Protein Alignment Eph and Epha5

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: XP_006534832.1
• Gene: Epha5 / 13839
• MGIID: 99654
• Length: 1040
• Species: Mus musculus
• Alignment Length: 1087
• Identity: 434/1087 - (39%)
• Similarity: 606/1087 - (55%)
• Gaps: 158/1087 - (14%)

  Fly    65 LRTILLIIISIHFKLAH-ADQVVLLDT-TREATLEWTRYPYGPQAQTPGW-----VEESFTDFVK 122
            |.|.||:..::...||. :::|.|||: |....|.|..:|..      ||     |:|::...
Mouse    42 LWTCLLLCAALRTLLASPSNEVNLLDSRTVMGDLGWIAFPKN------GWEEIGEVDENYAPI-- 98

  Fly   123 GINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYE 187
                .:|.||.|...|.||||.:.:|....|:|::||::||:|||:..||...:|||||::.::|
Mouse    99 ----HTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFE 159

  Fly   188 FD----AATREPPPWQTDSYRLIARIAAGEGRFNQ----NSDVDINTEVKSIA-VNKKGVYFAFR 243
            .|    .:.:|      :.|..|..|||.|. |.:    :..:.:||||:.:. ::|||.|.||:
Mouse   160 SDDENGRSIKE------NQYIKIDTIAADES-FTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQ 217

  Fly   244 DQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDG 308
            |.||||::::|:|||..||:|..:.|.|.:|.||.:.:.:.:.:|:||:::...:.|...|..:|
Mouse   218 DVGACIALVSVRVYYKKCPSVVRHLAIFPDTITGADSSQLLEVSGSCVNHSVTDDPPKMHCSAEG 282

  Fly   309 KWTILTGGCRCKAGYEPNYTNKTCTECPLGTFK-SPEVTKCTPCPPNSNASKTGSPFCKCASGFY 372
            :|.:..|.|.||||||..  |.||..|..|.|| ||....|:.|||:|...:..|..|.|...::
Mouse   283 EWLVPIGKCMCKAGYEEK--NGTCQVCRPGFFKASPHSQTCSKCPPHSYTHEEASTSCVCEKDYF 345

  Fly   373 RHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI---K 434
            |..:|...|.|..||:||.| .:..|::||..:.|..||       :|..:   .|:.|.|   |
Mouse   346 RKDSDPPTMACTRPPSAPRN-AISNVNETSVFLEWIPPA-------DTGGR---KDVSYYIACKK 399

  Fly   435 CNI-------CSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSL 492
            ||.       |..:|.|.|.......|.:.:.:|...|.||.:|.|:|.||
Mouse   400 CNSHAGVCEECGGHVRYLPQQIGLKNTSVMMVDLLAHTNYTFEIEAVNGVS-------------- 450

  Fly   493 VAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQS 557
                              ||:........:..||.....|.|.|::...|......|.|.:|.:.
Mouse   451 ------------------DLSPGTRQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISLSWQEPDRP 497

  Fly   558 DFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQ 622
            :..:..||:::|.|.:  ..:.:.:.:|||.....||...:.|.||:|.:|..|:|.:|.....:
Mouse   498 NGIILEYEIKYFEKDQ--ETSYTIIKSKETSITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFE 560

  Fly   623 TLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFI---------------------------IATVY 660
            |.....:..:|..||..||.::..||:.|.:.|                           |....
Mouse   561 TTPVSVAASNDQSQIPIIAVSVTVGVILLAVMIGFLLSGSCCDCGCGRASSLCAVAHPSLIWRCG 625

  Fly   661 FMRSKHQDDLDKK---STNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTY 722
            :.::| ||..::|   ...|:.||                              ..|:|:|||||
Mouse   626 YSKAK-QDPEEEKMHFHNGHIKLP------------------------------GVRTYIDPHTY 659

  Fly   723 EDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARC 787
            ||||||:.|||:||:|:.||||.:||.||||:||.||||:|..  :::.|||||||.|.:||.|.
Mouse   660 EDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGK--RELPVAIKTLKVGYTEKQRR 722

  Fly   788 DFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGI 852
            |||.||||||||||||:|:|:||||:|.||||:|||||||||||||:.|||:|..:||:.|||||
Mouse   723 DFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGI 787

  Fly   853 ASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASD-AYTTRGGKIPVRWTAPEA 916
            |:||.|||||.||||||||||:|:|:.|:||::||||||.:|:..: ||||||||||:|||||||
Mouse   788 AAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEA 852

  Fly   917 IAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDC 981
            ||||||||:|||||||:|:|||:||||||||..:||||||::|:|||||:|||||.|||||||||
Mouse   853 IAFRKFTSSSDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDC 917

  Fly   982 WQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDGNHILD-GQRGQNIFISTDLWLEHIKM 1045
            |||.|..||.|..||:.||.|.|.|.||.|...:.......:.: |..|...:.|...|||.|||
Mouse   918 WQKDRNSRPKFDEIVNMLDKLIRNPSSLKTLVNASSRVSTLLAEHGSLGSGAYRSVGEWLEAIKM 982

  Fly  1046 SRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKILHQARQL 1092
            .||...|.|....:...::::|.:.|..:|:|||||||||:...:::
Mouse   983 GRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMSSLQEM 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	67/189 (35%)
		FN3	387..476	CDD:238020	28/98 (29%)
		FN3	536..623	CDD:238020	22/86 (26%)
		EphA2_TM	640..738	CDD:464211	32/127 (25%)
		PTKc_EphR	736..1002	CDD:270629	191/266 (72%)
		SAM_1	1029..1092	CDD:425739	24/62 (39%)
Epha5	XP_006534832.1	EphR_LBD	62..234	CDD:470656	67/190 (35%)
		FN3	<357..>600	CDD:442628	70/287 (24%)
		FN3	471..561	CDD:238020	24/91 (26%)
		EphA2_TM	578..675	CDD:464211	32/127 (25%)
		PTKc_EphR_A	673..939	CDD:270651	191/267 (72%)
		SAM_EPH-A5	968..1033	CDD:188945	23/62 (37%)