DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and Epha1

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_076069.2	Gene:	Epha1 / 13835	MGIID:	107381	Length:	977	Species:	Mus musculus

Alignment Length:	1078	Identity:	384/1078 - (35%)
Similarity:	555/1078 - (51%)	Gaps:	173/1078 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LRTILLIIISIHFKLAHADQVVLLDT-TREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRS 128
            |..:||::.:.....|.|::|.|:|| |.:..|.|...|  |:.   ||.|  ....:.|.....
Mouse     9 LALLLLLLCAPLPPGARAEEVTLMDTSTAQGELGWLLDP--PET---GWSE--VQQMLNGTPLYM 66

  Fly   129 YVVCDVAY-HNVNNWLWSPFIDRG-SANRLYIEIQFTIRDCSLFPGNA--LSCKETFSLLFYEFD 189
            |..|.:.. .:.::||.|.:|.|| .|:|:|:|:|||:|||..|||.|  |.|||||:|.:.|.|
Mouse    67 YQDCPIQEGGDTDHWLRSNWIYRGEEASRIYVELQFTVRDCKSFPGGAGPLGCKETFNLFYMESD 131

  Fly   190 ----AATREPPPWQTDSYRLIARIAAGEG---RFNQNSDVDINTEVKSIA-VNKKGVYFAFRDQG 246
                ...|.|      .::.:..:||.:.   |...:..|.:|.|..|:. :.::|:|.||.:.|
Mouse   132 QDVGIQLRRP------LFQKVTTVAADQSFTIRDLASGSVKLNVERCSLGHLTRRGLYLAFHNPG 190

  Fly   247 ACISVLAVKVYYITCPAVTENFAHFNET---PTGREITIIEKQNGTCVDNAE----PYETPTYLC 304
            :|:::::|:|:|..|.......|||.:|   |.|    ::|.. |||:.:|:    ...||...|
Mouse   191 SCVALVSVRVFYQRCAETVHGLAHFPDTLPGPGG----LVEVA-GTCLSHAQISLGSSGTPRMHC 250

  Fly   305 KGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFK-SPEVTKCTPCPPNSNASKTGSPFCKCA 368
            ..||:|.:..|.|:|:.|||.:..|..||.||.|.:: .....:|..||.:|.|...||..|.|.
Mouse   251 SPDGEWLVPVGQCQCEPGYEESSGNVGCTACPTGFYRVDMNTLRCLKCPQHSIAESEGSTICTCE 315

  Fly   369 SGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI 433
            :|.||.|.:|..:.|..||:||.||: .....|...:.|..|       .:|..:   .||.|.:
Mouse   316 NGHYRAPGEGPQVACTRPPSAPQNLS-FSTSGTQLSLRWEPP-------RDTGGR---HDIRYSV 369

  Fly   434 K-------------CNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKR 485
            :             |..|...|.::|:......:.:.:..|||...||..:.:.|.||.::
Mouse   370 ECLQCRGIAQDGGPCQPCGKGVHFSPAASGLTTSTVQVQGLEPYANYTFTVKSQNRVSGLD---- 430

  Fly   486 HSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFT-----TESVLLSTVFNLRILAITNK 545
             |:..|..::|..:....||..:.|.|.:.:..|.|:.:.     .....||  :.|.:|
Mouse   431 -SSSPSSASLSINMGHAESLSGLSLKLVKKEPRQLELTWAGSRPRNPGGNLS--YELHVL----- 487

  Fly   546 DADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNN 610
            :.|.||.:.|     ||       |:|.|            ||     |..:|.|..:||..|..
Mouse   488 NQDEEWHQMV-----LE-------PRVLL------------TK-----LQPDTTYIVRVRTLTPL 523

  Fly   611 GFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLF---LVIFIIATVYFMRSK-----HQ 667
            |.|.:|.....:|...|.         |.:.|..:..|:|   |.|.::..:|..||:     .|
Mouse   524 GPGPFSPDHEFRTSPPVS---------RSLTGGEIVAVIFGLLLGIALLIGIYVFRSRRGQRQRQ 579

  Fly   668 DDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREF 732
            ....:::||            |:..|      ||.|          :.|||...||||.|...:|
Mouse   580 QRQRERTTN------------VDRED------KLWL----------KPYVDLQAYEDPAQGALDF 616

  Fly   733 AREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDI-DVAIKTLKPGSSEKARCDFLTEASIM 796
            |:|:|..::.::.:||.||||:|.||.|::|.   ||. .|||||||..|.:....:||.||:||
Mouse   617 AQELDPAWLIVDTVIGEGEFGEVYRGALRLPS---QDCKTVAIKTLKDTSPDGYWWNFLREATIM 678

  Fly   797 GQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSD 861
            |||:||:::.|:||:|:..|:|||||:||||:||.||:..:.:....||:.||.||||||:.||.
Mouse   679 GQFNHPHILRLEGVITKRKPIMIITEFMENGALDAFLKEREDQLAPGQLVAMLLGIASGMNCLSG 743

  Fly   862 MNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSAS 926
            .|||||||||||:|||..|.||::||||:|.:::....|.|:|||||:|||||||||.|.||:||
Mouse   744 HNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTAS 808

  Fly   927 DVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPT 991
            ||||:|:|:|||:|:|::||...|||:|:||||.|||||.|:|||..||:||.:||...|..||.
Mouse   809 DVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPH 873

  Fly   992 FASIVSTLDNLARQPQSLLT--------TRPSPESDGNHILDGQRGQNIFISTDLWLEHIKMSRY 1048
            |..:.:.|:.|...|.||.|        |...|...|:   ||..    :.|...|||.|:|.||
Mouse   874 FLQLQAHLEQLLTDPHSLRTIANFDPRVTLRLPSLSGS---DGIP----YRSVSEWLESIRMKRY 931

  Fly  1049 CHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKIL 1086
            ..||:.|.|...:.:..|||:.|:.|||||.||||:||
Mouse   932 ILHFRSAGLDTMECVLELTAEDLTQMGITLPGHQKRIL 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	62/187 (33%)
		FN3	387..476	CDD:238020	21/101 (21%)
		FN3	536..623	CDD:238020	22/86 (26%)
		EphA2_TM	644..736	CDD:291255	25/99 (25%)
		PTKc_EphR	736..1002	CDD:270629	147/266 (55%)
		Pkinase_Tyr	741..999	CDD:285015	145/258 (56%)
		SAM_1	1033..1092	CDD:278937	27/54 (50%)
		SAM	1039..1092	CDD:197735	26/48 (54%)
Epha1	NP_076069.2	EphR_LBD_A1	28..204	CDD:198447	62/188 (33%)
		fn3	335..426	CDD:278470	21/101 (21%)
		FN3	454..536	CDD:238020	28/117 (24%)
		EphA2_TM	<597..620	CDD:291255	11/32 (34%)
		PKc_like	620..885	CDD:304357	147/267 (55%)
		Pkinase_Tyr	625..881	CDD:285015	145/258 (56%)
		SAM	912..977	CDD:197735	29/62 (47%)
		SAM_EPH-A1	913..975	CDD:188941	28/61 (46%)
		PDZ-binding. /evidence=ECO:0000255	975..977
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5665
eggNOG	1	0.900	-	-		E2759_KOG0196
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D397694at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100189
Panther	1	1.100	-	-	O	PTHR24416
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X82
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.910