DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and EPHB6

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_004436.4	Gene:	EPHB6 / 2051	HGNCID:	3396	Length:	1022	Species:	Homo sapiens

Alignment Length:	1130	Identity:	355/1130 - (31%)
Similarity:	549/1130 - (48%)	Gaps:	207/1130 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 ISEQNRSQIVSRMSLLRTILLIIISIHFKLAHADQVVLLDTTREAT-LEWTRYPYGPQAQTPGWV 113
            ::.:..:|:.:|::.:...|.:::.:...||..:  ||||||.|.: :.|..||.|      ||.
Human     1 MATEGAAQLGNRVAGMVCSLWVLLLVSSVLALEE--VLLDTTGETSEIGWLTYPPG------GWD 57

  Fly   114 EESFTDFVKGINWRSYVVCDVA----YHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNA 174
            |.|..|..:.:. |::..|.||    ....:|||.:.|::|..|.|.:|.:.|::|.||....:.
Human    58 EVSVLDDQRRLT-RTFEACHVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSG 121

  Fly   175 LSCKETFSLLFYEFDAATREP------PPWQTDSYRLIARIAAGEG------------------- 214
            .:|:|||:|.:.:    ..||      ..|....:..:..|||.|.
Human   122 GTCRETFTLYYRQ----AEEPDSPDSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSSAAWAV 182

  Fly   215 ---RFNQNSDVDINTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAHFNET- 274
               ...|.:.:.:|.:.:|.. :.::|.|.||:|.|||::::||:::..|||||..:||.|.||
Human   183 GPHGAGQRAGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFASFPETQ 247

  Fly   275 PTGREITIIEKQNGTCVDNAEPYE----------TPTYLCKGDGKWTILTGGCRCKAGYEPNYTN 329
            .:|.....:....||||.:|||.|          .|...|.|:|||.:..|||||:.||:|...:
Human   248 ASGAGGASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCRCQPGYQPARGD 312

  Fly   330 KTCTECPLGTFK-SPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNL 393
            |.|..||.|.:| |.....|:|||..|:|....:|.|.|..||||..:|....||..||:||..
Human   313 KACQACPRGLYKASAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSAPQE- 376

  Fly   394 TLLFVDQTSAI-ISWSAPAKNESFSSETNSKIYHSDIVYKI-----------------KCNICSP 440
             |.|..|.||: :.|..|       .|...:   .|:::.:                 .|:.|..
Human   377 -LWFEVQGSALMLHWRLP-------RELGGR---GDLLFNVVCKECEGRQEPASGGGGTCHRCRD 430

  Fly   441 NVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSH----------INEFKRHSNESSLVAV 495
            .|.::|......|:::.:..|.....|.:::.|:|.||.          ||....|...|::..|
Human   431 EVHFDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVV 495

  Fly   496 SDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFP 560
            ..:..::.|:                                          .:.|.:|.|::..
Human   496 HQVSRASNSI------------------------------------------TVSWPQPDQTNGN 518

  Fly   561 LEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQ 625
            :..|::|::.:.| |..:...|.::...|.:..|.....||||||.:|..|.|.|...:|.|||.
Human   519 ILDYQLRYYDQAE-DESHSFTLTSETNTATVTQLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLP 582

  Fly   626 SVGSVYDDSVQIRFIAGAIVTGVLFLVI--FIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNE 688
            ..........::..:.|:|:..:.||::  ..:..|.|.|.       ::.|.:......|:|
Human   583 QGELSSQLPERLSLVIGSILGALAFLLLAAITVLAVVFQRK-------RRGTGYTEQLQQYSS-- 638

  Fly   689 VNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFG 753
                               |..| .:.|:||.|||||.|||||.|||:|..||.||.:||.|.||
Human   639 -------------------PGLG-VKYYIDPSTYEDPCQAIRELAREVDPAYIKIEEVIGTGSFG 683

  Fly   754 DVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVM 818
            :|.:|||:  |...::..|||:.|..|.:|..:..||..|:::|||.|||::.|:||||:|.|:|
Human   684 EVRQGRLQ--PRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNILRLEGVVTKSRPLM 746

  Fly   819 IITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICK 883
            ::||:||.|.||:|||..:|:|.:|||:.|.||:|:.|.|||...:|||.|:|.:||||:.|:||
Human   747 VLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCK 811

  Fly   884 IADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWN 948
            :|..|           ::.:|....:||.|||.||..|.|::|||||:|:::||||||||||||:
Human   812 VARLG-----------HSPQGPSCLLRWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWD 865

  Fly   949 WSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTR 1013
            .|.|:|:.:||:.:|||.|..||..|:.||||.|||.|..||.|..:|:..|.:.|:|.:|
Human   866 MSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIRKPDTL---- 926

  Fly  1014 PSPESDGNHILDGQRGQNIFI-----------STDLWLEHIKMSRYCHHFKEANLINAQQISRLT 1067
               ::.|:   .|:|.....:           |...||..|.:..|..:|.:..|.....:::|:
Human   927 ---QAGGD---PGERPSQALLTPVALDFPCLDSPQAWLSAIGLECYQDNFSKFGLCTFSDVAQLS 985

  Fly  1068 AQQLSDMGITLVGHQKKILHQARQL 1092
            .:.|..:||||.|||||:||..:.|
Human   986 LEDLPALGITLAGHQKKLLHHIQLL 1010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	57/208 (27%)
		FN3	387..476	CDD:238020	20/106 (19%)
		FN3	536..623	CDD:238020	21/86 (24%)
		EphA2_TM	644..736	CDD:291255	26/93 (28%)
		PTKc_EphR	736..1002	CDD:270629	128/265 (48%)
		Pkinase_Tyr	741..999	CDD:285015	125/257 (49%)
		SAM_1	1033..1092	CDD:278937	20/69 (29%)
		SAM	1039..1092	CDD:197735	19/52 (37%)
EPHB6	NP_004436.4	EphR_LBD_B6	33..232	CDD:198443	57/211 (27%)
		Ephrin_rec_like	305..346	CDD:311571	16/40 (40%)
		FN3	371..472	CDD:238020	23/112 (21%)
		fn3	490..572	CDD:306538	22/124 (18%)
		EphA2_TM	613..665	CDD:317033	22/80 (28%)
		PKc_like	666..920	CDD:328722	128/266 (48%)
		SAM_EPH-B6	946..1014	CDD:188954	21/65 (32%)
		PDZ-binding. /evidence=ECO:0000255	1020..1022
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5684
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	762	1.000	Inparanoid score	I548
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D397694at33208
OrthoFinder	1	1.000	-	-		FOG0000086
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100189
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X82
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.870