DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and Insr

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_058767.2	Gene:	Insr / 24954	RGDID:	2917	Length:	1384	Species:	Rattus norvegicus

Alignment Length:	1101	Identity:	266/1101 - (24%)
Similarity:	426/1101 - (38%)	Gaps:	303/1101 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 GWVEESFTDFVKGINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNAL 175
            |.:|| .:.|:| |. |||.:..:::....:.:....::.|:.:...::.| .:|  .|:..|..
  Rat   386 GLIEE-ISGFLK-IR-RSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQ-NLR--QLWDWNKH 444

  Fly   176 SCKETFSLLFYEFDAATREPPPWQTDSYRLIARIAAGEGRFNQNSDVDINTEVKSIAVNKKGVYF 240
            :...|...||:.::      |.........:..::..:||..:| |:.:.|.....:...:.:.|
  Rat   445 NLTITQGKLFFHYN------PKLCLSEIHKMEEVSGTKGRQERN-DIALKTNGDQASCENELLKF 502

  Fly   241 A--------------------FRDQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEK 285
            :                    |||      :|...::|...|  .:|...|:    |::  ....
  Rat   503 SFIRTSFDKILLRWEPYWPPDFRD------LLGFMLFYKEAP--YQNVTEFD----GQD--ACGS 553

  Fly   286 QNGTCVDNAEPYET----------PTYLCKGDGKWTIL---------------TGGCRCKAGY-E 324
            .:.|.||...|..:          |.:|.:|...||..               |.|.:....| :
  Rat   554 NSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQ 618

  Fly   325 PNYTNKTCTECPLGTFKSPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAA 389
            .:.||             |.|    |..|.|.::.:.....|                 :.||:.
  Rat   619 TDATN-------------PSV----PLDPISVSNSSSQIILK-----------------WKPPSD 649

  Fly   390 PT-NLTLLFV-----DQTSAII--------------SWSAPAKNESFSSETNSKIYHSDIVY--- 431
            |. |:|...|     .:.|.:.              :||.|     |.|:.:.|  |:...|
  Rat   650 PNGNITHYLVYWERQAEDSELFELDYCLKGLKLPSRTWSPP-----FESDDSQK--HNQSEYDDS 707

  Fly   432 KIKCNICSPNVVYNPSTDTFNETKITLTNLEPVT---TYTVQIHAI-------NSVSHINEFKRH 486
            ..:|..|       |.||:     ..|..||..:   |:...:|.:       :|.:...:.:..
  Rat   708 ASECCSC-------PKTDS-----QILKELEESSFRKTFEDYLHNVVFVPRKTSSGNGAEDTRPS 760

  Fly   487 SNESSLVAVSDIV--------FSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLS-----TVFNLR 538
            ....||..|.::.        |.|.|....|....|.:  ..|.|...||:::|     |.:.:.
  Rat   761 RKRRSLEEVGNVTATTPTLPDFPNISSTIAPTSHEEHR--PFEKVVNKESLVISGLRHFTGYRIE 823

  Fly   539 ILAITNKD---------------------AD-----------------LEWDKPVQSDFPLEFYE 565
            :.| .|:|                     ||                 |.|.:|.:.:..:..||
  Rat   824 LQA-CNQDSPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYE 887

  Fly   566 V--RWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVG 628
            |  |.:...||...........|....:.||... .|..:||..:..|.||::...|...
  Rat   888 VSYRRYGDEELHLCVSRKHFALERGCRLRGLSPG-NYSVRVRATSLAGNGSWTEPTYFYV----- 946

  Fly   629 SVYDDSVQI-RFIAGAIVTGVLFLVIF--IIATVY-FMRSKHQDDLDKKSTNHLPLPLDYASNE- 688
               .|.:.: ..||..|:..::|:.:|  :|.::| |:|.:..|.         |:...|||:.
  Rat   947 ---TDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDG---------PMGPLYASSNP 999

  Fly   689 --VNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGE 751
              :::.|..|                |..|| |..:|.|.:.            ||:...:|.|.
  Rat  1000 EYLSASDVFP----------------SSVYV-PDEWEVPREK------------ITLLRELGQGS 1035

  Fly   752 FGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNP 816
            ||.|..|..|.......:..||:||:...:|.:.|.:||.|||:|..|...:|:.|.|||::..|
  Rat  1036 FGMVYEGNAKDIIKGEVETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQP 1100

  Fly   817 VMIITEYMENGSLDTFLRV-------NDGK-FQTLQ-LIVMLRGIASGMSYLSDMNYVHRDLAAR 872
            .:::.|.|.:|.|.:.||.       |.|: ..||| :|.|...||.||:||:...:||||||||
  Rat  1101 TLVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAAR 1165

  Fly   873 NVLVNAQLICKIADFGLSREIENASDAYTTRGGK--IPVRWTAPEAIAFRKFTSASDVWSYGVVL 935
            |.:|......||.|||::|:|....  |..:|||  :||||.:||::....||::||:||:||||
  Rat  1166 NCMVAHDFTVKIGDFGMTRDIYETD--YYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVL 1228

  Fly   936 WEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTL- 999
            ||:.|..|:||...||:.|:|.:..|..|..|.:|||.|..||..|||.....||||..||:.|
  Rat  1229 WEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLK 1293

  Fly  1000 DNLARQPQSLLTTRPS-PE-----SDGNHILDGQRGQNIFISTDLWLEHIKMSRYCHHFKE 1054
            |:|          .|| ||     |:.|...:.:..:..|..    :|::.:.|..|..:|
  Rat  1294 DDL----------HPSFPEVSFFYSEENKAPESEELEMEFED----MENVPLDRSSHCQRE 1340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	29/168 (17%)
		FN3	387..476	CDD:238020	24/121 (20%)
		FN3	536..623	CDD:238020	24/126 (19%)
		EphA2_TM	644..736	CDD:291255	20/97 (21%)
		PTKc_EphR	736..1002	CDD:270629	114/277 (41%)
		Pkinase_Tyr	741..999	CDD:285015	112/268 (42%)
		SAM_1	1033..1092	CDD:278937	5/22 (23%)
		SAM	1039..1092	CDD:197735	4/16 (25%)
Insr	NP_058767.2	Recep_L_domain	52..164	CDD:279382
		Furin-like	179..337	CDD:279142
		FU	234..281	CDD:238021
		Recep_L_domain	359..472	CDD:279382	18/97 (19%)
		FN3	624..>667	CDD:238020	12/63 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..710		7/28 (25%)
		Insulin-binding. /evidence=ECO:0000250	735..743		1/7 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..784		5/35 (14%)
		FN3	869..946	CDD:238020	19/77 (25%)
		Important for interaction with IRS1, SHC1 and STAT5B	998..1001		0/2 (0%)
		PTKc_InsR	1018..1305	CDD:133192	121/310 (39%)
		Pkinase_Tyr	1025..1292	CDD:285015	112/268 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1362..1384
		PIK3R1 binding. /evidence=ECO:0000250	1363..1366
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910