Protein Alignment Eph and Met

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: NP_032617.2
• Gene: Met / 17295
• MGIID: 96969
• Length: 1379
• Species: Mus musculus
• Alignment Length: 1020
• Identity: 251/1020 - (24%)
• Similarity: 393/1020 - (38%)
• Gaps: 296/1020 - (29%)

  Fly   206 IARIAAGEGRF----------------------------------NQNSDVDINT--EVKSIAVN 234
            ||.:...||||                                  |||....:.|  ::..|.:|
Mouse   451 IANLGTSEGRFMQVVLSRTAHLTPHVNFLLDSHPVSPEVIVEHPSNQNGYTLVVTGKKITKIPLN 515

  Fly   235 KKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAHFNETPTG---REITIIEKQNGTCVDNAEP 296
            ..|... |:....|:|.    .|:|.|.........|:|.|:|   :||.:      ..|....|
Mouse   516 GLGCGH-FQSCSQCLSA----PYFIQCGWCHNQCVRFDECPSGTWTQEICL------PAVYKVFP 569

  Fly   297 YETPTYLCKGDGKWTILTGG-----CRCKAGYEPN-----------YTNKTCTECPLGTFKSPEV 345
            ...|            |.||     |....|:..|           ..|::||   |...:|...
Mouse   570 TSAP------------LEGGTVLTICGWDFGFRKNNKFDLRKTKVLLGNESCT---LTLSESTTN 619

  Fly   346 T-KCTPCP------------PNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLF 397
            | |||..|            .||..:...|.|.      |..|......|.|.|.|..|.|||
Mouse   620 TLKCTVGPAMSEHFNVSVIISNSRETTQYSAFS------YVDPVITSISPRYGPQAGGTLLTL-- 676

  Fly   398 VDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTFNE----TKITL 458
               |...:: |..:::.|...:|.:....||.:  ::|        |.|:..|.:|    .||.|
Mouse   677 ---TGKYLN-SGNSRHISIGGKTCTLKSVSDSI--LEC--------YTPAQTTSDEFPVKLKIDL 727

  Fly   459 TNLE---------PVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNE 514
            .|.|         ||   ..:||...|..        |..|::..:.. ..::.||..:.:|::|
Mouse   728 ANRETSSFSYREDPV---VYEIHPTKSFI--------SGGSTITGIGK-TLNSVSLPKLVIDVHE 780

  Fly   515 V---------KTGQAEIVFTTESVL--------LSTVFNLRILAITNKDADLEW---------DK 553
            |         ....:||:..|...|        |.|.....:..|.:|..||.:         :|
Mouse   781 VGVNYTVACQHRSNSEIICCTTPSLKQLGLQLPLKTKAFFLLDGILSKHFDLTYVHNPVFEPFEK 845

  Fly   554 PVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQ-----------VRCK 607
            ||......|       ..||:...|   ::.:..|..::      :.|.|           |.|.
Mouse   846 PVMISIGNE-------NVVEIKGNN---IDPEAVKGEVL------KVGNQSCESLHWHSGAVLCT 894

  Fly   608 TNNGFGSYSNMIYAQTLQSVGSVYDDSVQI---RFIAGAIVTGVLFLVIFIIATVYFM---RSKH 666
            ..:.....::.:..:..|:|.|.....|.:   :..||.|:..|...|:.::.:..|:   :.||
Mouse   895 VPSDLLKLNSELNIEWKQAVSSTVLGKVIVQPDQNFAGLIIGAVSISVVVLLLSGLFLWMRKRKH 959

  Fly   667 QD---------------DLDK-KSTNHLPLPLDYASNE-------------VNS----------- 691
            :|               .||: .|...:....:..|||             .||
Mouse   960 KDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGACRQVQY 1024

  Fly   692 --MDTTPIVKKLHLNVTTPLFGNS----RSYVDP-------HTYEDPNQAIREFAREIDANYITI 743
              .|.:||:.....::::||..|:    .|.::|       |....|:..|..|
Mouse  1025 PLTDLSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHF----------- 1078

  Fly   744 EAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQ 808
            ..:||.|.||.|..|.|.  .|..:.|..|:|:|...:..:....||||..||..|.||||:.|.
Mouse  1079 NEVIGRGHFGCVYHGTLL--DNDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSLL 1141

  Fly   809 GVVTRS--NPVMIITEYMENGSLDTFLRVNDGKFQTLQ-LIVMLRGIASGMSYLSDMNYVHRDLA 870
            |:..||  :| :::..||::|.|..|:| |:....|:: ||.....:|.||.||:...:||||||
Mouse  1142 GICLRSEGSP-LVVLPYMKHGDLRNFIR-NETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLA 1204

  Fly   871 ARNVLVNAQLICKIADFGLSREIENAS--DAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGV 933
            |||.:::.:...|:|||||:|::.:..  ..:...|.|:||:|.|.|::..:|||:.|||||:||
Mouse  1205 ARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGV 1269

  Fly   934 VLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVST 998
            :|||:|:.|..||.:.:..|:...:.:|.||..|..||:|||::||.||..:...||:|:.:||.
Mouse  1270 LLWELMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYCPDALYEVMLKCWHPKAEMRPSFSELVSR 1334

  Fly   999 LDNL----------------------ARQPQSLLTTRPSPESDGN 1021
            :.::                      |..| |||.::.:.:.:||
Mouse  1335 ISSIFSTFIGEHYVHVNATYVNVKCVAPYP-SLLPSQDNIDGEGN 1378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	17/89 (19%)
		FN3	387..476	CDD:238020	25/101 (25%)
		FN3	536..623	CDD:238020	16/106 (15%)
		EphA2_TM	640..738	CDD:464211	29/153 (19%)
		PTKc_EphR	736..1002	CDD:270629	103/270 (38%)
		SAM_1	1029..1092	CDD:425739
Met	NP_032617.2	Sema	25..515	CDD:472829	11/63 (17%)
		PSI	518..560	CDD:214655	12/46 (26%)
		IPT_plexin_repeat1	562..655	CDD:238585	24/113 (21%)
		IPT_plexin_repeat2	656..739	CDD:238584	25/98 (26%)
		IPT	741..836	CDD:472823	22/106 (21%)
		IPT_PCSR	838..917	CDD:238337	14/94 (15%)
		PTKc_Met_Ron	1080..1341	CDD:270649	103/264 (39%)
		Interaction with RANBP9. /evidence=ECO:0000250	1210..1379		57/170 (34%)
		Interaction with MUC20. /evidence=ECO:0000250	1318..1357		6/38 (16%)