Protein Alignment Eph and si:ch73-40a2.1

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: XP_009301289.1
• Gene: si:ch73-40a2.1 / 101885322
• ZFINID: ZDB-GENE-160728-89
• Length: 746
• Species: Danio rerio
• Alignment Length: 968
• Identity: 218/968 - (22%)
• Similarity: 356/968 - (36%)
• Gaps: 316/968 - (32%)

  Fly    87 LLDTTREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCDVAYHNVNNWLWSPFIDRG 151
            :.|:::|:..:||..|      ...| ||:.....|......|..|:..:...:..|.:.:|.:.
Zfish    31 IFDSSKESRSKWTGSP------ARDW-EETEMQLGKPHAHPVYHACNPEFKKKSKKLLTKWIPKQ 88

  Fly   152 SANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAATREPPPWQTDSYRLIAR---IAAGE 213
            .|..|.:::.|...|            :....:|......:::|...|.....:..:   :|.|.
Zfish    89 DARELLLDLSFAQVD------------QQPLYIFVIKSNQSQKPYGPQKPVLAITVQHPFLANGY 141

  Fly   214 GRFNQNSDVDINTEVKSI---AVNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAHFNETP 275
            .|     |.|: :..|::   .:::...|..|...|.|:.:.:|:|:::.|||.|.....|.||.
Zfish   142 PR-----DEDL-SHAKALNLGNISENSFYLEFSYSGNCMFIASVQVFFLKCPAFTWKQMKFEETA 200

  Fly   276 TGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTF 340
            ..      ..:.|.|||.|....||...|:.:|.|....|.|.|.|.|:.  :..||.....|:.
Zfish   201 AR------GSRRGVCVDGAVEISTPLTECQSNGTWASPQGSCVCSAEYQS--SGDTCKANAPGSL 257

  Fly   341 KSPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAII 405
            .:        .||:.|..:...|                  |.::.......|.||.|  |..::
Zfish   258 LA--------TPPSINDPRPALP------------------PVHTGVVVGGVLLLLIV--TGVVL 294

  Fly   406 SWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQ 470
            .:....|...          |.|:
Zfish   295 LFVRHHKLRG----------HQDM----------------------------------------- 308

  Fly   471 IHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVF 535
              .:.|.|.:.:::|.         ::::.|.||.::.|    ||
Zfish   309 --ELVSESAVTQYRRQ---------TELLDSKTSSVSHP----EV-------------------- 338

  Fly   536 NLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEY 600
             .||:. .|:.|:.   ||.             ||..:::                    |.::|
Zfish   339 -CRIIG-QNQSAEC---KPC-------------FPTAQIE--------------------EASQY 365

  Fly   601 GFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSK 665
            .    |       :|..| ...||| :.|...||.|       ::.|:
Zfish   366 D----C-------AYEPM-RPHTLQ-LKSTMSDSDQ-------MLDGI----------------- 393

  Fly   666 HQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIR 730
                     .:||....|.            :|::..|.::..|
Zfish   394 ---------KDHLLCLRDV------------LVERTKLQLSQKL--------------------- 416

  Fly   731 EFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPG-SSEKARCDFLTEAS 794
                             |.||||.|..|...  |...|||.||:||.|.. .||:....||.||.
Zfish   417 -----------------GKGEFGAVYEGIFS--PKIGQDIRVAVKTSKDVIHSEEDLESFLKEAE 462

  Fly   795 IMGQFDHPNVIYLQGVVTRSNP------VMIITEYMENGSLDTFLRVNDGKFQTLQLIV----ML 849
            :|..|||.||:.|.||....:|      .::|..||::..|.:|||..  ::..:.:.|    :|
Zfish   463 MMKHFDHVNVVKLLGVALEWDPESSMVVPLVILPYMKHRDLHSFLRAT--RYDDVPMFVPHQSLL 525

  Fly   850 R---GIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENAS-DAYTTRGGKIPVR 910
            |   .||:||.|||...::||||||||.::...|...:||||||:.:.::: ..:.::..|:|||
Zfish   526 RFMMDIAAGMEYLSLQGFLHRDLAARNCMLGDDLRVCVADFGLSKMMYSSNYYRHKSQDVKLPVR 590

  Fly   911 WTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALY 975
            |.|.|:::...||:.|||||:||.:||:.|.|:.||...||.:::..:|||:|| :..|....||
Zfish   591 WMAIESVSDFIFTTKSDVWSFGVTMWEITSRGKVPYPGVSNYELLDYLEKGHRL-SQGDNDSKLY 654

  Fly   976 QLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPES--DGNHILDGQRGQN 1031
            :|||.||.:..:.||:|..:..:|       .:||:..|..|.  :.::|..|....|
Zfish   655 ELMLSCWHRDPSQRPSFGELHQSL-------SALLSELPPLEDRMESHYINLGLEAAN 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	32/178 (18%)
		FN3	387..476	CDD:238020	8/88 (9%)
		FN3	536..623	CDD:238020	13/86 (15%)
		EphA2_TM	640..738	CDD:464211	7/97 (7%)
		PTKc_EphR	736..1002	CDD:270629	105/280 (38%)
		SAM_1	1029..1092	CDD:425739	1/3 (33%)
si:ch73-40a2.1	XP_009301289.1	EphR_LBD	42..185	CDD:470656	30/167 (18%)
		PTKc	415..678	CDD:270623	105/305 (34%)