DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eph and Ephb6

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:XP_030111004.1 Gene:Ephb6 / 13848 MGIID:1096338 Length:1078 Species:Mus musculus


Alignment Length:1152 Identity:366/1152 - (31%)
Similarity:564/1152 - (48%) Gaps:211/1152 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 SQIVSRMSLLRTILLIIISIHFKLAHADQVVLLDTTREAT-LEWTRYPYGPQAQTPGWVEESFTD 119
            |::|:.|.....:|::..|:     .|.:.||||||.|.: :.|..||.|      ||.|.|..|
Mouse    11 SRVVAGMVCSLWLLVLGSSV-----LALEEVLLDTTGETSEIGWLTYPPG------GWDEVSVLD 64

  Fly   120 FVKGINWRSYVVCDVA----YHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKET 180
            ..:.:. |::..|.||    ....:|||.:.|::|..|.|.:|.:.|::|.||....:..:|:||
Mouse    65 DQRRLT-RTFEACHVAGLPPGSGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRET 128

  Fly   181 FSLLFYEFDAATREP------PPWQTDSYRLIARIAAGEG---------------RFNQNSDVDI 224
            |:|.:.:.|    ||      ..|....:..:..|||.|.               |..|...:.:
Mouse   129 FTLYYRQAD----EPDGPDSIAAWHLKRWTKVDTIAADESFPASSSSSSWAVGPHRTGQRVGLQL 189

  Fly   225 NTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAHFNET-PTGREITIIEKQN 287
            |.:.:|.. :.::|.|.||:|.|||::::|||::..|||:|...||.|.|| .:|.....:....
Mouse   190 NVKERSFGPLTQRGFYVAFQDTGACLALVAVKLFSYTCPSVLRAFASFPETQASGAGGASLVAAV 254

  Fly   288 GTCVDNAEPYE----------TPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKS 342
            ||||.:|||.|          .|...|.|:|:|.:..|||||:.|::|...:|.|..||.|::|:
Mouse   255 GTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGRWMVAVGGCRCQPGHQPARGDKLCQACPEGSYKA 319

  Fly   343 -----PEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTS 402
                 |    |:|||..|::....:|.|.|..||||..:|....||..||:||..  |.|..|.|
Mouse   320 LAGNVP----CSPCPARSHSPDPAAPVCPCLQGFYRASSDPPEAPCTGPPSAPRE--LWFEVQGS 378

  Fly   403 AI-ISWSAPAKNESFSSETNSKIYHSDIVYKI---------------KCNICSPNVVYNPSTDTF 451
            |: :.|..|       .|...:   .|:::.:               .|..|...|.::|.....
Mouse   379 ALMLHWRLP-------QELGGR---GDLLFNVVCKECGGHGEPSSGGMCRRCRDEVHFDPRQRGL 433

  Fly   452 NETKITLTNLEPVTTYTVQIHAINSVSH----------INEFKRHSNESSLVAVSDIVFSNTS-L 505
            .|:::.:..|.....|.:::.|:|.||.          ||....|..|....::....||::. |
Mouse   434 TESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEGELFSFSLRTACFSSSDPL 498

  Fly   506 LNIP---------LDLNEVKT-------------------GQAEIVFTTESVL--LSTVFNLRIL 540
            ..:|         |.||.:.:                   ....:|.:...|:  :|...|    
Mouse   499 FPMPDFQPACIRHLILNSIPSTLGCCCLQRLQTPPPNNNPPPCTLVPSAVPVMHQVSRAAN---- 559

  Fly   541 AITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVR 605
            :||     :.|.:|.|::..:..|::|::.:.| |..:...:.::...|.:..|.....||||||
Mouse   560 SIT-----VSWPQPEQTNGNILDYQLRYYDQAE-DESHSFTMTSETNTATVTRLSPGHIYGFQVR 618

