DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eph and Tyro3

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:NP_058788.1 Gene:Tyro3 / 25232 RGDID:3923 Length:880 Species:Rattus norvegicus


Alignment Length:703 Identity:182/703 - (25%)
Similarity:285/703 - (40%) Gaps:194/703 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   385 SPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPS-- 447
            :|||||.|:|:..:..::|.::|...|...:        :.||          |:..|.:.|.  
  Rat   213 APPAAPFNITVTTISSSNASVAWVPGADGLA--------LLHS----------CTVQVAHAPGEW 259

  Fly   448 --------TDTFNETKITLTNLEPVTTYTVQIHAINSV--SHINEFKRHSNESSLVAVSDIVFSN 502
                    ...|.   ..|.||.|.|.|::::...|::  |...::              :.|..
  Rat   260 EALAVVVPVPPFT---CLLRNLAPATNYSLRVRCANALGPSPYGDW--------------VPFQT 307

  Fly   503 TSL--LNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSD---FPLE 562
            ..|  ...|.:.:.::|....|                          |||::.:..|   .||.
  Rat   308 KGLAPARAPQNFHAIRTDSGLI--------------------------LEWEEVIPEDPGEGPLG 346

  Fly   563 FYEVRWFPKVELDAINKSALNTKETKAHIVGLLEN-TEYGFQ----VR-CKTNN-GFGSYSNMIY 620
            .|::.|..:           |..:.:..:.|...| |::..|    :| |.:|. |.|.:|..:.
  Rat   347 PYKLSWVQE-----------NGTQDELMVEGTTANLTDWDPQKDLVLRVCASNAIGDGPWSQPLV 400

  Fly   621 AQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYA 685
            ..:....|.......:..::  .:|.|||..:|...|....:..|.     :|.|.         
  Rat   401 VSSHDHAGRQGPPHSRTSWV--PVVLGVLTALITAAALALILLRKR-----RKETR--------- 449

  Fly   686 SNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYV----DPHTYEDPNQAIREFARE----------- 735
                                    ||.:...|    :|..:   .:|.|.|.||           
  Rat   450 ------------------------FGQAFDSVMARGEPAVH---FRAARSFNRERPERIEATLDS 487

  Fly   736 ---------------IDANYITIEAIIGGGEFGDVCRGRLKIPP-NFVQDIDVAIKTLKP---GS 781
                           |.....|:..::|.||||.|...:||... :||:   ||:|.||.   .|
  Rat   488 LGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVK---VAVKMLKADIIAS 549

  Fly   782 SEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSN-----PV-MIITEYMENGSLDTFL---RVND 837
            |:..  :||.||:.|.:||||:|..|.||..||.     |: |:|..:|::|.|..||   |:.:
  Rat   550 SDIE--EFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGE 612

  Fly   838 GKFQ-TLQLIV-MLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAY 900
            ..|. .||.:| .:..||.||.|||..|::||||||||.::...:...:|||||||:|  .|..|
  Rat   613 NPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKI--YSGDY 675

  Fly   901 TTRG--GKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYR 963
            ..:|  .|:||:|.|.|::|...:|..||||::||.:||:|:.|:.||....|.::...:..|.|
  Rat   676 YRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLISGNR 740

  Fly   964 LPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSP 1016
            |..|.:|.|.:|.||..||......||:|..:...|:|:... .|:|:|...|
  Rat   741 LKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGH-LSVLSTSQDP 792

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439
FN3 387..476 CDD:238020 21/98 (21%)
FN3 536..623 CDD:238020 19/96 (20%)
EphA2_TM 644..736 CDD:291255 18/121 (15%)
PTKc_EphR 736..1002 CDD:270629 110/282 (39%)
Pkinase_Tyr 741..999 CDD:285015 108/274 (39%)
SAM_1 1033..1092 CDD:278937
SAM 1039..1092 CDD:197735
Tyro3NP_058788.1 IG_like 39..125 CDD:214653
IGc2 46..111 CDD:197706
Ig2_Tyro3_like 131..209 CDD:143226
IG_like 135..204 CDD:214653
FN3 215..307 CDD:238020 24/126 (19%)
fn3 315..396 CDD:278470 21/117 (18%)
PTKc_Tyro3 498..781 CDD:270659 111/289 (38%)
Pkinase_Tyr 508..776 CDD:285015 108/274 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 804..827
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 842..864
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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