Protein Alignment Eph and Igf1r

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: XP_006540704.1
• Gene: Igf1r / 16001
• MGIID: 96433
• Length: 1401
• Species: Mus musculus
• Alignment Length: 835
• Identity: 200/835 - (23%)
• Similarity: 332/835 - (39%)
• Gaps: 247/835 - (29%)

  Fly   323 YEPNYTNKTCTECPL-----GTFKSPEVTK-------------CTPCP---PNSNASKTGSPFCK 366
            |..||.:| ..:.|:     ||....|||:             |..||   ....|.|..:.:.|
Mouse   659 YRHNYCSK-ADKIPIRKYADGTIDVEEVTENPKTEVCGGDKGPCCACPKTEAEKQAEKEEAEYRK 722

  Fly   367 CASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSE---TNSKIYHSD 428
            ....|.       |...:.|........::.|..|    :.|:.::|.:.:..   |:.:.:.::
Mouse   723 VFENFL-------HNSIFVPRPERRRRDVMQVANT----TMSSRSRNTTVADTYNITDPEEFETE 776

  Fly   429 IVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLV 493
            ..:            :....|  |:.:..::||.|.|.|.:.||:.|          |..|....
Mouse   777 YPF------------FESRVD--NKERTVISNLRPFTLYRIDIHSCN----------HEAEKLGC 817

  Fly   494 AVSDIVFSNTSLLNIPLDLNEVKTGQAEI--VFTTESVLLSTVFNLRILAITNKDADLEWDKPVQ 556
            :.|:.||:.|    :|.:      |..:|  ..|.|....:::|             |:|.:|..
Mouse   818 SASNFVFART----MPAE------GADDIPGPVTWEPRPENSIF-------------LKWPEPEN 859

  Fly   557 SDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYA 621
            .:..:..||:::..:|             |.:...|...|..:||.....:.|.  |:|:..|.|
Mouse   860 PNGLILMYEIKYGSQV-------------EDQRECVSRQEYRKYGGAKLNRLNP--GNYTARIQA 909

  Fly   622 QTLQSVGS-------------VYDDSVQIRF---IAGAIVTGVLFLVIFIIATVYFMRSKHQDDL 670
            .:|...||             .|::.:.:..   :|..::.|.|.:::::     |.|.::...|
Mouse   910 TSLSGNGSWTDPVFFYVPAKTTYENFMHLIIALPVAILLIVGGLVIMLYV-----FHRKRNNSRL 969

  Fly   671 DKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFARE 735
                           .|.|           |:.:|....|..:..||       |::  .|.|||
Mouse   970 ---------------GNGV-----------LYASVNPEYFSAADVYV-------PDE--WEVARE 999

  Fly   736 IDANYITIEAIIGGGEFG----DVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIM 796
                .||:...:|.|.||    .|.:|.:|..|    :..|||||:...:|.:.|.:||.|||:|
Mouse  1000 ----KITMNRELGQGSFGMVYEGVAKGVVKDEP----ETRVAIKTVNEAASMRERIEFLNEASVM 1056

  Fly   797 GQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRV---------------NDGKFQTL--- 843
            .:|:..:|:.|.|||::..|.::|.|.|..|.|.::||.               ..|..:||
Mouse  1057 KEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVEPRLSWNSLRRPGWPRTLRDS 1121

  Fly   844 -----------------------QLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIA 885
                                   ::|.|...||.||:||:...:|||||||||.:|......||.
Mouse  1122 LASVSQVLALKQNNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIG 1186

  Fly   886 DFGLSREIENASDAYTTRGGK--IPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWN 948
            |||::|:|....  |..:|||  :||||.:||::....||:.|||||:||||||:.:..|:||..
Mouse  1187 DFGMTRDIYETD--YYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQG 1249

  Fly   949 WSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTL-------------- 999
            .||:.|::.:.:|..|..|.:||:.|::||..|||.....||:|..|:.::
Mouse  1250 LSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSIKDEMEPSFQEVSFY 1314

  Fly  1000 ----------DNLARQPQSL----------LTTRPSPESDGNHILDGQRGQNIFI 1034
                      :.|..:|:::          ..:.|.||....|..:...|..:.:
Mouse  1315 YSEENKPPEPEELEMEPENMESVPLDPSASSASLPLPERHSGHKAENGPGPGVLV 1369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	14/91 (15%)
		FN3	536..623	CDD:238020	16/86 (19%)
		EphA2_TM	640..738	CDD:464211	18/97 (19%)
		PTKc_EphR	736..1002	CDD:270629	109/336 (32%)
		SAM_1	1029..1092	CDD:425739	1/6 (17%)
Igf1r	XP_006540704.1	Recep_L_domain	51..161	CDD:460032
		Furin-like	175..330	CDD:395614
		Recep_L_domain	353..468	CDD:460032
		FN3	494..607	CDD:238020
		FN3	612..>656	CDD:238020
		FN3	837..926	CDD:238020	22/116 (19%)
		PTKc_InsR_like	994..1302	CDD:173625	113/317 (36%)