  Fly   606 CKTNNGFGSYSNMIYAQTLQ--SVGSVYDDSVQIRFIAGAIVTGVLFLVI--FIIATVYFMRSKH 666
            .:|..|.|.|...:|.|||.  .:.|...:.:.:  :.|:|:..:.||::  ..:..|.|.|.  
Mouse   619 ARTAAGHGPYGGKVYFQTLPQGELSSQLPEKLSL--VIGSILGALAFLLLAAITVLAVIFQRK-- 679

  Fly   667 QDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIRE 731
                 ::.|.:......|:|                     |..| .:.|:||.||:||.|||||
Mouse   680 -----RRGTGYTEQLQQYSS---------------------PGLG-VKYYIDPSTYDDPCQAIRE 717

  Fly   732 FAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIM 796
            .|||:|..||.||.:||.|.||:|.||||:  |...::..|||:.|..|.:|..:..||..|:::
Mouse   718 LAREVDPTYIKIEEVIGAGSFGEVRRGRLQ--PRGRREQAVAIQALWAGGAESLKMTFLGRAALL 780

  Fly   797 GQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSD 861
            |||.|||::.|:||||:|.|||::||.||.|.||:|||..:|:|.:|||:.|.||:|:.|.|||.
Mouse   781 GQFQHPNILRLEGVVTKSRPVMVLTELMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSS 845

  Fly   862 MNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSAS 926
            ..:|||.|:||:||||:.|:||:|..|           ::.:|....:||.|||.|...|:|::|
Mouse   846 FAFVHRALSARSVLVNSHLVCKVARLG-----------HSPQGSSSLLRWAAPEVITHGKYTTSS 899

  Fly   927 DVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPT 991
            ||||:|:::||||||||||||:.:.|:|:.:||:.:|||.|..||..|:.||||.|||.|..||.
Mouse   900 DVWSFGILMWEVMSYGERPYWDMNEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPH 964

  Fly   992 FASIVSTLDNLARQPQSLLTTRPSPESDGNHILDGQRGQNIFI-----------STDLWLEHIKM 1045
            |..:|:..|.:.|:|.:|       :::|.   .|.|.....:           |...||..|.:
Mouse   965 FDQLVAAFDKMIRKPDTL-------QAEGG---SGDRPSQALLNPVALDFPCLDSPQAWLSAIGL 1019

  Fly  1046 SRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKILHQARQL 1092
            ..|..:|.:..|.....:::|:.:.|..:||||.|||||:||..:.|
Mouse  1020 ECYQDNFSKFGLSTFSDVAQLSLEDLPGLGITLAGHQKKLLHNIQLL 1066

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 60/201 (30%)
FN3 387..476 CDD:238020 20/104 (19%)
FN3 536..623 CDD:238020 23/86 (27%)
EphA2_TM 644..736 CDD:291255 25/93 (27%)
PTKc_EphR 736..1002 CDD:270629 129/265 (49%)
Pkinase_Tyr 741..999 CDD:285015 126/257 (49%)
SAM_1 1033..1092 CDD:278937 20/69 (29%)
SAM 1039..1092 CDD:197735 19/52 (37%)
Ephb6XP_030111004.1 EphR_LBD_B6 34..226 CDD:198443 60/202 (30%)
Ephrin_rec_like 305..340 CDD:311571 12/38 (32%)
fn3 366..464 CDD:365830 22/109 (20%)
FN3 545..636 CDD:238020 25/100 (25%)
EphA2_TM 669..722 CDD:373140 22/81 (27%)
PKc_like 722..976 CDD:389743 129/266 (48%)
SAM_EPH-B6 1002..1070 CDD:188954 21/65 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 121 1.000 Domainoid score I5665
eggNOG 1 0.900 - - E2759_KOG0196
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 760 1.000 Inparanoid score I548
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D397694at33208
OrthoFinder 1 1.000 - - FOG0000086
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100189
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X82
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
109.770

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