DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and Epha7

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_599158.1	Gene:	Epha7 / 171287	RGDID:	70957	Length:	998	Species:	Rattus norvegicus

Alignment Length:	1052	Identity:	441/1052 - (41%)
Similarity:	604/1052 - (57%)	Gaps:	150/1052 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 ADQVVLLDTTREAT-LEWTRYPYGPQAQTPGW-----VEESFTDFVKGINWRSYVVCDVAYHNVN 140
            |.:|:|||:..:.| |||...|      ..||     ::|::|..      |:|.||.|...|.|
  Rat    30 AKEVLLLDSKAQQTELEWISSP------PSGWEEISGLDENYTPI------RTYQVCQVMEPNQN 82

  Fly   141 NWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAAT----REPPPWQTD 201
            |||.:.:|.:|:|.|:::|::||:|||:..||...:|||||:|.:||.|..|    ||      :
  Rat    83 NWLRTNWISKGNAQRIFVELKFTLRDCNSLPGVLGTCKETFNLYYYETDYDTGRNIRE------N 141

  Fly   202 SYRLIARIAAGEGRFNQNS----DVDINTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITC 261
            .|..|..|||.|. |.|..    .:.:||||:.|. ::|||.|.||:|.||||::::|||||..|
  Rat   142 LYVKIDTIAADES-FTQGDLGERKMKLNTEVREIGPLSKKGFYLAFQDVGACIALVSVKVYYKKC 205

  Fly   262 PAVTENFAHFNETPTGREITIIEKQNGTCVDNA--EPYETPTYLCKGDGKWTILTGGCRCKAGYE 324
            .::.||.|.|.:|.||.|.:.:.:..||||.:|  |...:|...|..:|:|.:..|.|.|||||:
  Rat   206 WSIIENLAVFPDTVTGSEFSSLVEVRGTCVSSAEEEAENSPRMHCSAEGEWLVPIGKCICKAGYQ 270

  Fly   325 PNYTNKTCTECPLGTFK-SPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPA 388
            ..  ..||..|....:| |.:..:|:.||.:|.:.:.||..|:|..|:||.|:|..::.|..||:
  Rat   271 QK--GDTCEPCGRRFYKSSSQDLQCSRCPTHSFSDREGSSRCECEDGYYRAPSDPPYVACTRPPS 333

  Fly   389 APTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICS----------PNVV 443
            ||.|| :..::||:..:.||.||.|..          .:|:.|:|.|..||          .|:.
  Rat   334 APQNL-IFNINQTTVSLEWSPPADNGG----------RNDVTYRILCKRCSWEQGECVPCGSNIG 387

  Fly   444 YNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNI 508
            |.|......:..:|:.:|.....||.::.|:|.||.::..:|             :|:..|
  Rat   388 YMPQQTGLEDNYVTVMDLLAHANYTFEVEAVNGVSDLSRSQR-------------LFAAVS---- 435

  Fly   509 PLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVE 573
                  :.||||      ....:|.|...|:|   .:..:|.|.:|...:..:..||::::.|.:
  Rat   436 ------ITTGQA------APSQVSGVMKERVL---QRSVELSWQEPEHPNGVITEYEIKYYEKDQ 485

  Fly   574 LDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVG-------SVY 631
            .:. ..|.|.||.|.|.|..|...|.|.||:|..|..|:|:||..:...||:...       :|.
  Rat   486 RER-TYSTLKTKSTSASINNLKPGTVYVFQIRAFTAAGYGNYSPRLDVATLEEASGKMFEATAVS 549

  Fly   632 DDSVQIRFIAGAIVTGVLFLVI----FIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSM 692
            .:...:..||...|.|.:.||.    |||...:...||...:.|::...|...|
  Rat   550 SEQNPVIIIAVVAVAGTIILVFMVFGFIIGRRHCGYSKADQEGDEELYFHFKFP----------- 603

  Fly   693 DTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCR 757
                               .:::|:||.||||||:|:.:||:|:||:.|.||.:||.||||:||.
  Rat   604 -------------------GTKTYIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCS 649

  Fly   758 GRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITE 822
            ||||:|..  :|:.|||||||.|.:||.|.|||.|||||||||||||::|:|||||..||||:.|
  Rat   650 GRLKLPGK--RDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIE 712

  Fly   823 YMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADF 887
            :||||:||.|||.:||:|..:||:.||||||:||.||:||.||||||||||:|||:.|:||::||
  Rat   713 FMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDF 777

  Fly   888 GLSREIENASDA-YTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSN 951
            ||||.||:..:| |||.||||||||||||||.:|||||||||||||:|:||||||||||||:.||
  Rat   778 GLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSN 842

  Fly   952 QDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLT----- 1011
            |||||:||:|||||||||||..|:|||||||||:|..||.|..||..||.:.|.|.||.|
  Rat   843 QDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKMIRNPSSLKTPLGTC 907

  Fly  1012 TRP-SPESDGNHILDGQRGQ-NIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDM 1074
            :|| ||      :||..... ..|.|...||:.|||.||..:|..|...:.:.::|:|...:..:
  Rat   908 SRPISP------LLDQSTPDFTAFCSVGEWLQAIKMERYKDNFTAAGYNSLESVARMTIDDVMSL 966

  Fly  1075 GITLVGHQKKIL 1086
            |||||||||||:
  Rat   967 GITLVGHQKKIM 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	76/189 (40%)
		FN3	387..476	CDD:238020	26/98 (27%)
		FN3	536..623	CDD:238020	26/86 (30%)
		EphA2_TM	644..736	CDD:291255	24/95 (25%)
		PTKc_EphR	736..1002	CDD:270629	189/266 (71%)
		Pkinase_Tyr	741..999	CDD:285015	185/258 (72%)
		SAM_1	1033..1092	CDD:278937	24/54 (44%)
		SAM	1039..1092	CDD:197735	22/48 (46%)
Epha7	NP_599158.1	EphR_LBD_A7	30..206	CDD:198453	77/194 (40%)
		FN3	332..438	CDD:238020	32/139 (23%)
		FN3	443..534	CDD:238020	28/94 (30%)
		EphA2_TM	565..630	CDD:405290	24/94 (26%)
		PTKc_EphR_A	628..894	CDD:270651	189/267 (71%)
		SAM_EPH-A7	919..988	CDD:188947	24/60 (40%)
		PDZ-binding. /evidence=ECO:0000255	996..998
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	399	1.000	Domainoid score	I718
eggNOG	1	0.900	-	-		E2759_KOG0196
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	763	1.000	Inparanoid score	I521
OMA	1	1.010	-	-		QHG45908
OrthoDB	1	1.010	-	-		D397694at33208
OrthoFinder	1	1.000	-	-		FOG0000086
OrthoInspector	1	1.000	-	-		otm46382
orthoMCL	1	0.900	-	-		OOG6_100189
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X82
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880