DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eph and Ephb3

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:XP_006521851.1 Gene:Ephb3 / 13845 MGIID:104770 Length:1048 Species:Mus musculus


Alignment Length:1030 Identity:417/1030 - (40%)
Similarity:581/1030 - (56%) Gaps:118/1030 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 LLDT---TREATLEWTRYPYGPQAQTPGWVEESFTDFVKGIN-WRSYVVCDVAYHNVNNWLWSPF 147
            |:||   |.|  |.||.:|      ..||.|.|..|  :.:| .|:|.||:|...:.||||.:.|
Mouse    34 LMDTKWVTSE--LAWTSHP------ESGWEEVSGYD--EAMNPIRTYQVCNVRESSQNNWLRTGF 88

  Fly   148 IDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDA--ATREPPPWQTDSYRLIARIA 210
            |.|....|:|:|::||:|||:..|....||||||:|.:||.|:  |:...|.|..:.|..:..||
Mouse    89 IWRREVQRVYVELKFTVRDCNSIPNIPGSCKETFNLFYYEADSDVASASSPFWMENPYVKVDTIA 153

  Fly   211 AGEGRFNQNSDVDINTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAHFNET 274
            ..|. |::.....:||:|:|.. ::|.|.|.||:|||||:|:::|:.:|..|.:.|..||.|.||
Mouse   154 PDES-FSRLDAGRVNTKVRSFGPLSKAGFYLAFQDQGACMSLISVRAFYKKCASTTAGFALFPET 217

  Fly   275 PTGREITIIEKQNGTCVDNAEPYETPTYL-CKGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLG 338
            .||.|.|.:....|||:.||.....|..| |.|||:|.:..|.|.|..|:||......|..||.|
Mouse   218 LTGAEPTSLVIAPGTCIANAVEVSVPLKLYCNGDGEWMVPVGACTCATGHEPAAKESQCRACPPG 282

  Fly   339 TFKSPE-VTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTS 402
            ::|:.: ...|.||||||..:...:..|.|.:.|||..:|.....|.:.|:.|..: :..|::||
Mouse   283 SYKAKQGEGPCLPCPPNSRTTSPAASICTCHNNFYRADSDSADSACTTVPSPPRGV-ISNVNETS 346

  Fly   403 AIISWSAPAKNESFSSETNSKIYHSDIVYKI---------------KCNICSPNVVYNPSTDTFN 452
            .|:.||.|.....          ..|::|.:               .|:.|..||.:.|......
Mouse   347 LILEWSEPRDLGG----------RDDLLYNVICKKCRGSSGAGGPATCSRCDDNVEFVPRQLGLT 401

  Fly   453 ETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKT 517
            |.::.:::|...|.||.::.|:|.|         |.:|.|                       ..
Mouse   402 ERRVHISHLLAHTRYTFEVQAVNGV---------SGKSPL-----------------------PP 434

  Fly   518 GQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSAL 582
            ..|.:..||.....|.|..|.:.:.:.....|.|..|.:.:..:..||:::|.|.:..|   |.:
Mouse   435 RYAAVNITTNQAAPSEVPTLHLHSSSGSSLTLSWAPPERPNGVILDYEMKYFEKSKGIA---STV 496

  Fly   583 NTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGS-VYDDSVQIRFIAGAIVT 646
            .:::....:.||..:..|..|||.:|..|:|.||:....:|....|| ......|:..|.|:.|.
Mouse   497 TSQKNSVQLDGLQPDARYVVQVRARTVAGYGQYSHPAEFETTSERGSGAQQLQEQLPLIVGSTVA 561

  Fly   647 GVLFL-VIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLF 710
            |.:|: |:.:||.|...:.:|..|.:                         ..:||...:...: 
Mouse   562 GFVFMVVVVVIALVCLRKQRHGPDAE-------------------------YTEKLQQYIAPGM- 600

  Fly   711 GNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIK 775
               :.|:||.||||||:|:||||:|||.:.:.||.:||.||||:|||||||:|..  :::.||||
Mouse   601 ---KVYIDPFTYEDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKLPGR--REVFVAIK 660

  Fly   776 TLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKF 840
            |||.|.:|:.|.|||:||||||||||||:|.|:||||:|.||||:||:|||.:||:|||:|||:|
Mouse   661 TLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQF 725

  Fly   841 QTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIEN--ASDAYTTR 903
            ..:||:.||||||:||.|||:||||||||||||:|||:.|:||::||||||.:|:  :...||:.
Mouse   726 TVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSS 790

  Fly   904 -GGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAP 967
             |||||:|||||||||:|||||||||||||:|:||||||||||||:.||||||.::|:.||||.|
Mouse   791 LGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPP 855

  Fly   968 MDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDGNHILDGQ-RGQN 1031
            ||||.||:|||||||.:.|..||.|:.||:|||.|.|...||..|..:|......:||.. ....
Mouse   856 MDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNAASLKVTASAPSGMSQPLLDRTVPDYT 920

  Fly  1032 IFISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKIL 1086
            .|.:...||:.|||.||...|..|...:...::::||:.|..:|:||.|||||||
Mouse   921 TFTTVGDWLDAIKMGRYKESFVGAGFASFDLVAQMTAEDLLRIGVTLAGHQKKIL 975

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 71/179 (40%)
FN3 387..476 CDD:238020 22/103 (21%)
FN3 536..623 CDD:238020 21/86 (24%)
EphA2_TM 644..736 CDD:291255 25/92 (27%)
PTKc_EphR 736..1002 CDD:270629 182/268 (68%)
Pkinase_Tyr 741..999 CDD:285015 177/260 (68%)
SAM_1 1033..1092 CDD:278937 23/54 (43%)
SAM 1039..1092 CDD:197735 22/48 (46%)
Ephb3XP_006521851.1 EphR_LBD_B3 31..203 CDD:198446 71/179 (40%)
fn3 333..431 CDD:365830 24/117 (21%)
FN3 <468..537 CDD:238020 19/71 (27%)
EphA2_TM 572..623 CDD:373140 21/79 (27%)
PTKc_EphR_B 623..891 CDD:173638 182/269 (68%)
SAM_superfamily 917..985 CDD:387673 23/59 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 398 1.000 Domainoid score I745
eggNOG 1 0.900 - - E2759_KOG0196
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 760 1.000 Inparanoid score I548
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45908
OrthoDB 1 1.010 - - D397694at33208
OrthoFinder 1 1.000 - - FOG0000086
OrthoInspector 1 1.000 - - otm44283
orthoMCL 1 0.900 - - OOG6_100189
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X82
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1211.740

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