DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eph and Epha6

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:NP_031964.2 Gene:Epha6 / 13840 MGIID:108034 Length:1130 Species:Mus musculus


Alignment Length:1087 Identity:414/1087 - (38%)
Similarity:581/1087 - (53%) Gaps:172/1087 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 ADQVVLLDTTR-EATLEWTRYPYGPQAQTPGWVEESFTDF---VKGINWRSYVVCDVAYHNVNNW 142
            ::||||||||. ...|.|..||..      ||  ::.|:.   .:.|:  :|.||:|...|.|||
Mouse   126 SNQVVLLDTTTVMGELGWKTYPLN------GW--DAITEMDEHNRPIH--TYQVCNVMEPNQNNW 180

  Fly   143 LWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAA--TREPPPWQTDSYRL 205
            |.:.:|.|.:|.::|:|::||:|||:..|....:|||||:|.:.|.|.:  |:..|    ..|..
Mouse   181 LRTNWISRDAAQKIYVEMKFTLRDCNSIPWVLGTCKETFNLYYIESDESHGTKFKP----SQYIK 241

  Fly   206 IARIAAGEGRFNQ----NSDVDINTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCPAVT 265
            |..|||.|. |.|    :..:.:|||::.:. :.:||.|.||:|.||||::::|:|:|..||...
Mouse   242 IDTIAADES-FTQMDLGDRILKLNTEIREVGPIERKGFYLAFQDIGACIALVSVRVFYKKCPFTV 305

  Fly   266 ENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNK 330
            .|.|.|.:|....:.:.:.:..|:||.:||..:||...|..||.|.:..|.|.|..|||.  ...
Mouse   306 RNLAMFPDTIPRVDSSSLVEVRGSCVKSAEERDTPKLYCGADGDWLVPLGRCICSTGYEE--IEG 368

  Fly   331 TCTECPLGTFKS-PEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLT 394
            :|..|..|.:|: ...|||:.|||:|:.....:..|.|..|::|...|...|.|..||:||.|:.
Mouse   369 SCHACRPGFYKAFAGNTKCSKCPPHSSTYVEATSVCHCEKGYFRAEKDPPSMACTRPPSAPRNVA 433

  Fly   395 LLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI----------KCNICSPNVVYNP-ST 448
             ..:::|:.|:.||.|       |:|..:   .|:.|.:          :|..|...:.:.| .|
Mouse   434 -FNINETALILEWSPP-------SDTGGR---KDLTYSVICKKCGLDTTQCEDCGGGLRFIPRHT 487

  Fly   449 DTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLN 513
            ...|.:.:.|..:..| .||.:|.|:|.||.:             ::|...|:            
Mouse   488 GLINNSVVVLDFVSHV-NYTFEIEAMNGVSEL-------------SISPKPFT------------ 526

  Fly   514 EVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAIN 578
                   .|..||:....|.:..:|....:.....|.|..|..|:..:..||::::.| |.:.:.
Mouse   527 -------AITVTTDHDAPSLIGMMRKDWASQNSLALSWQAPAFSNGAILDYEIKYYEK-EHEQLT 583

  Fly   579 KSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGA 643
            .|:..:|.....:.||...|.|.|.:|.:|..|:..||.....:|......:..:..||..||.|
Mouse   584 YSSTRSKAPSVIVTGLKPATTYIFHIRVRTATGYSGYSQKFEFETGDETSDMAAEQGQILVIATA 648

  Fly   644 IVTGVLFLVI---FIIAT---VYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLH 702
            .|.|...|||   |.:.|   .:::::|.:.  ::|...||                    :..|
Mouse   649 AVGGFTLLVILTLFFLITGRCQWYIKAKMKS--EEKRRTHL--------------------QNGH 691

  Fly   703 LNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFV 767
            |.     |...::|:||.|||||:.|:.|||:|||.:.|.||.:||.||||:||.||||.|..  
Mouse   692 LR-----FPGIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGK-- 749

  Fly   768 QDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTR------------------- 813
            ::|.|||||||.|..::.|.|||.||||||||||||:|.|:||||:                   
Mouse   750 REIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAG 814

  Fly   814 -----------------------SNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASG 855
                                   ..||||:.|||||||||:|||.:||.|..:||:.||||||||
Mouse   815 FLNGIQAPHPVTAGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASG 879

  Fly   856 MSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASD-AYTTRGGKIPVRWTAPEAIAF 919
            |.|||||.||||||||||:|||:.|:||::||||||.:|:..: ||||.|||||:|||||||||:
Mouse   880 MKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTTGGKIPIRWTAPEAIAY 944

  Fly   920 RKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQK 984
            |||:||||.||||:|:||||||||||||..||||||.|||:||||||||.||.:|:||||.||||
Mouse   945 RKFSSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLPAPMGCPPSLHQLMLHCWQK 1009

  Fly   985 QRTHRPTFASIVSTLDNLARQPQSLLTTRPS----PESDGNHILDGQRGQNIFISTDLWLEHIKM 1045
            :|.|||.|..|||.||.|.|.|.:|.|....    |||.|:     .....:|::...||:.|||
Mouse  1010 ERNHRPKFTDIVSFLDKLIRNPSALHTLVEDILVMPESPGD-----VPEYPLFVTVGDWLDSIKM 1069

  Fly  1046 SRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKILHQARQL 1092
            .:|..:|..|.......|||::...:..:|:.|:|||::|:...:.|
Mouse  1070 GQYKSNFMAAGFTTFDLISRMSIDDIRRIGVILIGHQRRIVSSIQTL 1116

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 69/185 (37%)
FN3 387..476 CDD:238020 24/99 (24%)
FN3 536..623 CDD:238020 21/86 (24%)
EphA2_TM 644..736 CDD:291255 26/97 (27%)
PTKc_EphR 736..1002 CDD:270629 187/308 (61%)
Pkinase_Tyr 741..999 CDD:285015 183/300 (61%)
SAM_1 1033..1092 CDD:278937 18/58 (31%)
SAM 1039..1092 CDD:197735 17/52 (33%)
Epha6NP_031964.2 EphR_LBD_A6 128..300 CDD:198452 70/186 (38%)
GCC2_GCC3 <370..406 CDD:285001 12/35 (34%)
fn3 427..521 CDD:278470 26/118 (22%)
FN3 549..628 CDD:238020 20/79 (25%)
EphA2_TM 648..720 CDD:291255 27/98 (28%)
PTKc_EphR_A 720..1028 CDD:270651 187/309 (61%)
Pkinase_Tyr 725..1024 CDD:285015 183/300 (61%)
SAM 1052..1119 CDD:197735 19/65 (29%)
SAM_EPH-A6 1055..1118 CDD:188946 19/62 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 121 1.000 Domainoid score I5665
eggNOG 1 0.900 - - E2759_KOG0196
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 760 1.000 Inparanoid score I548
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45908
OrthoDB 1 1.010 - - D397694at33208
OrthoFinder 1 1.000 - - FOG0000086
OrthoInspector 1 1.000 - - otm44283
orthoMCL 1 0.900 - - OOG6_100189
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X82
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.880

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