

  Fly   269 AHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCT 333
            |.|.:|....:.:.:.:..|:||.:||..:||...|..||.|.:..|.|.|..|||.  ...:|.
Human   309 AMFPDTIPRVDSSSLVEVRGSCVKSAEERDTPKLYCGADGDWLVPLGRCICSTGYEE--IEGSCH 371

  Fly   334 ECPLGTFKS-PEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLF 397
            .|..|.:|: ...|||:.|||:|......:..|:|..|::|...|...|.|..||:||.|: :..
Human   372 ACRPGFYKAFAGNTKCSKCPPHSLTYMEATSVCQCEKGYFRAEKDPPSMACTRPPSAPRNV-VFN 435

  Fly   398 VDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI----------KCNICSPNVVYNP-STDTF 451
            :::|:.|:.||.|       |:|..:   .|:.|.:          :|..|...:.:.| .|...
Human   436 INETALILEWSPP-------SDTGGR---KDLTYSVICKKCGLDTSQCEDCGGGLRFIPRHTGLI 490

  Fly   452 NETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVK 516
            |.:.|.|..:..| .||.:|.|:|.||.::                  ||....           
Human   491 NNSVIVLDFVSHV-NYTFEIEAMNGVSELS------------------FSPKPF----------- 525

  Fly   517 TGQAEIVFTTESVLLSTVFNLRILAITNKD------ADLEWDKPVQSDFPLEFYEVRWFPKV--- 572
               ..|..||:....|      ::.:..||      ..|.|..|..|:..:..||::::.||   
Human   526 ---TAITVTTDQDAPS------LIGVVRKDWASQNSIALSWQAPAFSNGAILDYEIKYYEKVYPR 581

  Fly   573 ------------ELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQ 625
                        |.:.:..|:..:|.....|.||...|:|.|.:|.:|..|:..||.....:|..
Human   582 IAPAFWHYLRVEEHEQLTYSSTRSKAPSVIITGLKPATKYVFHIRVRTATGYSGYSQKFEFETGD 646

  Fly   626 SVGSVYDDSVQIRFIAGAIVTGVLFLVI---FIIAT---VYFMRSKHQDDLDKKSTNHLPLPLDY 684
            ....:..:..||..||.|.|.|...|||   |.:.|   .:::::|.:.  ::|..|||      
Human   647 ETSDMAAEQGQILVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKS--EEKRRNHL------ 703

  Fly   685 ASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGG 749
                          :..||.     |...::|:||.|||||:.|:.|||:|||.:.|.||.:||.
Human   704 --------------QNGHLR-----FPGIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGA 749

  Fly   750 GEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTR- 813
            ||||:||.||||.|..  ::|.|||||||.|..::.|.|||.||||||||||||:|.|:||||: 
Human   750 GEFGEVCSGRLKTPGK--REIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKR 812

  Fly   814 -----------------------------------------SNPVMIITEYMENGSLDTFLRVND 837
                                                     ..||||:.|||||||||:|||.:|
Human   813 SFPAIGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHD 877

  Fly   838 GKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASD-AYT 901
            |.|..:||:.|||||||||.|||||.||||||||||:|||:.|:||::||||||.:|:..: |||
Human   878 GHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYT 942

  Fly   902 TRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPA 966
            |.|||||:|||||||||:|||:||||.||||:|:||||||||||||..||||||.|||:||||||
Human   943 TTGGKIPIRWTAPEAIAYRKFSSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLPA 1007

  Fly   967 PMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPS----PESDGNHILDGQ 1027
            ||.||.:|:||||.||||:|.|||.|..|||.||.|.|.|.:|.|....    |||.|.     .
Human  1008 PMGCPASLHQLMLHCWQKERNHRPKFTDIVSFLDKLIRNPSALHTLVEDILVMPESPGE-----V 1067

  Fly  1028 RGQNIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKILHQARQL 1092
            ....:|::...||:.|||.:|.::|..|.......|||::...:..:|:.|:|||::|:...:.|
Human  1068 PEYPLFVTVGDWLDSIKMGQYKNNFVAAGFTTFDLISRMSIDDIRRIGVILIGHQRRIVSSIQTL 1132

  Fly  1093  1092
            Human  1133  1132

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 67/183 (37%)
FN3 387..476 CDD:238020 25/99 (25%)
FN3 536..623 CDD:238020 24/107 (22%)
EphA2_TM 644..736 CDD:291255 27/97 (28%)
PTKc_EphR 736..1002 CDD:270629 187/308 (61%)
Pkinase_Tyr 741..999 CDD:285015 183/300 (61%)
SAM_1 1033..1092 CDD:278937 18/58 (31%)
SAM 1039..1092 CDD:197735 17/52 (33%)
EPHA6XP_006713655.1 EphR_LBD_A6 128..300 CDD:198452 68/184 (37%)
fn3 427..521 CDD:278470 27/123 (22%)
FN3 537..644 CDD:238020 25/112 (22%)
EphA2_TM 664..736 CDD:291255 28/98 (29%)
PTKc_EphR_A 736..1044 CDD:270651 187/309 (61%)
Pkinase_Tyr 741..1040 CDD:285015 183/300 (61%)
SAM 1068..1135 CDD:197735 19/65 (29%)
SAM_EPH-A6 1071..1134 CDD:188946 19/62 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 121 1.000 Domainoid score I5684
eggNOG 1 0.900 - - E2759_KOG0196
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 762 1.000 Inparanoid score I548
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45908
OrthoDB 1 1.010 - - D397694at33208
OrthoFinder 1 1.000 - - FOG0000086
OrthoInspector 1 1.000 - - otm42229
orthoMCL 1 0.900 - - OOG6_100189
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X82
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.880

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