DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eph and vab-1

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:NP_494807.1 Gene:vab-1 / 173794 WormBaseID:WBGene00006868 Length:1117 Species:Caenorhabditis elegans


Alignment Length:1121 Identity:376/1121 - (33%)
Similarity:533/1121 - (47%) Gaps:203/1121 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 RTILLIIISIHFKLAHADQVVLLDTTREAT-LEWTRYPYGPQAQTPGWVEESF-----TDFVKGI 124
            ::|.::::.....:..:.|.||.|.::..: |:|.:... ...:...|:||::     || .|..
 Worm    13 QSIFILVLQCLITIVTSHQEVLFDLSKVGSDLKWDQVSL-RHDRDDVWMEETWRNPAATD-EKHA 75

  Fly   125 NWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFD 189
            |.|:||.|:....|.:|||:|.||:..:|.|:|||:.|..|||..:. |..|||||||:...:|.
 Worm    76 NQRAYVTCNYDMINPSNWLFSHFIEVKTARRIYIELLFNTRDCDAYL-NPKSCKETFSVYLKQFK 139

  Fly   190 AATREPPPWQT-----------DSYRLIARIAAGEGRFNQNSDVDINTEVKSIAVNKKGVYFAFR 243
            .:.    |..|           |:::.|.|:|      ..||::...|....|..:.|.:..||.
 Worm   140 TSR----PGSTKIEKERFSEDIDNWKNIGRLA------RSNSNMTTETLGMEIDSDTKTIRIAFE 194

  Fly   244 DQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAE---PYETPTYLCK 305
            :||.|:|:|.||:||..|...|:...:|....||.:.|.:.:.||:|:.||.   |......||.
 Worm   195 EQGICLSLLNVKIYYRICDEFTDQLVYFRPQVTGPKETDMVRMNGSCIPNASKKIPGVDLIGLCM 259

  Fly   306 GDGKWTILTGGCRCKAGYE--PNYTNKTCTECPLGTFKSPEVTKCTPCPPNSNASKTGSPFCKCA 368
            ..|.....:|.|.|.:||.  .:.....|..||..|:|....:.|..||.||.:|:..|. |:|.
 Worm   260 STGSGIKTSGECVCDSGYSQIADSNGARCESCPTNTYKPKGQSLCKSCPSNSISSEAASS-CRCL 323

  Fly   369 SGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI 433
            :|::|..::...|||..||:.|..|....:..||..:||:.|          :|.....:|.|::
 Worm   324 NGYFRAEDELISMPCTQPPSRPIKLVANAITATSTRLSWNEP----------SSLGGRPEIWYEV 378

  Fly   434 KCN---ICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAV 495
            ||:   .|. .||..|.....:...:.:..|.|.:.||..:.|.|.||  .:|...|.:::::  
 Worm   379 KCSGRGECG-TVVMTPGDKKLSTRSVQINGLRPSSDYTFLVFAKNKVS--AQFPEFSEKNAVI-- 438

  Fly   496 SDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFP 560
                              :::|...|     |.|  ..|.:||:.|..:....:.|.   .||..
 Worm   439 ------------------DIRTRSEE-----EDV--PPVSHLRVDASQSDGITIAWS---VSDSD 475

  Fly   561 LEFYEVRWFPKVELDAINKSALNTKE---TKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQ 622
            :..:||...|.:    :.|....|:.   |....:||...|.|.|:||.:.:..:....:....:
 Worm   476 VSDFEVEVRPAI----VKKRTFETRHVNMTYTTFIGLNPETVYQFRVRIRDDLRWSQPISYQLGR 536

  Fly   623 TLQSVGSVYDDSVQIRFI--AGAIVTGVLFLVIFIIATVYFM--------RSKHQDDLD----KK 673
            .|.|..| .::..:.:|:  .|:.:..::.|::.:||....|        ..|...|||    .|
 Worm   537 GLMSSPS-SNEVEESQFLNQTGSALLIIIALILIVIAVALCMIVVQKKSKNRKQMSDLDVLDTYK 600

