DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and EPHA10

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001092909.1	Gene:	EPHA10 / 284656	HGNCID:	19987	Length:	1008	Species:	Homo sapiens

Alignment Length:	1082	Identity:	365/1082 - (33%)
Similarity:	544/1082 - (50%)	Gaps:	148/1082 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 RMSLLRTILLIIISIHFKLAHADQVVLLDT-TREATLEWTRYPYGPQAQTPGWVEESFTDFVKGI 124
            ||.|...:||    ..::...|::|:|||: ..:|.|.||..|      :.||.|      :.|:
Human    16 RMQLCLALLL----GPWRPGTAEEVILLDSKASQAELGWTALP------SNGWEE------ISGV 64

  Fly   125 N-----WRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLL 184
            :     .|:|.||:|...|.:|||.:.:|.||...|:::|:|||:||||..||.|.:|||||::.
Human    65 DEHDRPIRTYQVCNVLEPNQDNWLQTGWISRGRGQRIFVELQFTLRDCSSIPGAAGTCKETFNVY 129

  Fly   185 FYEFDA-ATREPPPWQTDSYRLIARIAAGEGRFNQNS----DVDINTEVKSIA-VNKKGVYFAFR 243
            :.|.:| ..|..|.......|.|..|||.|. |.|..    .:.:||||:.|. ::::|.:.||:
Human   130 YLETEADLGRGRPRLGGSRPRKIDTIAADES-FTQGDLGERKMKLNTEVREIGPLSRRGFHLAFQ 193

  Fly   244 DQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCV--DNAEPYETPTYLCKG 306
            |.|||:::::|:|||..|.|.....|.|..|......:.:.:..||||  ...||...|...|..
Human   194 DVGACVALVSVRVYYKQCRATVRGLATFPATAAESAFSTLVEVAGTCVAHSEGEPGSPPRMHCGA 258

  Fly   307 DGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFK-SPEVTKCTPCPPNSNASKTGSPFCKCASG 370
            ||:|.:..|.|.|.||::..  ...|..||.|.:| ||....|:|||.:|.|.:..|.||.|...
Human   259 DGEWLVPVGRCSCSAGFQER--GDFCEACPPGFYKVSPRRPLCSPCPEHSRALENASTFCVCQDS 321

  Fly   371 FYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAI-ISWSAPAKNESFSSETNSKIYHSDIVYKI- 433
            :.|.|.|.....|..||:||.:|..........: :.|..||.:..          .||:.|.:
Human   322 YARSPTDPPSASCTRPPSAPRDLQYSLSRSPLVLRLRWLPPADSGG----------RSDVTYSLL 376

  Fly   434 -----------KCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHS 487
                       .|..|.|.|.:.|......|...||.:|.|...|||::.|:|.|
Human   377 CLRCGREGPAGACEPCGPRVAFLPRQAGLRERAATLLHLRPGARYTVRVAALNGV---------- 431

  Fly   488 NESSLVAVSDIVFSNTSLL---NIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADL 549
              |...|.:...::..::.   ..|.:.:|::..:.|    .:||.||
Human   432 --SGPAAAAGTTYAQVTVSTGPGAPWEEDEIRRDRVE----PQSVSLS----------------- 473

  Fly   550 EWDKPVQSDFP----LEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNN 610
             |.:|:.:..|    .| ||:|::.|.:.:. ..|.:.|......:..|...|.|.||:|..:..
Human   474 -WREPIPAGAPGANDTE-YEIRYYEKGQSEQ-TYSMVKTGAPTVTVTNLKPATRYVFQIRAASPG 535

  Fly   611 ---GFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDK 672
               ...|::..|..|||....|...|  |...|...:||....||:..:.:|..:..:
Human   536 PSWEAQSFNPSIEVQTLGEAASGSRD--QSPAIVVTVVTISALLVLGSVMSVLAIWRR------- 591

  Fly   673 KSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREID 737
                    |..|.....::.|...:.  .|..|.|     .|:::||.:..|..||:..||:|:|
Human   592 --------PCSYGKGGGDAHDEEELY--FHFKVPT-----RRTFLDPQSCGDLLQAVHLFAKELD 641

  Fly   738 ANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHP 802
            |..:|:|..:|||.||::|.|.|::|..  |::.||:..|:..:|:..|..||.||..:|||||.
Human   642 AKSVTLERSLGGGRFGELCCGCLQLPGR--QELLVAVHMLRDSASDSQRLGFLAEALTLGQFDHS 704

  Fly   803 NVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHR 867
            :::.|:|||||.:.:||:||||.:|:||.|||.::|:....||:.:|.|:||.|.|||:|.||||
Human   705 HIVRLEGVVTRGSTLMIVTEYMSHGALDGFLRRHEGQLVAGQLMGLLPGLASAMKYLSEMGYVHR 769

  Fly   868 DLAARNVLVNAQLICKIADFGLSREIENASDA-YTTRGGKIPVRWTAPEAIAFRKFTSASDVWSY 931
            .||||:|||::.|:|||:.||  |...:.|:| |||..|:.|..|.|||.:.|..|:|||||||:
Human   770 GLAARHVLVSSDLVCKISGFG--RGPRDRSEAVYTTMSGRSPALWAAPETLQFGHFSSASDVWSF 832

  Fly   932 GVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIV 996
            |:::||||::||||||:.|.|||||::|.|:|||.|.:||..|::||||||||....||.|:.|.
Human   833 GIIMWEVMAFGERPYWDMSGQDVIKAVEDGFRLPPPRNCPNLLHRLMLDCWQKDPGERPRFSQIH 897

  Fly   997 STLDNLARQPQ---SLLTTRPSPESDGNHILDGQRGQNIFI---STDLWLEHIKMSRYCHHFKEA 1055
            |.|..:.:.|:   ..|||.|.|.:.   :.|  |..:.|.   |...|||.:.:.||...|..|
Human   898 SILSKMVQDPEPPKCALTTCPRPPTP---LAD--RAFSTFPSFGSVGAWLEALDLCRYKDSFAAA 957

  Fly  1056 NLINAQQISRLTAQQLSDMGITLVGHQKKILH-----QARQL 1092
            ...:.:.::.:|||.|..:||:|..|::.:|.     |||.|
Human   958 GYGSLEAVAEMTAQDLVSLGISLAEHREALLSGISALQARVL 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	70/186 (38%)
		FN3	387..476	CDD:238020	24/101 (24%)
		FN3	536..623	CDD:238020	18/93 (19%)
		EphA2_TM	644..736	CDD:291255	19/91 (21%)
		PTKc_EphR	736..1002	CDD:270629	136/266 (51%)
		Pkinase_Tyr	741..999	CDD:285015	133/258 (52%)
		SAM_1	1033..1092	CDD:278937	21/66 (32%)
		SAM	1039..1092	CDD:197735	19/57 (33%)
EPHA10	NP_001092909.1	EphR_LBD	35..210	CDD:295439	70/187 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..342		7/19 (37%)
		fn3	339..431	CDD:278470	24/101 (24%)
		FN3	451..531	CDD:238020	22/103 (21%)
		EphA2_TM	573..640	CDD:291255	17/88 (19%)
		PTKc_EphR_A10	639..904	CDD:133195	137/268 (51%)
		Pkinase_Tyr	645..900	CDD:285015	133/258 (52%)
		SAM_superfamily	929..998	CDD:301707	20/68 (29%)
		SAM	932..997	CDD:197735	19/64 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5684
eggNOG	1	0.900	-	-		E2759_KOG0196
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D397694at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42229
orthoMCL	1	0.900	-	-		OOG6_100189
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X82
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.820