Protein Alignment Eph and LOC116410852

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: XP_031757922.1
• Gene: LOC116410852 / 116410852
• XenbaseID: XB-GENE-29096463
• Length: 728
• Species: Xenopus tropicalis
• Alignment Length: 779
• Identity: 329/779 - (42%)
• Similarity: 451/779 - (57%)
• Gaps: 94/779 - (12%)

  Fly   348 CTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAK 412
            |..||.||..:..|:..|.|.:|:||..:|...|||.:.|:||.|: :..|::||.::.|:.|
 Frog    11 CLHCPINSRTTSEGATNCVCRTGYYRSDSDPMQMPCTTIPSAPQNV-ISSVNETSLMLEWAPP-- 72

  Fly   413 NESFSSETNSKIYHSDIVYKI----------KCNICSPNVVYNPSTDTFNETKITLTNLEPVTTY 467
            .:|...|        |:||.|          .|..|..||.:.|......|.::.:::|...|.|
 Frog    73 RDSGGRE--------DLVYNIICKSCGSGRGACTRCGDNVQFAPRQLGLTEPRVYISDLLAHTQY 129

  Fly   468 TVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLS 532
            |.::.|:|.|:..:.:..|.                                |.:..||.....|
 Frog   130 TFEVQAVNGVTDQSPYSPHF--------------------------------ASVNITTNQAAPS 162

  Fly   533 TVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLEN 597
            :|..:.:::.|.....|.|.:|.|.:..:..||:.::.| ||...|.|.:.:......:.||...
 Frog   163 SVSIMHLVSRTVDSITLSWSQPDQPNGVILDYELLYYEK-ELTEHNSSVVKSSTNTVLVPGLKAG 226

  Fly   598 TEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQ--IRFIAGAIVTGVLFLVIFIIATVY 660
            |.|.||||.:|..|:|.||..:|.||:..  :.|..|.|  :..|.|:...|::||:..::..:.
 Frog   227 TIYVFQVRARTVAGYGRYSGKMYFQTMTE--AEYQSSFQEKLPLIIGSSAAGLVFLIALVVIIIV 289

  Fly   661 FMR--------SKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYV 717
            ..|        |::.|.|...::.|....|........|:..||.:|               .|:
 Frog   290 CNRRRGFERADSEYTDKLQHYTSGHSTYRLPSPGLGARSLVVTPGMK---------------IYI 339

  Fly   718 DPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSS 782
            ||.||||||:|:||||:|||.:.:.||.:||.||||:||.|.||:|..  ::|.|||||||.|.:
 Frog   340 DPFTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGK--REIFVAIKTLKSGYT 402

  Fly   783 EKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIV 847
            ||.|.|||:||||||||||||||:|:||||:|:|||||||:|||||||:|||.|||:|..:||:.
 Frog   403 EKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSSPVMIITEFMENGSLDSFLRQNDGQFTVIQLVG 467

  Fly   848 MLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIE-NASD-AYTTR-GGKIPV 909
            ||||||:||.||:|||||||||||||:|||:.|:||::||||||.:| :.|| .||:. |||||:
 Frog   468 MLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPI 532

  Fly   910 RWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEAL 974
            ||||||||.:|||||||||||||:|:||||||||||||:.:|||||.:||:.||||.|||||.||
 Frog   533 RWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPNAL 597

  Fly   975 YQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDGNHILDGQ-RGQNIFISTDL 1038
            :|||||||||.|.|||.|..||:|||.:.|.|.:|....|........:||.. .....|.:.|.
 Frog   598 HQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNTLKAVAPLSSGVTLPLLDRTVPDYTSFSTVDE 662

  Fly  1039 WLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKILH-------QARQLDTI 1095
            ||:.|||.:|...|..|.......:|:::.:.:..:|:||.|||||||:       |..|:.::
 Frog   663 WLDAIKMGQYKESFASAGFSAFDVVSQMSMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQSV 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	26/98 (27%)
		FN3	536..623	CDD:238020	26/86 (30%)
		EphA2_TM	640..738	CDD:464211	31/105 (30%)
		PTKc_EphR	736..1002	CDD:270629	190/268 (71%)
		SAM_1	1029..1092	CDD:425739	22/69 (32%)
LOC116410852	XP_031757922.1	fn3	51..146	CDD:394996	27/105 (26%)
		fn3	162..245	CDD:394996	25/83 (30%)
		EphA2_TM	269..359	CDD:464211	30/104 (29%)
		PTKc_EphR_B	358..626	CDD:173638	190/269 (71%)
		SAM_EPH-B2	652..722	CDD:188951	22/69 (32%)