  Fly   674 STNHLPLPLDY--ASNEVNSMDTTPIVKKLHLNVTT-------PLFG---------------NS- 713
            ..:..|   ||  .|...:.....|......|..||       |.||               || 
 Worm   601 QDSMTP---DYHTTSRHHHHQGNLPATLHEQLRSTTKLNAPLIPSFGSPISQPPPYYGGVHPNSG 662

  Fly   714 --RSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRL--KIPPNFVQDID--- 771
              ::||||.|||||.||:.||..:|..|.:.|..:||||||||||.|.|  ..|......:.   
 Worm   663 KYKTYVDPTTYEDPYQALIEFTFDISPNDVFITQVIGGGEFGDVCLGGLSKNSPAAAKWSVSNTT 727

  Fly   772 -----------------VAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMI 819
                             |||||||.|||.||:.:|||||:|||||.|||||.|.||||.:.||||
 Worm   728 MGRGGGGGGYESEPYETVAIKTLKSGSSAKAKAEFLTEATIMGQFSHPNVIRLIGVVTSAEPVMI 792

  Fly   820 ITEYMENGSLDTFLRVNDGKFQTL---QLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLI 881
            :.|||.|||||.|||..|.:.:.:   ::..||.||||||.||:||.||||||||||||::.:|.
 Worm   793 VAEYMANGSLDQFLRNTDQRGEKVHWEKITEMLYGIASGMKYLTDMGYVHRDLAARNVLLDMELR 857

  Fly   882 CKIADFGLSREIENASDA----YTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYG 942
            ||||||||||.:.:...:    |||.||||||||||||||..||||.:|||||:|||:|||.|:|
 Worm   858 CKIADFGLSRGVRSEGSSVEPEYTTNGGKIPVRWTAPEAITHRKFTPSSDVWSFGVVIWEVCSFG 922

  Fly   943 ERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQP- 1006
            |||||:|:||.||..:..|||||.|||||..||::...||:.:|..||||..:::|......|| 
 Worm   923 ERPYWDWTNQKVISEVMIGYRLPPPMDCPMGLYRIAQWCWKMERHERPTFTQLLATFHKYILQPT 987

  Fly  1007 ---------------QSLLTTR--------PSPESDG---------------NHILDGQRGQNIF 1033
                           ||.|.|.        |:|.|..               ||:.......||.
 Worm   988 LIEHDPGELPRRVQSQSALNTYGSVNVGVVPTPPSSAAPMPSLDDFLRQIGLNHVYGQLVSNNIH 1052

  Fly  1034 ISTDLW-LEHIKMSRY 1048
            ..:||. ..|:.:..|
 Worm  1053 SVSDLANTSHLDLLAY 1068

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 63/191 (33%)
FN3 387..476 CDD:238020 22/91 (24%)
FN3 536..623 CDD:238020 19/89 (21%)
EphA2_TM 644..736 CDD:291255 35/130 (27%)
PTKc_EphR 736..1002 CDD:270629 163/294 (55%)
Pkinase_Tyr 741..999 CDD:285015 160/286 (56%)
SAM_1 1033..1092 CDD:278937 4/17 (24%)
SAM 1039..1092 CDD:197735 2/11 (18%)
vab-1NP_494807.1 EphR_LBD 32..211 CDD:198439 63/191 (33%)
FN3 342..423 CDD:238020 22/91 (24%)
FN3 450..531 CDD:238020 20/87 (23%)
EphA2_TM <642..687 CDD:291255 17/44 (39%)
PTKc_EphR 687..983 CDD:270629 163/295 (55%)
STYKc 692..979 CDD:214568 160/286 (56%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160166121
Domainoid 1 1.000 300 1.000 Domainoid score I774
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 508 1.000 Inparanoid score I721
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45908
OrthoDB 1 1.010 - - D397694at33208
OrthoFinder 1 1.000 - - FOG0000086
OrthoInspector 1 1.000 - - oto19989
orthoMCL 1 0.900 - - OOG6_100189
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2895
SonicParanoid 1 1.000 - - X82
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1211.840

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