DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eph and EPHA2

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:NP_004422.2 Gene:EPHA2 / 1969 HGNCID:3386 Length:976 Species:Homo sapiens


Alignment Length:1061 Identity:407/1061 - (38%)
Similarity:568/1061 - (53%) Gaps:157/1061 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 AHADQVVLLD-TTREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCDVAYHNVNNWL 143
            |...:||||| ......|.|..:|||     .||  :...:.:..:....|.||:|...:.:|||
Human    24 AQGKEVVLLDFAAAGGELGWLTHPYG-----KGW--DLMQNIMNDMPIYMYSVCNVMSGDQDNWL 81

  Fly   144 WSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYE--FDAATREPPPWQTDSYRLI 206
            .:.::.||.|.|::||::||:|||:.|||.|.||||||:|.:.|  .|..|.    :|...:..|
Human    82 RTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTN----FQKRLFTKI 142

  Fly   207 ARIAAGEGRFNQNSD-----VDINTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCPAVT 265
            ..||..|  ...:||     |.:|.|.:|:. :.:||.|.||:|.|||:::|:|:|||..||.:.
Human   143 DTIAPDE--ITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELL 205

  Fly   266 ENFAHFNETPTGREITIIEKQNGTCVDNA---EPYETPTYLCKGDGKWTILTGGCRCKAGYEPNY 327
            :..|||.||..|.:...:....|||||:|   ...|.|...|..||:|.:..|.|.|:||||.  
Human   206 QGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEK-- 268

  Fly   328 TNKTCTECPLGTFK-----SPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPP 387
            ....|..|..|.||     ||    |..||.::..|..|:..|:|..||:|.|.|...|||..||
Human   269 VEDACQACSPGFFKFEASESP----CLECPEHTLPSPEGATSCECEEGFFRAPQDPASMPCTRPP 329

  Fly   388 AAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSP----------NV 442
            :||..||.:.:. ....:.|:.|  .:|...|        ||||.:.|..|.|          :|
Human   330 SAPHYLTAVGMG-AKVELRWTPP--QDSGGRE--------DIVYSVTCEQCWPESGECGPCEASV 383

  Fly   443 VYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLN 507
            .|:........|.:|:::|||...||..:.|.|                  .||.:|.|.:    
Human   384 RYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARN------------------GVSGLVTSRS---- 426

  Fly   508 IPLDLNEVKTGQAEIVFTTESVLLSTVF--NLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFP 570
                            |.|.||.::...  .:|:...:.....:.|..|......:..|||.:..
Human   427 ----------------FRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRK 475

  Fly   571 KVELDAINKSALNTKETKAHIV---GLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYD 632
            |.:     .::.|.:.|:...|   .|..:|.|..||:..|..|.|:.|.:...|||...|    
Human   476 KGD-----SNSYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEG---- 531

  Fly   633 DSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPI 697
             |..:..|.|..|..||.||:..:.  :|:..:.::...::|    |..:.::.:|         
Human   532 -SGNLAVIGGVAVGVVLLLVLAGVG--FFIHRRRKNQRARQS----PEDVYFSKSE--------- 580

  Fly   698 VKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKI 762
                   ...||    ::|||||||||||||:.:|..||..:.:|.:.:||.||||:|.:|.||.
Human   581 -------QLKPL----KTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKT 634

  Fly   763 PPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENG 827
            ... .:::.|||||||.|.:||.|.|||.||.|||||.|.|:|.|:||:::..|:||||||||||
Human   635 SSG-KKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENG 698

  Fly   828 SLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSRE 892
            :||.|||..||:|..|||:.||||||:||.||::||||||||||||:|||:.|:||::||||||.
Human   699 ALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRV 763

  Fly   893 IENASDA-YTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIK 956
            :|:..:| |||.|||||:||||||||::|||||||||||:|:|:||||:|||||||..||.:|:|
Human   764 LEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMK 828

  Fly   957 SIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLT-----TRPS- 1015
            :|..|:|||.|||||.|:||||:.|||::|..||.||.|||.||.|.|.|.||.|     .|.| 
Human   829 AINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSI 893

  Fly  1016 --PESDGNHILDGQRGQNIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITL 1078
              |.:.|:..:.       |.:...|||.|||.:|..||..|.....:::.::|...:..:|:.|
Human   894 RLPSTSGSEGVP-------FRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRL 951

  Fly  1079 VGHQKKILHQ----ARQLDTI 1095
            .||||:|.:.    ..|::|:
Human   952 PGHQKRIAYSLLGLKDQVNTV 972

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 69/183 (38%)
FN3 387..476 CDD:238020 26/98 (27%)
FN3 536..623 CDD:238020 19/89 (21%)
EphA2_TM 644..736 CDD:291255 25/91 (27%)
PTKc_EphR 736..1002 CDD:270629 169/266 (64%)
Pkinase_Tyr 741..999 CDD:285015 166/258 (64%)
SAM_1 1033..1092 CDD:278937 19/62 (31%)
SAM 1039..1092 CDD:197735 18/56 (32%)
EPHA2NP_004422.2 EphR_LBD_A2 28..201 CDD:198448 69/185 (37%)
fn3 330..418 CDD:365830 26/116 (22%)
fn3 438..516 CDD:365830 17/82 (21%)
EphA2_TM <556..608 CDD:373140 20/75 (27%)
PTKc_EphR_A2 607..875 CDD:133194 170/268 (63%)
SAM_EPH-A2 902..971 CDD:188942 20/75 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 399 1.000 Domainoid score I741
eggNOG 1 0.900 - - E2759_KOG0196
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 762 1.000 Inparanoid score I548
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D397694at33208
OrthoFinder 1 1.000 - - FOG0000086
OrthoInspector 1 1.000 - - otm42229
orthoMCL 1 0.900 - - OOG6_100189
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X82
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.830

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