Protein Alignment Eph and Ltk

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: NP_976220.2
• Gene: Ltk / 17005
• MGIID: 96840
• Length: 888
• Species: Mus musculus
• Alignment Length: 315
• Identity: 117/315 - (37%)
• Similarity: 172/315 - (54%)
• Gaps: 23/315 - (7%)

  Fly   735 EIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQF 799
            |:....:|:...:|.|.||:|..|.:...|.....:.||||||....|.:...|||.||.|:.:|
Mouse   500 EVSPANVTLLRALGHGAFGEVYEGLVTGLPGDSSPLPVAIKTLPELCSHQDELDFLMEALIISKF 564

  Fly   800 DHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFL---RVNDGKFQTL---QLIVMLRGIASGMSY 858
            .|.|::...|:..||.|.:|:.|.|..|.:.:||   |.:.|:...|   .|:.:.:.||.|..|
Mouse   565 SHQNIVRCVGLSFRSAPRLILLELMSGGDMKSFLRHSRPHPGQLAPLTMQDLLQLAQDIAQGCHY 629

  Fly   859 LSDMNYVHRDLAARNVLVN---AQLICKIADFGLSREIENASDAYTTRGGK--IPVRWTAPEAIA 918
            |.:.:::|||:||||.|::   |..:.||.|||::|:|..||  |..:||:  :||:|..|||:.
Mouse   630 LEENHFIHRDIAARNCLLSCSGASRVAKIGDFGMARDIYQAS--YYRKGGRTLLPVKWMPPEALL 692

  Fly   919 FRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQ 983
            ...|||.:|.||:||:|||:.|.|..||...:||:|:..|..|.|:..|.:||..:|::|..|||
Mouse   693 EGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMDPPRNCPGPVYRIMTQCWQ 757

  Fly   984 KQRTHRPTFASIVSTLDNLARQPQSL---LTTRPSP---ESD----GNHILDGQR 1028
            .|...||.|.||:..:....:.|..|   |...|.|   |.:    ||..|:|.|
Mouse   758 HQPELRPDFGSILERIQYCTQDPDVLNSPLPVEPGPILEEEEASRLGNRSLEGLR 812

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020
		FN3	536..623	CDD:238020
		EphA2_TM	640..738	CDD:464211	1/2 (50%)
		PTKc_EphR	736..1002	CDD:270629	105/276 (38%)
		SAM_1	1029..1092	CDD:425739	117/315 (37%)
Ltk	NP_976220.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	226..294
		PTKc_ALK_LTK	499..775	CDD:270632	106/276 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..888