Protein Alignment Eph and Ephb2

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: XP_006538597.1
• Gene: Ephb2 / 13844
• MGIID: 99611
• Length: 988
• Species: Mus musculus
• Alignment Length: 1057
• Identity: 445/1057 - (42%)
• Similarity: 609/1057 - (57%)
• Gaps: 126/1057 - (11%)

  Fly    79 LAHADQVVLLDTTREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINW-RSYVVCDVAYHNVNNW 142
            ||..::.::..||..|.|.|..:|      ..||.|.|..|  :.:|. |:|.||:|...:.|||
Mouse    16 LAAVEETLMDSTTATAELGWMVHP------PSGWEEVSGYD--ENMNTIRTYQVCNVFESSQNNW 72

  Fly   143 LWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYE--FDAATREPPPWQTDSYRL 205
            |.:.||.|..|:|:::|::|::||||..|....||||||:|.:||  ||.||:..|.|..:.:..
Mouse    73 LRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDLATKTFPNWMENPWVK 137

  Fly   206 IARIAAGEGRFNQNSDVD-------INTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCP 262
            :..|||.|. |:|   ||       |||||:|.. |::.|.|.||:|.|.|:|::||:|:|..||
Mouse   138 VDTIAADES-FSQ---VDLGGRVMKINTEVRSFGPVSRNGFYLAFQDYGGCMSLIAVRVFYRKCP 198

  Fly   263 AVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYL-CKGDGKWTILTGGCRCKAGYEPN 326
            .:.:|.|.|.||.:|.|.|.:....|:|:.|||..:.|..| |.|||:|.:..|.|.||||:|..
Mouse   199 RIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAV 263

  Fly   327 YTNKTCTECPLGTFKSPEVTK-CTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAP 390
            .....|..||.||||:.:..: ||.||.||..:..|:..|.|.:|:||...|...|||.:.|:||
Mouse   264 ENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGATNCVCRNGYYRADLDPLDMPCTTIPSAP 328

  Fly   391 TNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI----------KCNICSPNVVYN 445
             ...:..|::||.::.|:.|  .:|...|        |:||.|          .|..|..||.|.
Mouse   329 -QAVISSVNETSLMLEWTPP--RDSGGRE--------DLVYNIICKSCGSGRGACTRCGDNVQYA 382

  Fly   446 PSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPL 510
            |......|.:|.:::|...|.||.:|.|:|.|:..:.|....
Mouse   383 PRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPFSPQF----------------------- 424

  Fly   511 DLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELD 575
                     |.:..||.....|.|..:..::.|.....|.|.:|.|.:..:..||::::.|.||.
Mouse   425 ---------ASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKQELS 480

  Fly   576 AINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSV--QIR 638
            ..|.:|:.:......:.||.....|.||||.:|..|:|.||..:|.||:..  :.|..|:  ::.
Mouse   481 EYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTE--AEYQTSIKEKLP 543

  Fly   639 FIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHL 703
            .|.|:...|::||:..::..:...|.:..:..|.:.|:.|.   .|.|..:     ||.:|
Mouse   544 LIVGSSAAGLVFLIAVVVIAIVCNRRRGFERADSEYTDKLQ---HYTSGHM-----TPGMK---- 596

  Fly   704 NVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQ 768
                       .|:||.||||||:|:||||:|||.:.:.||.:||.||||:||.|.||:|..  :
Mouse   597 -----------IYIDPFTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGK--R 648

  Fly   769 DIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFL 833
            :|.|||||||.|.:||.|.|||:||||||||||||||:|:||||:|.|||||||:|||||||:||
Mouse   649 EIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFL 713

  Fly   834 RVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIE-NAS 897
            |.|||:|..:||:.||||||:||.||:|||||||||||||:|||:.|:||::||||||.:| :.|
Mouse   714 RQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTS 778

  Fly   898 D-AYTTR-GGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEK 960
            | .||:. |||||:||||||||.:|||||||||||||:|:||||||||||||:.:|||||.:||:
Mouse   779 DPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQ 843

  Fly   961 GYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDGNHILD 1025
            .||||.|||||.||:|||||||||.|.|||.|..||:|||.:.|.|.||....|........:||
Mouse   844 DYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGINLPLLD 908

  Fly  1026 GQRGQNI-----FISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKI 1085
                :.|     |.:.|.|||.|||.:|...|..|...:...:|::..:.:..:|:||.||||||
Mouse   909 ----RTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKI 969

  Fly  1086 LH-------QARQLDTI 1095
            |:       |..|:.::
Mouse   970 LNSIQVMRAQMNQIQSV 986

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	75/185 (41%)
		FN3	387..476	CDD:238020	28/98 (29%)
		FN3	536..623	CDD:238020	25/86 (29%)
		EphA2_TM	640..738	CDD:464211	30/97 (31%)
		PTKc_EphR	736..1002	CDD:270629	190/268 (71%)
		SAM_1	1029..1092	CDD:425739	24/74 (32%)
Ephb2	XP_006538597.1	EphR_LBD_B2	19..196	CDD:198445	75/188 (40%)
		fn3	326..421	CDD:394996	29/105 (28%)
		fn3	437..521	CDD:394996	24/83 (29%)
		EphA2_TM	545..619	CDD:464211	29/96 (30%)
		PTKc_EphR_B	618..886	CDD:173638	190/269 (71%)
		SAM_EPH-B2	912..982	CDD:188951	23/69 (33%)