DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eph and Axl

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:NP_033491.2 Gene:Axl / 26362 MGIID:1347244 Length:888 Species:Mus musculus


Alignment Length:976 Identity:235/976 - (24%)
Similarity:376/976 - (38%) Gaps:276/976 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   145 SPFID--------RGSANRLYIEIQFT--------IRDCSLFPGNALSCKETFSLLFYEFDAATR 193
            |||:.        ||....|..|:|..        :||     |..|...:         :..|:
Mouse    29 SPFVGNPGNITGARGLTGTLRCELQVQGEPPEVVWLRD-----GQILELAD---------NTQTQ 79

  Fly   194 EP--PPWQTDSYRLIARIAAGEGRFNQNSDVDINTEVKSIAVNKKGVYFAFRDQGACISVLAVKV 256
            .|  ..|| |.:::::::                 .:.::.::..|.|       .|:..|..:.
Mouse    80 VPLGEDWQ-DEWKVVSQL-----------------RISALQLSDAGEY-------QCMVHLEGRT 119

  Fly   257 YYITCPAVT--ENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRC 319
             :::.|...  |...:|.|.|.               |.|.|..||..|            .|:.
Mouse   120 -FVSQPGFVGLEGLPYFLEEPE---------------DKAVPANTPFNL------------SCQA 156

  Fly   320 KAGYEPNYTNKTCTECPLG--TFKSPEVTKCTPCPPNSNASKTGSPFCKC--ASGFYRHPNDGRH 380
            :...||..........||.  |..|.:.:..||     ..:||.|..|:.  |.|.    ...|.
Mouse   157 QGPPEPVTLLWLQDAVPLAPVTGHSSQHSLQTP-----GLNKTSSFSCEAHNAKGV----TTSRT 212

  Fly   381 MPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI-KCN---ICSPN 441
            ......|..|.:|.::....|...::|:.....                :|.: .||   :.|.:
Mouse   213 ATITVLPQRPHHLHVVSRQPTELEVAWTPGLSG----------------IYPLTHCNLQAVLSDD 261

  Fly   442 VV------YNPSTDTFN------ETKITLTNLEPVTTYTVQIHAINSV-----SHINEFKRHSNE 489
            .|      .:|..|...      ..::.|..|.|.|.|.::|...:|.     :|.         
Mouse   262 GVGIWLGKSDPPEDPLTLQVSVPPHQLRLEKLLPHTPYHIRISCSSSQGPSPWTHW--------- 317

  Fly   490 SSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADL-EWDK 553
                              :|::             |||.|.|....|  :.|:.|....| .|.:
Mouse   318 ------------------LPVE-------------TTEGVPLGPPEN--VSAMRNGSQVLVRWQE 349

  Fly   554 PVQSDFPLE--------FYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNN 610
            |   ..||:        .|..:..|:|.:|.    .| |:|....:.|..........|...|:.
Mouse   350 P---RVPLQGTLLGYRLAYRGQDTPEVLMDI----GL-TREVTLELRGDRPVANLTVSVTAYTSA 406

  Fly   611 GFGSYSNMIYAQTL-----QSVGSVYDDSVQIRF-------IAGAIVTG--VLFLVIFIIATVYF 661
            |.|.:|..:..:..     |.:..:..:.....|       :.||:|..  ||.|.:|::     
Mouse   407 GDGPWSLPVPLEPWRPGQGQPLHHLVSEPPPRAFSWPWWYVLLGALVAAACVLILALFLV----- 466

  Fly   662 MRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPN 726
                |:   .||.|.:         .||    ..|.|::..|.|.   :...:||....|....|
Mouse   467 ----HR---RKKETRY---------GEV----FEPTVERGELVVR---YRVRKSYSRRTTEATLN 508

  Fly   727 -----QAIREFARE--IDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQD---IDVAIKTLKPGS 781
                 :.::|..|:  :|.:.:.:...:|.||||.|..|:|.      ||   :.||:||:|...
Mouse   509 SLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLN------QDDSILKVAVKTMKIAI 567

  Fly   782 SEKARC-DFLTEASIMGQFDHPNVIYLQGVVTRSN-------PVMIITEYMENGSLDTFL---RV 835
            ..::.. |||:||..|.:||||||:.|.||..:.:       ||:|: .:|::|.|.:||   |:
Mouse   568 CTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSDREGFPEPVVIL-PFMKHGDLHSFLLYSRL 631

  Fly   836 NDGK--FQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASD 898
            .|..  ..|..|:..:..|||||.|||...::||||||||.::|..:...:||||||::|.|...
Mouse   632 GDQPVFLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDY 696

  Fly   899 AYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYR 963
            ....|..|:||:|.|.|::|.|.:||.|||||:||.:||:.:.|:.||....|.::...:.:|.|
Mouse   697 YRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNR 761

  Fly   964 LPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNL------ARQPQSLLTTRPSPESDGNH 1022
            |..|:||.:.||.||..||:.....||:||.:...|:|.      |::|..:|..  :.:..|:|
Mouse   762 LKQPVDCLDGLYALMSRCWELNPRDRPSFAELREDLENTLKALPPAQEPDEILYV--NMDEGGSH 824

  Fly  1023 I 1023
            :
Mouse   825 L 825

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 21/132 (16%)
FN3 387..476 CDD:238020 18/104 (17%)
FN3 536..623 CDD:238020 21/95 (22%)
EphA2_TM 644..736 CDD:291255 21/100 (21%)
PTKc_EphR 736..1002 CDD:270629 109/281 (39%)
Pkinase_Tyr 741..999 CDD:285015 107/273 (39%)
SAM_1 1033..1092 CDD:278937
SAM 1039..1092 CDD:197735
AxlNP_033491.2 Interaction with GAS6. /evidence=ECO:0000250 19..86 14/70 (20%)
Ig 47..114 CDD:319273 15/105 (14%)
Ig 135..216 CDD:386229 25/116 (22%)
FN3 219..322 CDD:238020 21/158 (13%)
fn3 329..411 CDD:365830 20/91 (22%)
PTKc_Axl 529..805 CDD:270660 109/282 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 820..846 2/6 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 865..888
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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