Protein Alignment Eph and EPHA7

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: NP_004431.1
• Gene: EPHA7 / 2045
• HGNCID: 3390
• Length: 998
• Species: Homo sapiens
• Alignment Length: 1076
• Identity: 450/1076 - (41%)
• Similarity: 619/1076 - (57%)
• Gaps: 165/1076 - (15%)

  Fly    68 ILLIIISIHFKLAH------ADQVVLLDTTREAT-LEWTRYPYGPQAQTPGW-----VEESFTDF 120
            |:|..|.: .:.||      |.:|:|||:..:.| |||...|  |.    ||     ::|::|..
Human    11 IILCYIWL-LRFAHTGEAQAAKEVLLLDSKAQQTELEWISSP--PN----GWEEISGLDENYTPI 68

  Fly   121 VKGINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLF 185
                  |:|.||.|...|.||||.:.:|.:|:|.|:::|::||:|||:..||...:|||||:|.:
Human    69 ------RTYQVCQVMEPNQNNWLRTNWISKGNAQRIFVELKFTLRDCNSLPGVLGTCKETFNLYY 127

  Fly   186 YEFDAAT----REPPPWQTDSYRLIARIAAGEGRFNQNS----DVDINTEVKSIA-VNKKGVYFA 241
            ||.|..|    ||      :.|..|..|||.|. |.|..    .:.:||||:.|. ::|||.|.|
Human   128 YETDYDTGRNIRE------NLYVKIDTIAADES-FTQGDLGERKMKLNTEVREIGPLSKKGFYLA 185

  Fly   242 FRDQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNA--EPYETPTYLC 304
            |:|.||||::::|||||..|.::.||.|.|.:|.||.|.:.:.:..||||.:|  |....|...|
Human   186 FQDVGACIALVSVKVYYKKCWSIIENLAIFPDTVTGSEFSSLVEVRGTCVSSAEEEAENAPRMHC 250

  Fly   305 KGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFK-SPEVTKCTPCPPNSNASKTGSPFCKCA 368
            ..:|:|.:..|.|.|||||:..  ..||..|..|.:| |.:..:|:.||.:|.:.|.||..|:|.
Human   251 SAEGEWLVPIGKCICKAGYQQK--GDTCEPCGRGFYKSSSQDLQCSRCPTHSFSDKEGSSRCECE 313

  Fly   369 SGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI 433
            .|:||.|:|..::.|..||:||.|| :..::||:..:.||.||.|..          .:|:.|:|
Human   314 DGYYRAPSDPPYVACTRPPSAPQNL-IFNINQTTVSLEWSPPADNGG----------RNDVTYRI 367

  Fly   434 KCNICS----------PNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSN 488
            .|..||          .|:.|.|......:..:|:.:|.....||.::.|:|.||.::..:|
Human   368 LCKRCSWEQGECVPCGSNIGYMPQQTGLEDNYVTVMDLLAHANYTFEVEAVNGVSDLSRSQR--- 429

  Fly   489 ESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDK 553
                      :|:..|          :.||||      ....:|.|...|:|   .:..:|.|.:
Human   430 ----------LFAAVS----------ITTGQA------APSQVSGVMKERVL---QRSVELSWQE 465

  Fly   554 PVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNM 618
            |...:..:..||::::.|.:.:. ..|.:.||.|.|.|..|...|.|.||:|..|..|:|:||..
Human   466 PEHPNGVITEYEIKYYEKDQRER-TYSTVKTKSTSASINNLKPGTVYVFQIRAFTAAGYGNYSPR 529

  Fly   619 IYAQTL-QSVGSVYD------DSVQIRFIAGAIVTGVLFLVI----FIIATVYFMRSKHQDDLDK 672
            :...|| ::.|.:::      :...:..||...|.|.:.||.    |||...:...||...:.|:
Human   530 LDVATLEEATGKMFEATAVSSEQNPVIIIAVVAVAGTIILVFMVFGFIIGRRHCGYSKADQEGDE 594

  Fly   673 KSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREID 737
            :...|...|                              .:::|:||.||||||:|:.:||:|:|
Human   595 ELYFHFKFP------------------------------GTKTYIDPETYEDPNRAVHQFAKELD 629

  Fly   738 ANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHP 802
            |:.|.||.:||.||||:||.||||:|..  :|:.|||||||.|.:||.|.|||.|||||||||||
Human   630 ASCIKIERVIGAGEFGEVCSGRLKLPGK--RDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHP 692

  Fly   803 NVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHR 867
            ||::|:|||||..||||:.|:||||:||.|||.:||:|..:||:.||||||:||.||:||.||||
Human   693 NVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHR 757

  Fly   868 DLAARNVLVNAQLICKIADFGLSREIENASDA-YTTRGGKIPVRWTAPEAIAFRKFTSASDVWSY 931
            ||||||:|||:.|:||::||||||.||:..:| |||.||||||||||||||.:||||||||||||
Human   758 DLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSY 822

  Fly   932 GVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIV 996
            |:|:||||||||||||:.|||||||:||:|||||||||||..|:|||||||||:|..||.|..||
Human   823 GIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIV 887

  Fly   997 STLDNLARQPQSLLT-----TRP-SPESDGNHILDGQRGQN-----IFISTDLWLEHIKMSRYCH 1050
            ..||.:.|.|.||.|     :|| ||      :||    ||     .|.|...||:.|||.||..
Human   888 GILDKMIRNPNSLKTPLGTCSRPISP------LLD----QNTPDFTTFCSVGEWLQAIKMERYKD 942

  Fly  1051 HFKEANLINAQQISRLTAQQLSDMGITLVGHQKKIL 1086
            :|..|...:.:.::|:|.:.:..:|||||||||||:
Human   943 NFTAAGYNSLESVARMTIEDVMSLGITLVGHQKKIM 978

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	77/189 (41%)
		FN3	387..476	CDD:238020	26/98 (27%)
		FN3	536..623	CDD:238020	25/86 (29%)
		EphA2_TM	640..738	CDD:464211	27/101 (27%)
		PTKc_EphR	736..1002	CDD:270629	189/266 (71%)
		SAM_1	1029..1092	CDD:425739	26/63 (41%)
EPHA7	NP_004431.1	EphR_LBD_A7	30..206	CDD:198453	78/194 (40%)
		FN3	<314..>539	CDD:442628	72/268 (27%)
		FN3	443..534	CDD:238020	27/94 (29%)
		EphA2_TM	565..630	CDD:464211	24/94 (26%)
		PTKc_EphR_A	628..894	CDD:270651	189/267 (71%)
		SAM_EPH-A7	919..988	CDD:188947	24/60 (40%)
		PDZ-binding. /evidence=ECO:0000255	996..998