DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and Insr

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001316985.1	Gene:	Insr / 16337	MGIID:	96575	Length:	1384	Species:	Mus musculus

Alignment Length:	1021	Identity:	250/1021 - (24%)
Similarity:	383/1021 - (37%)	Gaps:	308/1021 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 GNALSCKE---TFSLLFYEFD-AATREPPPWQTDSYRLIARIAAGEGRFNQNSDVDINTEVKSIA 232
            |:..||:.   .||.:...|| ...|..|.|..|
Mouse   490 GDQASCENELLKFSFIRTSFDKILLRWEPYWPPD------------------------------- 523

  Fly   233 VNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPY 297
                     |||      :|...::|...|  .:|...|:    |::  .....:.|.||...|.
Mouse   524 ---------FRD------LLGFMLFYKEAP--YQNVTEFD----GQD--ACGSNSWTVVDIDPPQ 565

  Fly   298 ET----------PTYLCKGDGKWTIL---------------TGGCRCKAGY-EPNYTNKTCTECP 336
            .:          |.:|.:|...||..               |.|.:....| :.:.||
Mouse   566 RSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATN------- 623

  Fly   337 LGTFKSPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPT-NLTLLFV-- 398
                  |.|    |..|.|.::.:.....|                 :.||:.|. |:|...|
Mouse   624 ------PSV----PLDPISVSNSSSQIILK-----------------WKPPSDPNGNITHYLVYW 661

  Fly   399 ---DQTSAII--------------SWSAPAKNESFSSETNSKIYHSDIVY---KIKCNICSPNVV 443
               .:.|.:.              :||.|     |.|:.:.|  |:...|   ..:|..|
Mouse   662 ERQAEDSELFELDYCLKGLKLPSRTWSPP-----FESDDSQK--HNQSEYDDSASECCSC----- 714

  Fly   444 YNPSTDTFNETKITLTNLEPVT---TYTVQIHAI-------NSVSHINEFKRHSNESSLVAVSDI 498
              |.||:     ..|..||..:   |:...:|.:       :|.:...:.:......||..|.::
Mouse   715 --PKTDS-----QILKELEESSFRKTFEDYLHNVVFVPRKTSSGNGAEDSRPSRKRRSLEEVGNV 772

  Fly   499 VFSNTSLLNIP-LDLNEVKTGQA-----EIVFTTESVLLS-----TVFNLRILAITNKDAD---- 548
            ..:..:|.:.| :....|.|.|.     |.|...||:::|     |.:.:.:.|......|
Mouse   773 TATTLTLPDFPNVSSTIVPTSQEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPDERCS 837

  Fly   549 ---------------------------------LEWDKPVQSDFPLEFYEV--RWFPKVELDAIN 578
                                             |.|.:|.:.:..:..|||  |.:...||....
Mouse   838 VAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCV 902

  Fly   579 KSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQI-RFIAG 642
            .......|....:.||... .|..:||..:..|.||::...|...        .|.:.: ..||.
Mouse   903 SRKHFALERGCRLRGLSPG-NYSVRVRATSLAGNGSWTEPTYFYV--------TDYLDVPSNIAK 958

  Fly   643 AIVTGVLFLVIF--IIATVY-FMRSKHQDDLDKKSTNHLPLPLDYASNE---VNSMDTTPIVKKL 701
            .|:..::|:.:|  :|.::| |:|.:..|.         |:...|||:.   :::.|..|
Mouse   959 IIIGPLIFVFLFSVVIGSIYLFLRKRQPDG---------PMGPLYASSNPEYLSASDVFP----- 1009

  Fly   702 HLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNF 766
                       |..|| |..:|.|.:.            ||:...:|.|.||.|..|..|.....
Mouse  1010 -----------SSVYV-PDEWEVPREK------------ITLLRELGQGSFGMVYEGNAKDIIKG 1050

  Fly   767 VQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDT 831
            ..:..||:||:...:|.:.|.:||.|||:|..|...:|:.|.|||::..|.:::.|.|.:|.|.:
Mouse  1051 EAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKS 1115

  Fly   832 FLRV-------NDGK-FQTLQ-LIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADF 887
            .||.       |.|: ..||| :|.|...||.||:||:...:|||||||||.:|......||.||
Mouse  1116 HLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDF 1180

  Fly   888 GLSREIENASDAYTTRGGK--IPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWS 950
            |::|:|....  |..:|||  :||||.:||::....||::||:||:||||||:.|..|:||...|
Mouse  1181 GMTRDIYETD--YYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLS 1243

  Fly   951 NQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTL-DNLARQPQSLLTTRP 1014
            |:.|:|.:..|..|..|.:|||.|..||..|||.....||||..||:.| |:|          .|
Mouse  1244 NEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDDL----------HP 1298

  Fly  1015 S-PE-----SDGNHILDGQRGQNIFISTDLWLEHIKMSRYCHHFKE 1054
            | ||     |:.|...:.:..:..|..    :|::.:.|..|..:|
Mouse  1299 SFPEVSFFYSEENKAPESEELEMEFED----MENVPLDRSSHCQRE 1340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	16/91 (18%)
		FN3	387..476	CDD:238020	24/121 (20%)
		FN3	536..623	CDD:238020	21/125 (17%)
		EphA2_TM	644..736	CDD:291255	20/97 (21%)
		PTKc_EphR	736..1002	CDD:270629	114/277 (41%)
		Pkinase_Tyr	741..999	CDD:285015	112/268 (42%)
		SAM_1	1033..1092	CDD:278937	5/22 (23%)
		SAM	1039..1092	CDD:197735	4/16 (25%)
Insr	NP_001316985.1	Recep_L_domain	52..164	CDD:279382
		Furin-like	179..337	CDD:279142
		FU	234..281	CDD:238021
		Recep_L_domain	359..472	CDD:279382
		FN3	624..>667	CDD:238020	12/63 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..709		7/27 (26%)
		Insulin-binding. /evidence=ECO:0000250	735..743		1/7 (14%)
		FN3	869..946	CDD:238020	19/77 (25%)
		Important for interaction with IRS1, SHC1 and STAT5B. /evidence=ECO:0000250	998..1001		0/2 (0%)
		PTKc_InsR	1018..1305	CDD:133192	121/310 (39%)
		Pkinase_Tyr	1025..1292	CDD:285015	112/268 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1361..1384
		PIK3R1 binding. /evidence=ECO:0000250	1363..1366
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910