DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eph and si:ch73-40a2.1

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	XP_009301289.1	Gene:	si:ch73-40a2.1 / 101885322	ZFINID:	ZDB-GENE-160728-89	Length:	746	Species:	Danio rerio

Alignment Length:	968	Identity:	218/968 - (22%)
Similarity:	356/968 - (36%)	Gaps:	316/968 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 LLDTTREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCDVAYHNVNNWLWSPFIDRG 151
            :.|:::|:..:||..|      ...| ||:.....|......|..|:..:...:..|.:.:|.:.
Zfish    31 IFDSSKESRSKWTGSP------ARDW-EETEMQLGKPHAHPVYHACNPEFKKKSKKLLTKWIPKQ 88

  Fly   152 SANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAATREPPPWQTDSYRLIAR---IAAGE 213
            .|..|.:::.|...|            :....:|......:::|...|.....:..:   :|.|.
Zfish    89 DARELLLDLSFAQVD------------QQPLYIFVIKSNQSQKPYGPQKPVLAITVQHPFLANGY 141

  Fly   214 GRFNQNSDVDINTEVKSI---AVNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAHFNETP 275
            .|     |.|: :..|::   .:::...|..|...|.|:.:.:|:|:::.|||.|.....|.||.
Zfish   142 PR-----DEDL-SHAKALNLGNISENSFYLEFSYSGNCMFIASVQVFFLKCPAFTWKQMKFEETA 200

  Fly   276 TGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTF 340
            ..      ..:.|.|||.|....||...|:.:|.|....|.|.|.|.|:.  :..||.....|:.
Zfish   201 AR------GSRRGVCVDGAVEISTPLTECQSNGTWASPQGSCVCSAEYQS--SGDTCKANAPGSL 257

  Fly   341 KSPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAII 405
            .:        .||:.|..:...|                  |.::.......|.||.|  |..::
Zfish   258 LA--------TPPSINDPRPALP------------------PVHTGVVVGGVLLLLIV--TGVVL 294

  Fly   406 SWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQ 470
            .:....|...          |.|:
Zfish   295 LFVRHHKLRG----------HQDM----------------------------------------- 308

  Fly   471 IHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVF 535
              .:.|.|.:.:::|.         ::::.|.||.::.|    ||
Zfish   309 --ELVSESAVTQYRRQ---------TELLDSKTSSVSHP----EV-------------------- 338

  Fly   536 NLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEY 600
             .||:. .|:.|:.   ||.             ||..:::                    |.::|
Zfish   339 -CRIIG-QNQSAEC---KPC-------------FPTAQIE--------------------EASQY 365

  Fly   601 GFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSK 665
            .    |       :|..| ...||| :.|...||.|       ::.|:
Zfish   366 D----C-------AYEPM-RPHTLQ-LKSTMSDSDQ-------MLDGI----------------- 393

  Fly   666 HQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIR 730
                     .:||....|.            :|::..|.::..|
Zfish   394 ---------KDHLLCLRDV------------LVERTKLQLSQKL--------------------- 416

  Fly   731 EFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPG-SSEKARCDFLTEAS 794
                             |.||||.|..|...  |...|||.||:||.|.. .||:....||.||.
Zfish   417 -----------------GKGEFGAVYEGIFS--PKIGQDIRVAVKTSKDVIHSEEDLESFLKEAE 462

  Fly   795 IMGQFDHPNVIYLQGVVTRSNP------VMIITEYMENGSLDTFLRVNDGKFQTLQLIV----ML 849
            :|..|||.||:.|.||....:|      .::|..||::..|.:|||..  ::..:.:.|    :|
Zfish   463 MMKHFDHVNVVKLLGVALEWDPESSMVVPLVILPYMKHRDLHSFLRAT--RYDDVPMFVPHQSLL 525

  Fly   850 R---GIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENAS-DAYTTRGGKIPVR 910
            |   .||:||.|||...::||||||||.::...|...:||||||:.:.::: ..:.::..|:|||
Zfish   526 RFMMDIAAGMEYLSLQGFLHRDLAARNCMLGDDLRVCVADFGLSKMMYSSNYYRHKSQDVKLPVR 590

  Fly   911 WTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALY 975
            |.|.|:::...||:.|||||:||.:||:.|.|:.||...||.:::..:|||:|| :..|....||
Zfish   591 WMAIESVSDFIFTTKSDVWSFGVTMWEITSRGKVPYPGVSNYELLDYLEKGHRL-SQGDNDSKLY 654

  Fly   976 QLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPES--DGNHILDGQRGQN 1031
            :|||.||.:..:.||:|..:..:|       .:||:..|..|.  :.::|..|....|
Zfish   655 ELMLSCWHRDPSQRPSFGELHQSL-------SALLSELPPLEDRMESHYINLGLEAAN 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	32/178 (18%)
		FN3	387..476	CDD:238020	8/88 (9%)
		FN3	536..623	CDD:238020	13/86 (15%)
		EphA2_TM	644..736	CDD:291255	7/91 (8%)
		PTKc_EphR	736..1002	CDD:270629	105/280 (38%)
		Pkinase_Tyr	741..999	CDD:285015	104/272 (38%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
si:ch73-40a2.1	XP_009301289.1	EphR_LBD	42..185	CDD:295439	30/167 (18%)
		STYKc	410..678	CDD:214568	106/310 (34%)
		PTKc	415..678	CDD:270623	105/305 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D933071at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920